期刊
MAGNETIC RESONANCE IMAGING
卷 34, 期 8, 页码 1220-1225出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2016.05.013
关键词
Intravoxel incoherent motion; DWI; Liver function; Child-Pugh class
Purpose: To explore the usefulness of intravoxel incoherent motion (IVIM) to evaluate the hepatic functional reserve as expressed by the model for Child-Pugh class. Materials and methods: IVIM diffusion-weighted imaging (DWI) using 10 different b values were performed on a Philips 3.0 T MR scanner in 70 patients with liver cirrhosis and 60 healthy volunteers as the control group. Patients with liver cirrhosis were subdivided into three groups: Child-Pugh class A: 29 cases; Child-Pugh class B: 19 cases; Child-Pugh class C: 22 cases. Pure molecular diffusion (D), pseudo-diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) values were calculated, and used to determine liver function, as indicated by the Child-Pugh class. Results: The ICC values of D, D*,f and ADC between two radiologists were 0.997, 0.986, 0.985 and 0.995, respectively. D*,f and ADC values of liver cirrhosis group were significantly lower than control group (P < 0.001, P = 0.016, P = 0.042, respectively). D*, f and ADC values significantly decreased with increasing Child-Pugh scores (p < 0.05). Child-Pugh scores were inversely correlated with DC and f values (r = -0.423, r = 0.620, respectively). The areas under the curve (AUCs) of D* and f for evaluating liver function were 0.67-0.90 and 0.78-0.89, respectively. Conclusion: IVIM DWI may be a useful image-based method for assessing liver function. (C) 2016 Elsevier Inc. All rights reserved.
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