期刊
MAGNETIC RESONANCE IN MEDICINE
卷 77, 期 3, 页码 1104-1114出版社
WILEY
DOI: 10.1002/mrm.26195
关键词
diffusion MRI; filter exchange imaging; cell membrane permeability; study design
资金
- Swedish Cancer Society [CAN 2012/597, CAN 2013/321]
- Swedish Research Council [K2011-52X-21737-01-3]
- Swedish Brain Foundation [FO2014-0133]
- Swedish Foundation for Strategic Research [AM13-0090]
Purpose: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations. Methods: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance was investigated by test-retest acquisitions in six brain regions in 18 healthy volunteers. Preoperative FEXI data and postoperative microphotos were obtained in six meningiomas and five astrocytomas. Results: Protocol optimization reduced the coefficient of variation of AXR by approximately 40%. Test-retest AXR values were heterogeneous across normal brain regions, from 0.3 +/- 0.2 s(-1) in the corpus callosum to 1.8 +/- 0.3 s-1 in the frontal white matter. According to analysis of statistical power, in all brain regions except one, group differences of 0.3-0.5 s-1 in the AXR can be inferred using 5 to 10 subjects per group. An AXR difference of this magnitude was observed between meningiomas (0.6 +/- 0.1 s(-1)) and astrocytomas (1.0 +/- 0.3 s(-1)). Conclusions: With the optimized protocol, FEXI has the ability to infer relevant differences in the AXR between two populations for small group sizes. (C) 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc.
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