☆ 4.2 Review

Gastrointestinal Dysfunction in Parkinson's Disease: Neuro-Gastroenterology Perspectives on a Multifaceted Problem

JOURNAL OF MOVEMENT DISORDERS (2023)

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Review Gastroenterology & Hepatology

Epidemiology and Healthcare Utilization in Patients With Gastroparesis: A Systematic Review

Saam Dilmaghani et al.

Summary: This study systematically reviewed the epidemiology of gastroparesis (GP), including prevalence, incidence, etiologies, and hospitalizations. Thirteen studies were included, which showed varying rates of GP in different countries and years. Females and patients with diabetes were more susceptible to GP. Rates of hospitalizations and emergency department visits for GP are increasing, and mortality rates for GP patients are higher compared with the general population.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Review Anesthesiology

Peri-operative management of patients with Parkinson's disease

R. L. H. Yim et al.

Summary: Parkinson's disease patients have a higher risk of peri-operative complications, necessitating multidisciplinary management and specialized care. Continuous dopaminergic treatment, peri-operative disease pathway development, and telemedicine are improving peri-operative care. Management for advanced Parkinson's disease is evolving with potential for integrated care and changes in anaesthetic management.

ANAESTHESIA (2022)

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Review Gastroenterology & Hepatology

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis

Alexander C. Ford et al.

Summary: The study suggests that H. pylori eradication therapy can lead to both cure and improvement of symptoms in patients with functional dyspepsia, although the benefit is modest. Successful eradication of H. pylori is associated with a greater effect, but also with more adverse events.

GUT (2022)

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Article Gastroenterology & Hepatology

Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management

Daniel Bushyhead et al.

Summary: The concept of small intestinal bacterial overgrowth (SIBO) explains the cause of maldigestion and malabsorption. With the development of diagnostic testing, the methods for diagnosing SIBO have evolved from small bowel culture to breath tests and culture-independent microbial analytics. The availability of breath tests has led to an expansion in the diagnosis of SIBO and the associated clinical symptoms. However, issues with the specificity of breath tests have raised doubts about the role of SIBO in certain clinical scenarios. The hope is to use modern molecular microbiology to study the human small intestinal microbiome in order to provide an objective basis for diagnosing SIBO.

GASTROENTEROLOGY (2022)

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Review Clinical Neurology

A multinational consensus on dysphagia in Parkinson's disease: screening, diagnosis and prognostic value

Giuseppe Cosentino et al.

Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor dysfunction, with dysphagia being a common yet often underdiagnosed symptom. A multinational group of experts conducted a systematic review and consensus conference to provide guidance on the screening, diagnosis, and impact of dysphagia on the prognosis and quality of life of PD patients. The consensus statements offer a framework for timely detection and accurate diagnosis of dysphagia in PD.

JOURNAL OF NEUROLOGY (2022)

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Article Gastroenterology & Hepatology

Epidemiological trends of gastrointestinal and liver diseases in Malaysia: A single-center observational study

Sze Zee Lim et al.

Summary: This study retrospectively analyzed outpatient data from a specialist clinic and found that there are differences in the prevalence of gastrointestinal and liver diseases among different ethnic groups. Indian patients were more likely to be diagnosed with inflammatory bowel disease, while Malay and Indian patients had a higher prevalence of non-alcoholic fatty liver disease (NAFLD).

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Clinical Neurology

Effectiveness of an herbaceous derivatives, PHGG, plus sodium hyaluronate in the treatment of chronic constipation in patients with Parkinson's disease: a pilot study

Laura Vacca et al.

Summary: The study investigated the efficacy and safety of PHGG plus hyaluronate (PHGG+) in PD patients suffering from constipation, showing minimal yet significant improvement in symptoms. PHGG+ was found to be safe and well tolerated, with data suggesting its efficacy in alleviating constipation in PD patients.

