4.5 Article

Clinical utility of resected pancreatic volume ratio calculation for predicting postoperative new-onset diabetes mellitus after distal pancreatectomy-a propensity-matched analysis

期刊

HELIYON
卷 9, 期 5, 页码 -

出版社

CELL PRESS
DOI: 10.1016/j.heliyon.2023.e15998

关键词

Distal pancreatectomy; New-onset diabetes mellitus; Operation-related risk factors; Resected pancreatic volume ratio; Propensity-matched analysis

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This study aimed to investigate the correlation between surgery-related factors and the incidence of new-onset diabetes mellitus (NODM) after distal pancreatectomy. The results showed that there was no significant correlation between NODM and operative blood loss, spleen preservation, surgical method, postoperative ALB and HB, and postoperative pathology. However, there was a significant correlation between NODM and postoperative pancreatic volume or resected pancreatic volume ratio. Resected pancreatic volume ratio was identified as a predictive risk factor for NODM.
Background:Limited literature is available on new-onset diabetes mellitus (NODM) after distal pancreatectomy. This study aimed to investigate the correlation between surgery-related factors and the incidence of NODM after distal pancreatectomy. Methods:Patients were divided into the NODM-positive or NODM-negative group according to the diagnosis of NODM. After propensity score matching, the correlation between operation-related factors and the incidence of NODM was analyzed. The diagnostic threshold for predicting NODM was determined using the receiver operating characteristic (ROC) curve and the Youden index. Results:No significant correlation was observed between the NODM incidence after distal pancreatectomy and operative blood loss, spleen preservation, surgical method (open or laparoscopy), postoperative ALB and HB (first day after surgery), and postoperative pathology. However, a significant correlation was found between the NODM incidence and the postoperative pancreatic volume or the resected pancreatic volume ratio. Resected pancreatic volume ratio was identified as a predictive risk factor for NODM. Youden index of the ROC curve was 0.548, with a cut off value of 32.05% for resected pancreatic volume ratio. The sensitivity and specificity of the cut off values were 0.952 and 0.595, respectively. Conclusions:This study demonstrated that the volume ratio of pancreatic resection is a risk factor for the incidence of NODM after distal pancreatectomy. This can be used to predict the incidence of NODM and may have further clinical applications.

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