期刊
MAGNETIC RESONANCE IN MEDICINE
卷 78, 期 2, 页码 645-655出版社
WILEY
DOI: 10.1002/mrm.26459
关键词
CEST; APT; NOE; MT; LUT; z-spectra
资金
- Initial Training Network, HiMR
- FP7 Marie Curie Actions of the European Commission [FP7-PEOPLE-2012-ITN-316716]
- Medical Research Council
- MRC Doctoral Training Grant [MR/K501086/1]
- MRC UK MEG [MR/K005464/1]
- MRC [MR/K005464/1, MC_PC_13072, MR/N008537/1, MC_PC_15033, MC_PC_14102] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [1229960] Funding Source: researchfish
- Medical Research Council [MC_PC_14102, MC_PC_15033, MR/N008537/1, MC_PC_13072, 1371672] Funding Source: researchfish
PurposeTo develop a method that fits a multipool model to z-spectra acquired from non-steady state sequences, taking into account the effects of variations in T1 or B1 amplitude and the results estimating the parameters for a four-pool model to describe the z-spectrum from the healthy brain. MethodsWe compared measured spectra with a look-up table (LUT) of possible spectra and investigated the potential advantages of simultaneously considering spectra acquired at different saturation powers (coupled spectra) to provide sensitivity to a range of different physicochemical phenomena. ResultsThe LUT method provided reproducible results in healthy controls. The average values of the macromolecular pool sizes measured in white matter (WM) and gray matter (GM) of 10 healthy volunteers were 8.9%0.3% (intersubject standard deviation) and 4.4%+/- 0.4%, respectively, whereas the average nuclear Overhauser effect pool sizes in WM and GM were 5%+/- 0.1% and 3%+/- 0.1%, respectively, and average amide proton transfer pool sizes in WM and GM were 0.21%+/- 0.03% and 0.20%+/- 0.02%, respectively. ConclusionsThe proposed method demonstrated increased robustness when compared with existing methods (such as Lorentzian fitting and asymmetry analysis) while yielding fully quantitative results. The method can be adjusted to measure other parameters relevant to the z-spectrum. Magn Reson Med 78:645-655, 2017. (c) 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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