HIF1A overexpression predicts the high lymph node metastasis risk and indicates a poor prognosis in papillary thyroid cancer

Article Endocrinology & Metabolism

Lymph node metastasis of papillary thyroid carcinoma in the context of Hashimoto's thyroiditis

Lirong Wang et al.

Summary: This study, using stringent diagnostic criteria for HT, found that HT may reduce the risk of lymph node metastasis in PTC. Age and tumor size were identified as independent risk factors for central lymph node metastasis in HT PTCs.

BMC ENDOCRINE DISORDERS (2022)

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Review Cell Biology

Mast Cell-Tumor Interactions: Molecular Mechanisms of Recruitment, Intratumoral Communication and Potential Therapeutic Targets for Tumor Growth

Deisy Segura-Villalobos et al.

Summary: This article reviews the recent evidence regarding the complex relationship between mast cells (MCs) and tumor cells, discussing the multifaceted role of MCs in tumor growth, the signaling pathways that regulate MC function and migration inside tumors, the possible phenotypic changes of MCs triggered by prevalent conditions in the tumor microenvironment, and the potential role of MCs in tumor fibrosis and metastasis. The article also discusses novel literature on molecular mechanisms related to phenotypic changes of MCs in the tumor microenvironment and therapeutic strategies targeting MC activation to limit tumor growth.

CELLS (2022)

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Article Surgery

Identification of the Ferroptosis-Related Long Non-Coding RNAs Signature to Improve the Prognosis Prediction in Papillary Renal Cell Carcinoma

Xinfang Tang et al.

Summary: A prognostic signature based on long non-coding RNAs associated with ferroptosis was established for papillary renal cell carcinoma (pRCC). High-risk scores were correlated with poor prognosis and the signature showed high predictive value. Pathway analysis revealed associations with immune and tumor-related pathways, as well as significant differences in T cell functions.

FRONTIERS IN SURGERY (2022)

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Article Medicine, General & Internal

Annexin A10 is a novel prognostic biomarker of papillary thyroid cancer

Xiaoyun Liu et al.

Summary: The study showed that ANXA10 was significantly upregulated in papillary thyroid cancer (PTC) and was associated with tumor size, differentiation, and overall survival rates. ANXA10 may serve as an independent prognostic biomarker for PTC, suggesting it could be a promising target for individualized treatment.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

CXCL10 is a potential biomarker and associated with immune infiltration in human papillary thyroid cancer

Xiao-Jing Qin et al.

Summary: Recent studies have shown that immune, stromal, and ESTIMATE scores are associated with clinicopathological variables in patients with papillary thyroid cancer, but not survival outcomes. The cytokine CXCL10 may serve as a core gene in the tumor immune microenvironment of papillary thyroid cancer and could be a potential target for precision therapy.

BIOSCIENCE REPORTS (2021)

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Article Cell Biology

A new risk factor indicator for papillary thyroid cancer based on immune infiltration

Zhou Yang et al.

Summary: The study comprehensively investigated immune infiltration in thyroid cancer using various algorithms to analyze data from TCGA and GEO databases. The presence of CD8(+) T cell infiltration was associated with improved survival in thyroid cancer patients. Immune checkpoint overexpression, the role of stromal cells, and the impact of BRAF(V600E) mutation on immune components in the tumor microenvironment were also highlighted. A risk score model was developed to predict thyroid cancer prognosis.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

Fang Zheng et al.

Summary: The study demonstrates a crucial positive feed-forward loop between HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha, which is essential for metabolic reprogramming and tumourigenesis mediated by HIF1alpha.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

HIF-1α is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer

Yana Zhang et al.

Summary: The activation and tumour-promotion function of CAFs in lung cancer are highly dependent on the increased expression of HIF-1 alpha. Targeting HIF-1 alpha expression on CAFs may be a promising strategy for lung cancer therapy as it significantly attenuates CAFs activation and inhibits tumour growth.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Immunology

Development and Validation of a Robust Immune-Related Prognostic Signature for Gastric Cancer

Junyu Huo et al.

Summary: This study constructed and validated a robust prognostic signature for gastric cancer (GC), which showed high predictive accuracy for overall survival (OS) and served as an independent indicator of prognosis for GC patients. Clinical correlation analysis suggested that different types of GC patients may have diverse risk scores, with the risk score increasing with the progression of clinicopathological stage.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Article Oncology

The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer

Jing-Zi Wang et al.

