期刊
MAGNETIC RESONANCE IN MEDICINE
卷 77, 期 2, 页码 603-612出版社
WILEY
DOI: 10.1002/mrm.26143
关键词
restricted diffusion imaging (RDI); apparent diffusion coefficient (ADC); restricted diffusion; ischemia-reperfusion injury; immune cell infiltration
资金
- NIH [P41EB-001977, R01HL-081349]
PurposeDiffusion MRI provides a noninvasive way to assess tissue microstructure. Based on diffusion MRI, we propose a model-free method called restricted diffusion imaging (RDI) to quantify restricted diffusion and correlate it with cellularity. Theory and MethodsAn analytical relation between q-space signals and the density of restricted spins was derived to quantify restricted diffusion. A phantom study was conducted to investigate the performance of RDI, and RDI was applied to an animal study to assess immune cell infiltration in myocardial tissues with ischemia-reperfusion injury. ResultsOur phantom study showed a correlation coefficient of 0.998 between cell density and the restricted diffusion quantified by RDI. The animal study also showed that the high-value regions in RDI matched well with the macrophage infiltration areas in the H&E stained slides. In comparison with diffusion tensor imaging (DTI), RDI exhibited its outperformance to detect macrophage infiltration and delineate inflammatory myocardium. ConclusionRDI can be used to reveal cell density and detect immune cell infiltration. RDI exhibits better specificity than the diffusivity measurement derived from DTI. Magn Reson Med 77:603-612, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine
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