期刊
MACROMOLECULAR BIOSCIENCE
卷 16, 期 5, 页码 635-646出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500440
关键词
biomedical application; oxidation-responsive material; ROS responsive polymer; stimuli-responsive polymer
资金
- National Natural Science Foundation of China [21574127, 51233004, 51390484, 51321062]
Reactive oxygen species (ROS) play important roles in cell signaling pathways, while increased production of ROS may disrupt cellular homeostasis, giving rise to oxidative stress and a series of diseases. Utilizing these cell-generated species as triggers for selective tuning polymer structures and properties represents a promising methodology for disease diagnosis and treatment. Recently, significant progress has been made in fabricating biomaterials including nanoparticles and macroscopic networks to interact with this dynamic physiological condition. These ROS-responsive platforms have shown potential in a range of biomedical applications, such as cancer targeted drug delivery systems, cell therapy platforms for inflammation related disease, and so on.
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