4.8 Article

Advanced applications of strontium-containing biomaterials in bone tissue engineering

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MATERIALS TODAY BIO
卷 20, 期 -, 页码 -

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DOI: 10.1016/j.mtbio.2023.100636

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Strontium; Biomaterials; Bone tissue engineering; Osteoporosis

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This review provides a comprehensive overview of strontium-containing biomaterials and their current clinical use. Different types of biomaterials, including calcium phosphate, bioactive glass, and polymers, are discussed, and future outlook on the fabrication of the next-generation multifunctional and smart biomaterials is provided.
Strontium (Sr) and strontium ranelate (SR) are commonly used therapeutic drugs for patients suffering from osteoporosis. Researches have showed that Sr can significantly improve the biological activity and physicochemical properties of materials in vitro and in vivo. Therefore, a large number of strontium containing biomaterials have been developed for repairing bone defects and promoting osseointegration. In this review, we provide a comprehensive overview of Sr-containing biomaterials along with the current state of their clinical use. For this purpose, the different types of biomaterials including calcium phosphate, bioactive glass, and polymers are discussed and provided future outlook on the fabrication of the next-generation multifunctional and smart biomaterials.

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