期刊
MAGNETIC RESONANCE IN MEDICINE
卷 78, 期 2, 页码 702-712出版社
WILEY
DOI: 10.1002/mrm.26394
关键词
iron oxide nanoparticle; biodistribution; primary clearance organs; SWIFT; hyperthermia
资金
- NIH [P41 EB015894]
- WM KECK Foundation
- NSF/CBET [1066343, 1336659]
- MN Futures Grant (UMN)
- NSF Graduate Research Fellowship [00006595]
- University of Minnesota IEM Cancer Animal Core Lab
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1066343] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1336659] Funding Source: National Science Foundation
PurposeTo use contrast based on longitudinal relaxation times (T-1) or rates (R-1) to quantify the biodistribution of iron oxide nanoparticles (IONPs), which are of interest for hyperthermia therapy, cell targeting, and drug delivery, within primary clearance organs. MethodsMesoporous silica-coated IONPs (msIONPs) were intravenously injected into 15 naive mice. Imaging and mapping of the longitudinal relaxation rate constant at 24h or 1 week postinjection were performed with an echoless pulse sequence (SWIFT). Alternating magnetic field heating measurements were also performed on ex vivo tissues. ResultsSignal enhancement from positive T-1 contrast caused by IONPs was observed and quantified in vivo in liver, spleen, and kidney at concentrations up to 3.2mg Fe/(g tissue wt.) (61mM Fe). In most cases, each organ had a linear correlation between the R-1 and the tissue iron concentration despite variations in intra-organ distribution, degradation, and IONP surface charge. Linear correlation between R-1 and volumetric SAR in hyperthermia therapy was observed. ConclusionThe linear dependence between R-1 and tissue iron concentration in major organs allows quantitative monitoring of IONP biodistribution in a dosage range relevant to magnetic hyperthermia applications, which falls into the concentration gap between CT and conventional MRI techniques. Magn Reson Med 78:702-712, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine
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