期刊
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
卷 46, 期 2, 页码 753-766出版社
SPRINGER
DOI: 10.1007/s13246-023-01248-1
关键词
3 T brain MRI; Brain conductivity; Compressed SENSE; Field mapping; RF shimming; Phase-based magnetic resonance electrical properties tomography
Magnetic resonance electrical properties tomography (MREPT) is a promising imaging technique for noninvasively measuring tissue conductivity and permittivity. This study investigated the repeatability of conductivity measurements using phase-based MREPT and the impact of compressed SENSE (CS) and RF shimming on measurement precision. The results showed that conductivity measurements using CS with bFFE phase were more repeatable and precise than those using TSE. RF shimming with better field mapping further improved the precision of the conductivity measures.
Magnetic resonance electrical properties tomography (MREPT) is an emerging imaging modality to noninvasively measure tissue conductivity and permittivity. Implementation of MREPT in the clinic requires repeatable measurements at a short scan time and an appropriate protocol. The aim of this study was to investigate the repeatability of conductivity measurements using phase-based MREPT and the effects of compressed SENSE (CS), and RF shimming on the precision of conductivity measurements. Conductivity measurements using turbo spin echo (TSE) and three-dimensional balanced fast field echo (bFFE) with CS factors were repeatable. Conductivity measurement using bFFE phase showed smaller mean and variance that those measured by TSE. The conductivity measurements using bFFE showed minimal deviation with CS factors up to 8, with deviation increasing at CS factors > 8. Subcortical structures produced less consistent measurements than cortical parcellations at higher CS factors. RF shimming using full slice coverage 2D dual refocusing echo acquisition mode (DREAM) and full coverage 3D dual TR approaches further improved measurement precision. BFFE is a more optimal sequence than TSE for phase-based MREPT in brain. Depending on the area of the brain being measured, the scan can be safely accelerated with compressed SENSE without sacrifice of precision, offering the potential to employ MREPT in clinical research and applications. RF shimming with better field mapping further improves precision of the conductivity measures.
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