期刊
MAGNETIC RESONANCE IN MEDICINE
卷 77, 期 3, 页码 1276-1283出版社
WILEY
DOI: 10.1002/mrm.26214
关键词
osteochondritis dissecans; osteochondrosis; epiphyseal cartilage; chondronecrosis; vascular canal abnormality; cartilage canals; quantitative susceptibility mapping; high-field MRI; OCD; QSM
资金
- NIH/NIAMS [R21AR065385]
- NIH [T32OD10993, P41EB015894]
- NIH/NCRR [K18RR033297]
- WM KECK Foundation
- Comparative Medicine Signature Program at the University of Minnesota
- Academy of Finland [285909]
Purpose: To use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals in the distal femur of juvenile goats after their surgical transection. Methods: Chondronecrosis was surgically induced in the right medial femoral condyles of four 4-day-old goats. Both the operated and control knees were harvested at 2, 3, 5, and 10 weeks after the surgeries. Ex vivo MRI scans were conducted at 9.4 Tesla using TRAFF (relaxation time along a fictitious field)-weighted fast spin echo imaging and QSM to detect areas of chondronecrosis and investigate cartilage canal abnormalities. Histological sections from these same areas stained with hematoxylin and eosin and safranin O were evaluated to assess the affected tissues. Results: Both the histological sections and the TRAFF-weighted images of the femoral condyles demonstrated focal areas of chondronecrosis, evidenced by pyknotic chondrocyte nuclei, loss of matrix staining, and altered MR image contrast. At increasing time points after surgery, progressive changes and eventual disappearance of abnormal cartilage canals were observed in areas of chondronecrosis by using QSM. Conclusion: Abnormal cartilage canals were directly visualized in areas of surgically induced chondronecrosis. Quantitative susceptibility mapping enabled investigation of the vascular changes accompanying chondronecrosis in juvenile goats. (C) 2016 International Society for Magnetic Resonance inMedicine
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