期刊
MACROMOLECULAR BIOSCIENCE
卷 17, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600304
关键词
antimicrobial; medical safety; N-halamine; polymeric films; renewable
资金
- National Institute of Food and Agriculture (USDA-NIFA Award) [2015-68003-23411]
Antimicrobial polymeric films that are both mechanically robust and function renewable would have broad technological implications for areas ranging from medical safety and bioengineering to foods industry; however, creating such materials has proven extremely challenging. Here, a novel strategy is reported to create high-strength N-halamine incorporated poly(vinyl alcohol-co-ethylene) films (HAF films) with renewable antimicrobial activity by combining melt radical graft polymerization and reactive extrusion technique. The approach allows here the intrinsically rechargeable N-halamine moieties to be covalently incorporated into polymeric films with high biocidal activity and durability. The resulting HAF films exhibit integrated properties of robust mechanical strength, high transparency, rechargeable chlorination capability (>300 ppm), and long-term durability, which can effectively offer 3-5 logs CFU reduction against typical pathogenic bacterium Escherichia coli within a short contact time of 1 h, even at high organism conditions. The successful synthesis of HAF films also provides a versatile platform for exploring the applications of antimicrobial N-halamine moieties in a selfsupporting, structurally adaptive, and function renewable form.
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