☆ 4.8 Article

Microfluidic synthesis of fibronectin-coated polydopamine nanocomplexes for self-supplementing tumor microenvironment regulation and MR imaging-guided chemo-chemodynamic-immune therapy

MATERIALS TODAY BIO (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Fibronectin-Coated Metal-Phenolic Networks for Cooperative Tumor Chemo-/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death

Yao Xu et al.

Summary: The development of a multifunctional theranostic nanoplatform based on doxorubicin-loaded tannic acid-iron networks is described. The platform shows excellent stability, strong targeting ability, and provides the advantages of cooperative immune therapy through iron-based chemodynamic therapy and doxorubicin chemotherapy.

ACS NANO (2022)

添加到收藏夹

Article Engineering, Biomedical

Silk fibroin-capped metal-organic framework for tumor-specific redox dyshomeostasis treatment synergized by deoxygenation-driven chemotherapy

Honglian Yu et al.

Summary: This study developed a nanocarrier based on a metal-organic framework nanosystem, which combined photodynamic therapy and chemodynamic therapy for tumor treatment. By disrupting the redox balance in tumor cells, this strategy significantly enhanced the anti-tumor effect and achieved almost complete tumor eradication in vivo.

ACTA BIOMATERIALIA (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment

Jitender Bariwal et al.

Summary: Cancer therapy faces challenges in drug delivery to cancer cells and non-selective killing of healthy cells. Nano-formulations show promising potential for targeted drug delivery. The shape and size of nanocarriers significantly impact their transport and internalization. Nanodiscs are desirable nano-formulations with enhanced anisotropic character and versatile functionalization potential.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

One Stone, Four Birds Ion Engineering to Fabricate Versatile Core-Shell Organosilica Nanoparticles for Intelligent Nanotheranostics

Saisai Yan et al.

Summary: In this study, an organosilica nanosystem activated by the acidic tumor microenvironment was constructed to accurately distinguish cancer cells and achieve efficient tumor diagnosis and treatment through multiple therapeutic mechanisms.

ACS NANO (2022)

添加到收藏夹

Article Engineering, Biomedical

Engineered nanomaterials for synergistic photo-immunotherapy

Ranran Guo et al.

Summary: Nanomaterial-synergized photodynamic therapy and photothermal therapy have significant advantages in fighting cancer. Researchers are now focusing on combining these therapies with immunotherapy by using nanomaterials to promote the maturation of immune cells and infiltration of immune cells, aiming to improve the treatment effectiveness.

BIOMATERIALS (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Multidimensional transitional metal-actuated nanoplatforms for cancer chemodynamic modulation

Yali Zhuang et al.

Summary: This article introduces the important role and chemodynamic modulation mechanisms of transitional metals in the tumor microenvironment, and systematically reviews the relevant antineoplastic nanosystems and applications. Finally, the opportunities and challenges of transitional metal-based chemodynamic modulation strategies in future development and clinical translation are discussed.

COORDINATION CHEMISTRY REVIEWS (2022)

添加到收藏夹

Article Chemistry, Physical

Endogenous Fe2+-activated ROS nanoamplifier for esterase-responsive and photoacoustic imaging-monitored therapeutic improvement

Sijin Xiang et al.

Summary: This study developed a PPA nanoamplifier by conjugating ART with PEG-functionalized Pd@Pt nanoplates, which showed specific intratumoral esterase-responsive ART release and enhanced ROS-mediated tumor therapy. The PPA nanoamplifier combined the in situ decomposition of ART's endoperoxide bridges by Fe2+ to superoxide anions and peroxidase-like enzymatic catalysis of endogenous H2O2 by PP to hydroxyl radicals, achieving amplified ROS signals and high-efficiency non-Fenton CDT. Additionally, PPA displayed GSH destruction potential and photoacoustic property for imaging-guided CDT.

NANO RESEARCH (2022)

添加到收藏夹

Article Chemistry, Physical

Biomimetic mesoporous polydopamine nanoparticles for MRI-guided photothermal-enhanced synergistic cascade chemodynamic cancer therapy

Nannan Zhang et al.

