期刊
MATERIALS TODAY BIO
卷 20, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtbio.2023.100650
关键词
Oxidized sodium alginate; Carboxyethyl chitosan; pH-responsive; Bioadhesives; Wound healing
We developed a dual-cross-linked pH-responsive hydrogel based on CAO containing Ag NPs functionalized with ATR. The hydrogel showed improved adhesive and compression strength, as well as pH-sensitivity and antibacterial properties. It also exhibited hemostatic abilities and cytocompatibility, making it a promising candidate for smart wound bioadhesives.
Here we develop and characterize a dual-cross-linked pH-responsive hydrogel based on the carboxyethyl chitosan-oxidized sodium alginate (CAO) containing silver nanoparticles (Ag NPs) functionalized with tannic acid/red cabbage (ATR). This hybrid hydrogel is formed via covalent and non-covalent cross-linking. The adhesive strength measured in contact with cow skin and compression strength is measured more than 3 times higher than that of CAO. Importantly, the incorporation of 1 wt% ATR into CAO significantly enhances the compression strength of CAO from 35.1 & PLUSMN; 2.1 kPa to 97.5 & PLUSMN; 2.9 kPa. Moreover, the cyclic compression tests confirm significantly higher elastic behavior of CAO after the addition of ATR-functionalized NPs to CAO. The CAO/ATR hydrogel is pH -sensitive and indicated remarkable color changes in different buffer solutions. The CAO/ATR also shows improved hemostatic properties and reduced clotting time compared to the clotting time of blood in contact with CAO hydrogel. In addition, while CAO/ATR is effective in inhibiting the growth of both Gram-positive and Gram-negative bacteria, CAO is only effective in inhibiting the growth of Gram-positive bacteria. Finally, the CAO/ATR hydrogel is cytocompatible with L929 fibroblasts. In summary, the resulting CAO/ATR hydrogel shows promising results in designing and constructing smart wound bioadhesives with high cytocompatibility, antibacterial properties, blood coagulation ability, and fast self-healing properties.
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