The effectiveness of gluten-free dietary interventions: A systematic review

Celiac disease is a chronic autoimmune gastroenterological disorder in which the digestion of gluten leads to damage and constant inflammation in the small intestine. Moreover, there are associated physical and mental health problems related to celiac disease, i.e., a lower health-related quality of life and increased depression and anxiety symptoms. The only effective treatment for celiac disease is lifelong adherence to a gluten-free diet. However, researchers suggest that strict adherence to a gluten-free diet ranges from 42 to 80%, depending on the definition and method of assessment that was utilized. This review examines interventions designed for those who need to adhere to life-long dietary measures and their success in terms of increasing gluten-free dietary adherence and improving their health-related quality of life. In April 2022, the Scopus, Web of Science, PubMed and ProQuest databases were searched using the following terms: coeliac disease OR celiac disease AND gluten free diet AND intervention AND health related quality of life AND diabetes. Eight studies were suitable for this review. The studies were used to analyze different intervention techniques and their impact on gluten-free dietary adherence, quality of life, and the reasons for dietary nonadherence. The studies revealed statistically significant improvements in the knowledge base regarding celiac disease and the gluten-free diet, dietary adherence and quality-of-life satisfaction immediately after the intervention and at a three-month follow-up. Some studies were also focused on behavioral and cognitive aspects of nonadherence to dietary measures.

Automated summary

Celiac disease is a chronic autoimmune disorder that causes damage to the small intestine when gluten is consumed. It is associated with lower health-related quality of life and increased symptoms of depression and anxiety. Strict adherence to a gluten-free diet, the only effective treatment for celiac disease, ranges from 42 to 80%. This review examines interventions aimed at improving gluten-free dietary adherence and quality of life for individuals with celiac disease.