Summary: This study developed a novel nanomedicine platform for cancer therapy, combining MRI-guided photothermal therapy and enhanced chemodynamic therapy. It achieved more effective treatment by modulating the microenvironment, generating heat, and enhancing the efficacy of chemodynamic therapy.

NANO RESEARCH (2022)

添加到收藏夹

Review Oncology

Resistance to immune checkpoint blockade: Mechanisms, counter-acting approaches, and future directions

Alexander F. Haddad et al.

Summary: Immunotherapies, especially immune checkpoint blockade, have shown promise in treating cancer by unleashing the immune system against cancer cells. However, the efficacy varies across cancer types and some patients do not respond to these therapies. Understanding the underlying mechanisms of resistance is crucial for predicting response and tailoring personalized treatment paradigms.

SEMINARS IN CANCER BIOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Immunotherapy of Malignant Glioma by Noninvasive Administration of TLR9 Agonist CpG Nano-Immunoadjuvant

Jingjing Wei et al.

Summary: Polymersome-steered intravenous and intranasal brain delivery of CpG greatly boosts the immunotherapy of glioma, stimulating the maturation of dendritic cells and production of proinflammatory cytokines, thereby enhancing the therapeutic effects.

ADVANCED SCIENCE (2022)

添加到收藏夹

Article Engineering, Biomedical

TME-triggered MnSiO3@Met@GOx nanosystem for ATP dual-inhibited starvation/chemodynamic synergistic therapy

Jiayao Zhang et al.

BIOMATERIALS (2022)

添加到收藏夹

Article Engineering, Environmental

Full-active Cu2O/drug core/shell nanoparticles based on grafting from drug coordination polymerization combined with PD-1 blockade for efficient cancer therapy

Guanghui Hou et al.

Summary: In this study, a pioneering grafting from drug coordination polymerization strategy was proposed to develop a fully-coordinated and full-active Cu2O/drug core/shell nanoparticles for multimodal cancer therapy. The nanoplatform exhibited a rapid acid-responsive dissociation behavior and released chemotherapeutic drug cisplatin (CDDP) and photosensitizer indocyanine green (ICG) to achieve efficient triple combined photodynamic therapy/chemodynamic therapy/chemotherapy. The combination of the nanoplatform and alpha PD-1 effectively inhibited distal tumor growth, lung metastasis, and tumor recurrence through reprogramming tumor microenvironment and activating CD8+ T cell antitumor immunity. This study provides a new direction for the design of nanodrug delivery systems.

CHEMICAL ENGINEERING JOURNAL (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment

Zhan Zhang et al.

Summary: The novel polyphenol-based nanocomplex is designed to induce highly efficacious cancer immunosurveillance, localize therapy on the primary tumor, and minimize systemic side effects. It is prepared via metal-polyphenol coordination by encapsulating natural polyphenol gossypol and a newly synthesized polyphenol derivative polyethylene glycol-Chlorin e6 (Ce6). The nanocomplex can induce chemotherapeutic/photodynamic immunogenic cancer cell death upon laser irradiation, supported by dendritic cell maturation, secretion of inflammatory cytokines, and inhibition of distant untreated tumors.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma

Tingting Xiao et al.

Summary: The study introduces a multifunctional polymer nanogel camouflaged with macrophage membranes for MR imaging-guided chemotherapy of glioma. The nanogel exhibits dual pH and redox-responsive release profiles, enhancing chemotherapy/CDT efficacy.

ACS NANO (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic-Synergized Multimodal Therapy

Yaofeng Zhou et al.

Summary: Various strategies have been developed to increase the efficiency of the intratumoral Fenton reaction in chemodynamic therapy (CDT), enhancing the therapeutic efficacy. The introduction of reinforcement strategies can improve treatment efficiency and promote the development of enhanced CDT-based multimodal anticancer therapies.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Missing-Linker-Assisted Artesunate Delivery by Metal-Organic Frameworks for Synergistic Cancer Treatment

Dongdong Wang et al.

Summary: This study presents the development of an ATS nanomedicine through self-assembly with metal-organic frameworks (MOFs), utilizing defects in MOFs caused by missing linkers to enhance the biological stability and tumor accumulation of ATS. In the presence of intracellular HCO3-, Mn2+ acts as a catalyst to promote the bicarbonate-activated H2O2 system, oxidizing ATS to generate reactive oxygen species and inducing oxidative death in cancer cells.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Engineering, Biomedical

A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy

Jian Chen et al.