NEUROLOGICAL SCIENCES (2022)

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Article Clinical Neurology

Gastrointestinal Dysfunction Impact on Life Quality in a Cohort of Russian Patients with Parkinson's Disease I-III H&Y Stage

A. A. Pilipovich et al.

Summary: The study aims to assess the impact of gastrointestinal dysfunction and its symptoms on the quality of life of Parkinson's disease patients. The results show that depression and gastrointestinal dysfunction have a significant negative influence on the patients' quality of life, especially constipation and abdominal pain.

PARKINSONS DISEASE (2022)

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Article Neurosciences

Probiotics synergized with conventional regimen in managing Parkinson's disease

Hairong Sun et al.

Summary: The study found that co-administration of the probiotic Probio-M8 can improve sleep quality, alleviate anxiety, and gastrointestinal symptoms in patients with Parkinson's disease. It also has an impact on the host's gut microbiome, gut microbial metabolic potential, and serum metabolites.

NPJ PARKINSONS DISEASE (2022)

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Article Gastroenterology & Hepatology

ACG Clinical Guideline: Gastroparesis

Michael Camilleri et al.

Summary: The guidelines summarize the diagnosis and management of gastroparesis in adults, representing the official practice recommendations of the American College of Gastroenterology.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

British Society of Gastroenterology guidelines on the management of functional dyspepsia

Christopher J. Black et al.

Summary: This research aims to review and summarize the current evidence on functional dyspepsia, provide a practical framework for evidence-based diagnosis and treatment of patients, and provide specific recommendations based on the GRADE system. The study also considers the development of novel treatment methods and highlights areas of unmet need and priorities for future research.

GUT (2022)

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Article Clinical Neurology

Gastrointestinal Motility and Response to Levodopa in Parkinson's Disease: A Proof-of-Concept Study

Delaram Safarpour et al.

Summary: This study aimed to investigate whether altered segmental gastrointestinal transit time (GITT) correlates with clinical response and plasma levodopa concentration (PLC) variability in patients with Parkinson's disease. The results showed no significant difference in GITT between typical and erratic responders. Additionally, Small Intestinal Bacterial Overgrowth (SIBO) was positive in half of the erratic responders and negative in most typical responders.

MOVEMENT DISORDERS (2022)

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Review Clinical Neurology

The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic

Ai Huey Tan et al.

Summary: The close bidirectional link between the brain and the gut in Parkinson disease has led to a paradigm shift in neurology. Gut-related factors play significant roles in the development, progression, and treatment responses of Parkinson disease, and could potentially be targeted for therapeutics. The gut microbiome, in particular, has been highlighted as an important factor. Future directions for the field include further understanding of the gut-brain axis and addressing current knowledge gaps and challenges.

NATURE REVIEWS NEUROLOGY (2022)

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Review Geriatrics & Gerontology

Management of dysphagia and gastroparesis in Parkinson's disease in real-world clinical practice - Balancing pharmacological and non-pharmacological approaches

Roongroj Bhidayasiri et al.

Summary: Patients with Parkinson's disease commonly experience gastrointestinal issues, including constipation and upper GI issues like dysphagia and gastroparesis, which are often overlooked. Timely and effective management of upper GI issues is crucial for improving the quality of life and medication effectiveness in PD patients.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Clinical Neurology

Association Between Microbial Tyrosine Decarboxylase Gene and Levodopa Responsiveness in Patients With Parkinson Disease

Yi Zhang et al.

Summary: The abundance of microbial tyrDC gene may serve as a potential biomarker for levodopa responsiveness in Parkinson's disease. Predicting levodopa responsiveness based on tyrDC gene abundance showed good calibration and discrimination in both cross-validation and external validation. Novel strategies targeting the tyrDC gene could provide new approaches for personalized levodopa treatment.

NEUROLOGY (2022)

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Article Clinical Neurology

Probiotics for constipation and gut microbiota in Parkinson's disease

Yitong Du et al.

Summary: This study suggests that probiotic treatment can effectively improve constipation symptoms in Parkinson's disease patients and have a positive impact on the gut microbiota.

PARKINSONISM & RELATED DISORDERS (2022)

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Review Clinical Neurology

The prevalence and associated factors of dysphagia in Parkinson's disease: A systematic review and meta-analysis

Siyuan Gong et al.

