期刊
MAGNETIC RESONANCE IMAGING
卷 34, 期 5, 页码 632-637出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2015.12.034
关键词
Three-dimensional magnetic resonance spectroscopic imaging; Knee; Osteoarthritis; Anterior cruciate ligament tear; Bone marrow; Bone marrow edema-like lesions
资金
- NIH [K25 AR053633, R01 AR46905]
Purpose: To quantitatively evaluate longitudinal changes in water and lipid in knee bone marrow with and without bone marrow edema-like lesions (BMELs) in subjects with acutely ruptured anterior cruciate ligaments (ACLs) or osteoarthritis (OA) using three-dimensional magnetic resonance spectroscopic imaging (3D MRSI). Material and methods: Ten ACL and 10 OA subjects who presented with BMEL and seven BMEL-free controls were scanned at 3 T. All ACL and OA subjects had one-year follow-up scans. 3D MRSI was acquired in BMEL and adjacent bone marrow, and water content (WC) and unsaturated lipid index (UI) were calculated in each region of interest. Results: At baseline, ACL BMEL WC was significantly higher than ACL non-BMEL, OA BMEL, and control WC; ACL non-BMEL WC, ACL BMEL UI, and OA BMEL WC were significantly higher than control. ACL BMEL WC decreased significantly one year post-reconstruction; UI decreased non-significantly (p = 0.09). No significant changes in OA BMEL or ACL and OA non-BMEL WC and UI were observed. Conclusion: 3D MRSI is a powerful method of quantitatively assessing the biochemical composition of bone marrow in OA and ACL-injured knees, which may serve as imaging markers to improve comprehension of primary and secondary OA pathology. (C) 2016 Elsevier Inc. All rights reserved.
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