期刊
MACROMOLECULAR MATERIALS AND ENGINEERING
卷 301, 期 8, 页码 922-934出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.201600116
关键词
antibacterial; constructs; fibers; gyration; melt; nonwoven; polymer; pressure; tissue engineering
资金
- EPSRC [EP/L023059/1]
- Engineering and Physical Sciences Research Council [EP/L023059/1, EP/E045839/1] Funding Source: researchfish
- EPSRC [EP/E045839/1, EP/L023059/1] Funding Source: UKRI
A pressurized melt gyration process has been used for the first time to generate poly(e-caprolactone) (PCL) fibers. Gyration speed, working pressure, and melt temperature are varied and these parameters influence the fiber diameter and the temperature enabled changing the surface morphology of the fibers. Two types of nonwoven PCL fiber constructs are prepared. First, Ag-doped PCL is studied for antibacterial activity using Gram-negative Escherichia coli and Pseudomonas aeruginosa microorganisms. The melt temperature used to make these constructs significantly influences antibacterial activity. Neat PCL nonwoven scaffolds are also prepared and their potential for application in muscular tissue engineering is studied with myoblast cells. Results show significant cell attachment, growth, and proliferation of cells on the scaffolds.
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