期刊
MACROMOLECULAR BIOSCIENCE
卷 16, 期 8, 页码 1147-1157出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600028
关键词
biomaterials; hyaluronic acid; interpenetrating networks (IPN); poly(ethyl acrylate); scaffolds
资金
- ERANET-Neuron [PRI-PIMNEU-2011-1372]
- CICyT [MAT2011-28791-C03-02]
Hyaluronic acid (HA) provides many advantages to regenerative implants through its bioactive properties, but it also has many limitations as a biomaterial if it is not chemically modified. In order to overcome some of these limitations, HA has been combined with poly(ethyl acrylate) in the form of interpenetrating polymeric networks (IPNs), in which the HA network is crosslinked with divinyl sulfone. Scaffolds of this IPN have been produced through a template-leaching methodology, and their properties have been compared with those of single-network scaffolds made of either PEA or crosslinked HA. A fibroblast cell line has been used to assess the in vitro performance of the scaffolds, revealing good cell response and a differentiated behavior on the IPN surface when compared to the individual polymers. Altogether, the results confirm that this type of material offers an interesting microenvironment for cells, which can be further improved toward its potential use in medical implants.
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