期刊
MACROMOLECULAR BIOSCIENCE
卷 16, 期 4, 页码 608-618出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500355
关键词
cellular infiltration; electrospinning; poly(epsilon-caprolactone); tissue engineering; vascular grafts
资金
- NSFC [81401534, 51173084, 81274128, 81371699, 31400833]
- Tianjin Research Program of Application Foundation and Advanced Technology [14JCQNJC13900]
- Program for ChangJiang Scholars and Innovative Research Team in University [IRT13023]
- China Postdoctoral Science Foundation [2014M561177]
- Science Funds of Tianjin Health and Family Planning Commission [2013KR08]
In this study, a three layered poly (epsilon-caprolactone) (PCL) graft (tPCL) was fabricated by electrospinning PCL and electrospraying poly (ethylene oxide) (PEO), which has a thin dense inner layer, a loose middle layer, and a dense outer layer. Regular PCL grafts (rPCL) with only a dense layer were used as control. In vivo evaluation was performed in rabbit carotid artery. Enhanced cell infiltration, rapid regeneration of endothelium and smooth muscle layers, and increased elastin deposition were observed within the tPCL graft wall. After 3 months, tPCL grafts showed faster PCL degradation than the rPCL grafts. Infiltrated macrophages in the tPCL grafts secreted higher level of monocyte chemoattractant protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) which enhanced vascular regeneration. In conclusion, the tPCL graft may be a useful vascular prosthesis and worth for further investigation.
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