Summary: This systematic review and meta-analysis evaluates the prevalence of dysphagia in Parkinson's disease (PD) and its associated factors. The findings indicate that dysphagia occurs in more than one-third of PD patients, with instrumental examination showing a higher prevalence. The prevalence of dysphagia varies across different regions, with Oceania having the highest prevalence and America having the lowest. Dysphagia in PD is associated with several demographic characteristics, PD-related characteristics, motor symptoms, non-motor symptoms, as well as decreased quality of life.

FRONTIERS IN NEUROLOGY (2022)

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Article Gastroenterology & Hepatology

Asian-Pacific consensus on small intestinal bacterial overgrowth in gastrointestinal disorders: An initiative of the Indian Neurogastroenterology and Motility Association

Uday C. Ghoshal et al.

Summary: Small intestinal bacterial overgrowth (SIBO) is a common but often under-diagnosed condition in the clinical setting. In this study, experts from the Asian-Pacific region developed an evidence-based practice guideline for the management of SIBO using a modified Delphi process. The guideline provides consensus statements in different areas to guide clinical practice, teaching, and research on SIBO.

INDIAN JOURNAL OF GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Ami D. Sperber et al.

Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom

Yizhou Ye et al.

Summary: Through analysis of the CPRD database, it was found that the standardized prevalence of gastroparesis in 2016 was 13.8 per 100,000 persons, while the standardized incidence increased from 1.5 per 100,000 person-years in 2004 to 1.9 in 2016. Diabetic gastroparesis and idiopathic gastroparesis were the most common disease etiologies, with diabetic gastroparesis patients having a significantly higher risk of mortality after diagnosis compared to idiopathic gastroparesis patients.

GUT (2021)

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Review Gastroenterology & Hepatology

Systematic review and network meta-analysis: efficacy of drugs for functional dyspepsia

Alexander C. Ford et al.

Summary: Through a systematic review and network meta-analysis, we found that tricyclic antidepressants (TCAs) are effective treatments for FD, and sulpiride or levosulpiride also show high efficacy. However, TCAs are more likely to cause adverse events.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

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Review Clinical Neurology

A Pragmatic Approach to the Perioperative Management of Parkinson's Disease

Abhishek Lenka et al.

Summary: This review comprehensively discusses the challenges in perioperative management of PD patients, including medication reconciliation, administration of dopaminergic medications, choice of anesthesia, respiratory issues, dysautonomia, and emphasizes the importance of multidisciplinary teamwork in preventing and managing perioperative complications.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2021)

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Article Clinical Neurology

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics

Ai Huey Tan et al.

Summary: The study found significant differences in gut microbiome and metabolome between Parkinson's disease (PD) patients and healthy controls, including changes in bioactive molecules and other compounds. Cognitive impairment, low BMI, and other factors in PD patients were associated with fecal metabolome composition differences.

ANNALS OF NEUROLOGY (2021)

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Article Gastroenterology & Hepatology

The epidemiology and quality of life of functional gastrointestinal disorders according to Rome III vs Rome IV criteria: A cross-sectional study in primary care

Kee-Huat Chuah et al.

Summary: The Rome IV criteria led to a decrease in the frequency of IBS and an increase in functional diarrhea compared to the Rome III criteria, while the frequency of FD and FC remained unchanged. Regardless of criteria, FGIDs significantly impacted healthcare burden and HRQOL.

JOURNAL OF DIGESTIVE DISEASES (2021)

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Article Gastroenterology & Hepatology

Digital Rectal Examination Is a Valuable Bedside Tool for Detecting Dyssynergic Defecation: A Diagnostic Study and a Meta-Analysis

Jie Liu et al.

Summary: This study revealed the potential value of digital rectal examination (DRE) in screening dyssynergic defecation (DD), with acceptable sensitivity and specificity compared to physiological tests. The study also highlights the importance of DRE as a valuable tool in clinical practice.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Evaluation of fecal microbiota transplantation in Parkinson's disease patients with constipation

Xiao-yi Kuai et al.

