期刊
MAGNETIC RESONANCE IN MEDICINE
卷 78, 期 1, 页码 69-78出版社
WILEY
DOI: 10.1002/mrm.26336
关键词
diffusion tensor imaging; articular cartilage; cartilage mechanical injury; biomechanics; histology analysis
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institute of Health (NIH) [R21AR066897, RO1AR067789]
PurposeWe establish a mechanical injury model for articular cartilage to assess the sensitivity of diffusion tensor imaging (DTI) in detecting cartilage damage early in time. Mechanical injury provides a more realistic model of cartilage degradation compared with commonly used enzymatic degradation. MethodsNine cartilage-on-bone samples were obtained from patients undergoing knee replacement. The 3 Tesla DTI (0.18x0.18x1mm(3)) was performed before, 1 week, and 2 weeks after (zero, mild, and severe) injury, with a clinical radial spin-echo DTI (RAISED) sequence used in our hospital. We performed stress-relaxation tests and used a quasilinear-viscoelastic (QLV) model to characterize cartilage mechanical properties. Serial histology sections were dyed with Safranin-O and given an OARSI grade. We then correlated the changes in DTI parameters with the changes in QLV-parameters and OARSI grades. ResultsAfter severe injury the mean diffusivity increased after 1 and 2 weeks, whereas the fractional anisotropy decreased after 2 weeks (P<0.05). The QLV-parameters and OARSI grades of the severe injury group differed from the baseline with statistical significance. The changes in mean diffusivity across all the samples correlated with the changes in the OARSI grade (r=0.72) and QLV-parameters (r=-0.75). ConclusionDTI is sensitive in tracking early changes after mechanical injury, and its changes correlate with changes in biomechanics and histology. Magn Reson Med 78:69-78, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据