期刊
MACROMOLECULAR MATERIALS AND ENGINEERING
卷 301, 期 11, 页码 1374-1382出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.201600222
关键词
biocompatibility; hydrogels; mechanical properties; poly(ethylene glycol); thermally induced CuAAC
资金
- National Natural Science Foundation of China [21274020, 21074022, 21504072, 21304019]
- Key Laboratory of Environmental Medicine Engineering of Ministry of Education (Southeast University)
- National 973 Project Foundation of China [2010CB944804]
- Fundamental Research Funds for the Central Universities
Poly(ethylene glycol) (PEG)-based hydrogels have attracted increasing attention in recent years due to their good biocompatibility and low cost. However, the PEG-based hydrogels prepared by traditional methods exhibit a poor machinability due to their disordered network structure. Herein, the preparation of well-defined PEG-based hydrogel via a facile thermally induced copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is demonstrated. To accomplish this, thermochemically reduced Cu(I) catalyst is adopted to trigger click cross-linking, resulting in a well-defined PEG network. The as-synthesized PEG-based hydrogel exhibits good mechanical performance with a tensile strength of 2.51 MPa, which is higher than the traditional PEG-based hydrogels prepared from CuSO4/NaSac-mediated or CuBr/ligand-catalyzed CuAAC. Moreover, in vitro cytotoxicity and in vivo porcine subcutaneous implantation tests demonstrate that the as-synthesized PEG-based hydrogel has a good biocompatibility and low toxicity, making it a promising candidate for the applications in biomedical devices and tissue engineering.
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