期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 218, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201600391
关键词
chitosan; films; permeability; polyelectrolytes; polysaccharides
资金
- JSPS KAKENHI [22550155, 25410178]
- Association for the Progress of New Chemistry (ASPRONC), Japan
- Grants-in-Aid for Scientific Research [25410178, 16K05799, 22550155] Funding Source: KAKEN
This study is performed in order to assess the molecular permeabilities of composite films of chondroitin sulfate C (CS) and chitosan (CHI) prepared by the hot press technique. Permeation behaviors are evaluated using horizontal diffusion cells and four substrates with different charges: methylene blue (MB), orange II (OR), l-tryptophan (Trp), and 4-methylumbelliferyl -d-galactopyranoside (MUG). Permeability coefficients, diffusion coefficients, and partition coefficients are calculated from permeation curves. When MB and OR are used as the permeants, permeability coefficients in solutions with higher pH or ionic strength are greater than in those with lower pH or ionic strength. Permeability coefficients at pH 5.9 at which Trp carries zero net charge are as follows: Trp > MB approximate to MUG > OR. The diffusion coefficients and partition coefficients obtained indicate that CS/CHI films permeate these molecules based on a partition mechanism at lower pH and a pore model at higher pH. These characteristics appear to reflect the unique microenvironment of films consisting of polyion complexes of oppositely charged polysaccharides.
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