期刊
MATERIALS TODAY BIO
卷 20, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtbio.2023.100612
关键词
Bacteriophages; M13; Phage display; Tissue regeneration; Cancer therapy
Bacteriophages, particularly M13 phages, have been extensively studied in the field of nanomedicine due to their unique biological advantages and engineering capabilities. The nanofiber-like morphology of M13 phages allows them to reach various target sites and self-assemble into multidimensional scaffolds. Genetic modifications enable the display of peptides and antibodies on the phages, making them valuable for precise and individualized medicine. Researchers have also used novel engineering approaches to enhance the bionanomaterial properties of M13 phages, leading to applications in drug delivery, biodetection, tissue regeneration, and targeted cancer therapy.
Bacteriophages (phages) are nanostructured viruses with highly selective antibacterial properties that have gained attention beyond eliminating bacteria. Specifically, M13 phages are filamentous phages that have recently been studied in various aspects of nanomedicine due to their biological advantages and more compliant engineering capabilities over other phages. Having nanofiber-like morphology, M13 phages can reach varied target sites and self-assemble into multidimensional scaffolds in a relatively safe and stable way. In addition, genetic modification of the coat proteins enables specific display of peptides and antibodies on the phages, allowing for precise and individualized medicine. M13 phages have also been subjected to novel engineering approaches, including phagebased bionanomaterial engineering and phage-directed nanomaterial combinations that enhance the bionanomaterial properties of M13 phages. In view of these features, researchers have been able to utilize M13 phages for therapeutic applications such as drug delivery, biodetection, tissue regeneration, and targeted cancer therapy. In particular, M13 phages have been utilized as a novel bionanomaterial for precisely mimicking natural tissue environment in order to overcome the shortage in tissue and organ donors. Hence, in this review, we address the recent studies and advances of using M13 phages in the field of nanomedicine as therapeutic agents based upon their characteristics as novel bionanomaterial with biomolecules displayed. This paper also emphasizes the novel engineering approach that enhances M13 phage's bionanomaterial capabilities. Current limitations and future approaches are also discussed to provide insight in further progress for M13 phage-based clinical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据