Summary: The carrier-free Fe(III)-ART nanoparticles, triggered by intracellular GSH, release ART and Fe3+, catalyzing the endoperoxide of ART to generate C-centered free radicals. This application demonstrates superior anticancer efficacy and contributes to activatable MRI-guided chemodynamic therapy.

BIOMATERIALS (2021)

添加到收藏夹

Article Engineering, Biomedical

Multifunctional carbon monoxide nanogenerator as immunogenic cell death drugs with enhanced antitumor immunity and antimetastatic effect

Xiao Xiao et al.

Summary: This study discusses the use of CO gas therapy to enhance anti-tumor immunity, integrating gas therapy and immunotherapy into a photocatalytic nanogenerator. The approach effectively induces immunogenic cell death (ICD), boosts immune responses, and activates immune cells, leading to an enhanced immune effect when combined with Immune Checkpoint Blockade (ICB). This in-situ photocatalytic CO therapy strategy avoids toxicity from CO leakage and offers a new method for designing novel ICD inducers.

BIOMATERIALS (2021)

添加到收藏夹

Article Engineering, Biomedical

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Boyi Niu et al.

Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.

BIOMATERIALS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

添加到收藏夹

Article Engineering, Biomedical

Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy

Lisi Xie et al.

Summary: The study created a novel phenolic inducer through self-assembly, which enhances cell death triggered by doxorubicin and accelerates immunogenic cell death (ICD) induction, leading to increased infiltration of tumor-specific T cells and improved tumor response to PD-1 checkpoint blockade immunotherapy.

BIOMATERIALS (2021)

添加到收藏夹

Article Materials Science, Biomaterials

Nanoparticle delivery of a triple-action Pt(iv) prodrug to overcome cisplatin resistance via synergistic effect

Peng Xie et al.

Summary: This study reports a triple action nanoplatinum drug based on artesunate and cantharidin, which enhances ROS generation, induces DNA damage, and inhibits DNA repair to achieve a high-efficiency killing effect in a single tumor cell.

BIOMATERIALS SCIENCE (2021)

添加到收藏夹

Article Engineering, Biomedical

Mechanistic insights into the adsorption and bioactivity of fibronectin on surfaces with varying chemistries by a combination of experimental strategies and molecular simulations

Lijing Hao et al.

Summary: The research findings indicate that different surface chemical properties impact the adsorption and cell behavior of Fn, resulting in varied bioactivities. SAMs-CH3 adsorb Fn via hydrophobic interactions with low bioactivity, SAMs-NH2 and SAMs-COOH efficiently adsorb Fn through multiple interactions, showing good bioactivity, while SAMs-OH, despite poor adsorption, also has some influence on the bioactivity of Fn.

BIOACTIVE MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Visible-Light-Triggered Prodrug Nanoparticles Combine Chemotherapy and Photodynamic Therapy to Potentiate Checkpoint Blockade Cancer Immunotherapy

Jiwoong Choi et al.

Summary: Immune checkpoint blockade is a promising approach for cancer immunotherapy, but many patients do not respond due to the immunosuppressive tumor microenvironment. This study proposes visible-light-triggered prodrug nanoparticles (LT-NPs) to reverse the immunosuppressive tumor microenvironment and enhance checkpoint blockade immunotherapy, showing promising results in tumor models.

ACS NANO (2021)

添加到收藏夹

Review Engineering, Biomedical

Microfluidic formulation of nanoparticles for biomedical applications

Sarah J. Shepherd et al.

Summary: Nanomedicine has advanced significantly in clinical applications, with microfluidic devices showing potential for generating reproducible nanoparticle formulations. These formulations enhance biomedical applications with controlled physical properties, pointing towards future production scale-independent formulations through parallelization and multi-step reactions.

BIOMATERIALS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy

Wei Qiu et al.

Summary: Using tumor-specific activated calcified nanoparticles as a multifunctional nanoplatform for oxidative stress amplification of anticancer drugs can enhance chemotherapy effectiveness and induce immunogenic cell death, while inhibiting tumor cell invasion.