Summary: This study demonstrated that ALYREF stabilizes PKM2 mRNA and binds to its m5C sites in bladder cancer, promoting cell proliferation. High expressions of PKM2 and ALYREF predict poor prognosis in bladder cancer patients. Additionally, HIF-1alpha indirectly upregulates PKM2 expression by activating ALYREF, suggesting a promising therapeutic target for bladder cancer.

CANCER COMMUNICATIONS (2021)

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Article Oncology

Hypoxia-inducible factor-1α expression and breast cancer recurrence in a Danish population-based case control study

Lindsay J. Collin et al.

Summary: The study found that HIF-1α expression is not directly associated with overall breast cancer recurrence, but may be related to early recurrence in patients with ER-negative breast cancer.

BREAST CANCER RESEARCH (2021)

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Article Oncology

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer

Tao Ran et al.

Summary: This study investigated the association of LAMB1 expression with clinicopathological characteristics and prognosis in gastric cancer. The high expression of LAMB1 was found to be related to poor prognosis in patients with gastric cancer, potentially due to microenvironmental changes in tumors. GO/KEGG analysis revealed enrichment of LAMB1-related genes in signaling pathways and interactions associated with tumor progression.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

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Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Biochemistry & Molecular Biology

The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein

Raffaela Mariarosaria Mariniello et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Medicine, General & Internal

Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment

Naykky Singh Ospina et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Pharmacology & Pharmacy

Ginsenoside 20(S)-Rg3 upregulates HIF-1α-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells

Jiaojiao Lu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

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Article Oncology

Hypoxia Activates SOX5/Wnt/β-Catenin Signaling by Suppressing MiR-338-3p in Gastric Cancer

Jing-jing Zheng et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

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Article Genetics & Heredity

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

Flora Cimmino et al.

BMC MEDICAL GENETICS (2019)

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Article Genetics & Heredity

Tumor-Infiltrating Leukocyte Composition and Prognostic Power in Hepatitis B- and Hepatitis C-Related Hepatocellular Carcinomas

Yi-Wen Hsiao et al.

GENES (2019)

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Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

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Article Endocrinology & Metabolism

β-TrCP upregulates HIF-1 in prostate cancer cells

Maya Cohen et al.

PROSTATE (2019)

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Review Oncology

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

Katie L. Owen et al.

CANCERS (2019)

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Review Endocrinology & Metabolism

The roles and role-players in thyroid cancer angiogenesis

Sadegh Rajabi et al.

ENDOCRINE JOURNAL (2019)

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Review Otorhinolaryngology

Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta-analysis

Huy Gia Vuong et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2018)

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Review Cell Biology

Toll like receptor signaling pathway as a potential therapeutic target in colorectal cancer

Reyhaneh Moradi-Marjaneh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Oncology

Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1 /FAK signalling in breast cancer

Jie Shen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Oncology

Model of lymph node metastasis posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma

Yi Luo et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Focal adhesions: a personal perspective on a half century of progress

Keith Burridge

FEBS JOURNAL (2017)

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Review Biology

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

Yanqing Huang et al.

SCIENCE CHINA-LIFE SCIENCES (2017)

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Review Immunology

Mechanisms and consequences of Jak-STAT signaling in the immune system

Alejandro V. Villarino et al.

NATURE IMMUNOLOGY (2017)

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Article Oncology

Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma

Yan-Mei Liu et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2016)

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Review Pharmacology & Pharmacy

The extracellular matrix in breast cancer

Jacob Insua-Rodriguez et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Multidisciplinary Sciences

T cell exclusion, immune privilege, and the tumor microenvironment

Johanna A. Joyce et al.

SCIENCE (2015)

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Article Oncology

Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells

Eva Slabakova et al.

ONCOTARGET (2015)

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Article Multidisciplinary Sciences

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

Joana T. de Oliveira et al.

PLOS ONE (2015)

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Review Immunology

HIF Transcription Factors, Inflammation, and Immunity

Asis Palazon et al.

IMMUNITY (2014)

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Article Oncology

USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells

Zhen Ning et al.

ONCOLOGY REPORTS (2014)

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Article Biotechnology & Applied Microbiology

TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator

Ya-Ping Tsai et al.

GENOME BIOLOGY (2014)

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Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

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Article Pathology

Expression of hypoxia-inducible factor 1 alpha in papillary thyroid carcinoma is associated with desmoplastic stromal reaction and lymph node metastasis

Oskar Koperek et al.

VIRCHOWS ARCHIV (2013)

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HIF1A overexpression predicts the high lymph node metastasis risk and indicates a poor prognosis in papillary thyroid cancer

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