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CURRENT DIABETES REVIEWS
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BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573399820666230531161858
关键词
Type 1 diabetes mellitus; Advanced hybrid closed-loop; Sensor-augmented pump; Quality of life; Glycaemic outcomes; Diabetes distress
This study compared the Advanced Hybrid Closed-Loop (AHCL) system with the Sensor-Augmented Pump (SAP) with Predictive Low Glucose Management (PLGM) system in terms of glycaemic outcomes, general and diabetes-related Quality of Life (QoL), and diabetes distress. The findings demonstrated that the AHCL system had significant advantages over the SAP + PLGM system in terms of mean glucose levels, time above range, QoL, and diabetes distress. Linear regression models also revealed the association between time in range and these aspects.
Background Type 1 diabetes mellitus (T1D) is a chronic disease that requires exogenous insulin administration and intensive management to prevent any complications. Recent innovations in T1D management technologies include the Advanced Hybrid Closed-Loop delivery system (AHCL). The pioneer AHCL system provides automated basal and automated bolus corrections when neededObjectives This study aimed to compare the Advanced Hybrid Closed-Loop (AHCL) system and the Sensor-Augmented Pump (SAP) with Predictive Low Glucose Management (PLGM) system, in relation to glycaemic outcomes, general and diabetes-related Quality of Life (QoL), and diabetes distress.Methods General and diabetes-related QoL were assessed with the Diabetes Quality of Life Brief Clinical Inventory (DQOL-BCI) and the World Health Organization Quality of Life-BREF (WHOQOL-BREF), respectively. Diabetes distress was assessed with the Diabetes Distress Scale for Type 1 diabetes (T1-DDS).Results Eighty-nine T1D adults participated in the study, mostly females (65.2%), with a mean age of 39.8 (& PLUSMN; 11.5 years). They had on average 23 years of diabetes (& PLUSMN; 10.7) and they were on continuous subcutaneous insulin infusion therapy. Significant differences favoring the AHCL over the SAP + PLGM system were demonstrated by lower mean glucose levels, less time above range, lower scores on DQOL-BCI, T1-DDS, and higher scores on WHOQOL-BREF. Finally, the linear regression models revealed the association of time in range in most of the above aspects.Conclusion This study highlighted the advantages of the AHCL system over the SAP + PLGM system in the real-world setting in relation to general and diabetes-related QoL, diabetes distress, and glycaemic outcomes.
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