THERANOSTICS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Yuxuan Xiong et al.

Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Physical

GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system

Amin Zhang et al.

NANO RESEARCH (2020)

添加到收藏夹

Article Nanoscience & Nanotechnology

Tumor-Specific Endogenous FeII-Activated, MRI-Guided Self-Targeting Gadolinium-Coordinated Theranostic Nanoplatforms for Amplification of ROS and Enhanced Chemodynamic Chemotherapy

Zhongxiong Fan et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multistage Sensitive NanoCRISPR Enable Efficient Intracellular Disruption of Immune Checkpoints for Robust Innate and Adaptive Immune Coactivation

Ning Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy

Lisen Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Review Engineering, Biomedical

Redox-Responsive Self-Assembled Nanoparticles for Cancer Therapy

Dandan Li et al.

ADVANCED HEALTHCARE MATERIALS (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Peng Mi

THERANOSTICS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Review Oncology

Targeting Ferroptosis to Iron Out Cancer

Behrouz Hassannia et al.

CANCER CELL (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Intratumoral fate of functional nanoparticles in response to microenvironment factor: Implications on cancer diagnosis and therapy

Jinrong Peng et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

被撤回的出版物: Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy (Retracted article. See vol. 9, pg. 755, 2023)

Kaiyuan Ni et al.

CHEM (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Transformable Nanoparticle-Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple-Negative Breast Cancer Immunotherapy

Chenfeng Xu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Novel Tumor-Microenvironment-Based Sequential Catalytic Therapy by Fe(II)-Engineered Polydopamine Nanoparticles

Yuda Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Construction of Dually Responsive Nanotransformers with Nanosphere-Nanofiber-Nanosphere Transition for Overcoming the Size Paradox of Anticancer Nanodrugs

Hao-Ran Jia et al.

ACS NANO (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Microfluidic Sonication To Assemble Exosome Membrane-Coated Nanoparticles for Immune Evasion-Mediated Targeting

Chao Liu et al.

NANO LETTERS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Facile Ion-Doping Strategy To Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics

Jing Bai et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Engineering, Environmental

Single phase microreactor for the continuous, high-temperature synthesis of < 4 nm superparamagnetic iron oxide nanoparticles

Laura Uson et al.

CHEMICAL ENGINEERING JOURNAL (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Towards rational design of RAD51-targeting prodrugs: platinum(IV)-artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells

Shuren Zhang et al.

CHEMICAL COMMUNICATIONS (2018)

添加到收藏夹

Review Oncology

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

Mizuki Nishino et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

添加到收藏夹

Review Chemistry, Physical

Microfluidic Synthesis of Nanomaterials for Biomedical Applications

Li-Li Li et al.

SMALL METHODS (2017)

添加到收藏夹

Article Engineering, Biomedical

A nano-scaled and multi-layered recombinant fibronectin/cadherin chimera composite selectively concentrates osteogenesis-related cells and factors to aid bone repair

Junchao Xing et al.

ACTA BIOMATERIALIA (2017)

添加到收藏夹

Article Chemistry, Analytical

Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios

Lu Zhang et al.

ANALYTICAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Chen Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Article Materials Science, Biomaterials

Synthesis of mesoporous materials as nano-carriers for an antimalarial drug

Saliu Alao Amolegbe et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery

Lu Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Article Engineering, Biomedical

Microfluidic assisted one-step fabrication of porous silicon@acetalated dextran nanocomposites for precisely controlled combination chemotherapy

Dongfei Liu et al.

BIOMATERIALS (2015)

添加到收藏夹

Article Engineering, Biomedical

Dihydroartemisinin and transferrin dual-dressed nano-graphene oxide for a pH-triggered chemotherapy

Lijuan Liu et al.

BIOMATERIALS (2015)

添加到收藏夹

Article Engineering, Biomedical

Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacy

Huijuan Zhang et al.

BIOMATERIALS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

pH-Activated Near-Infrared Fluorescence Nanoprobe Imaging Tumors by Sensing the Acidic Microenvironment

Cong Li et al.

ADVANCED FUNCTIONAL MATERIALS (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Microfluidic platform for controlled synthesis of polymeric nanoparticles

Rohit Karnik et al.

NANO LETTERS (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.