Summary: The study showed that fecal microbiota transplantation (FMT) is effective in improving gastrointestinal dysfunction in Parkinson's disease patients, significantly reducing both motor and non-motor symptoms, regulating the gut microbiota structure, restoring intestinal bacterial overgrowth, and improving constipation symptoms.

MICROBIAL CELL FACTORIES (2021)

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Article Clinical Neurology

Onset of Skin, Gut, and Genitourinary Prodromal Parkinson's Disease: A Study of 1.5 Million Veterans

Gregory D. Scott et al.

Summary: Through the study, it was found that gastrointestinal, genitourinary, and skin disorders appear decades before the diagnosis of Parkinson's disease, emphasizing their potential as early diagnostic testing and understanding pathogenesis. The estimated onset time is related to the association with certain diseases and diagnosis time, with constipation and urinary dysfunction having longer onset times.

MOVEMENT DISORDERS (2021)

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Editorial Material Gastroenterology & Hepatology

The challenges of implementing evidence-based therapy for irritable bowel syndrome in Asia

Kee-Huat Chuah et al.

JGH OPEN (2021)

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Article Clinical Neurology

Fecal microbiota transplant as a potential treatment for Parkinson's disease-A case series

Arik Segal et al.

Summary: The study found that fecal microbiota transplant may be safe and effective in improving constipation, motor, and non-motor symptoms in Parkinson's disease patients. However, further research is needed to confirm these findings and assess long-term efficacy and safety, including through large scale randomized controlled trials.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Article Gastroenterology & Hepatology

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis

Jolien Schol et al.

Summary: A multinational group of European experts summarized the current consensus on the definition, symptom characteristics, pathophysiology, diagnosis, and management of gastroparesis, but there is still no consensus on underlying pathophysiology and treatment methods.

NEUROGASTROENTEROLOGY AND MOTILITY (2021)

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Review Neurosciences

Gastroparesis in Parkinson Disease: Pathophysiology, and Clinical Management

Heithem Soliman et al.

Summary: Patients with Parkinson's disease often experience gastrointestinal symptoms like gastroparesis, which can significantly impact their quality of life. These symptoms may precede motor symptoms and are linked to the presence of α-synuclein aggregates in the enteric nervous system. Proper diagnosis and treatment, including dietary modifications and pharmacologic agents, are crucial for managing these gastrointestinal issues in PD patients.

BRAIN SCIENCES (2021)

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Article Neurosciences

Early constipation predicts faster dementia onset in Parkinson's disease

M. Camacho et al.

Summary: Constipation severity in early Parkinson's disease is significantly associated with progression to dementia, indicating that constipation may predict accelerated neurodegenerative pathology.

NPJ PARKINSONS DISEASE (2021)

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Article Clinical Neurology

Cohort Study in Parkinsonism Delayed Transit, Accelerated Gastric Emptying, and Prodromal Dysmotility

Katayoun Khoshbin et al.

Summary: Parkinsonian patients were found to have abnormal gastric emptying and slow colonic transit, with accelerated gastric emptying also being common. Parkinson's disease patients had longer disease duration and higher levodopa equivalent daily dose. Objective assessment revealed that gut dysmotility could precede the motor onset of parkinsonism.

NEUROLOGY-CLINICAL PRACTICE (2021)

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Article Clinical Neurology

Health-Related Quality of Life for Parkinson's Disease Patients and Their Caregivers

Michal Lubomski et al.

Summary: The study found that Parkinson's disease patients reported significantly decreased health-related quality of life (HRQoL), with factors such as unemployment, the need for social support services, REM sleep behavior disorder, impulse control disorders, and features suggestive of increasing disease severity contributing to lower HRQoL. Additionally, decreased physical activity, chronic pain, depression, constipation, and upper gastrointestinal dysfunction were associated with reduced HRQoL in PD patients.

JOURNAL OF MOVEMENT DISORDERS (2021)

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Review Gastroenterology & Hepatology

Probiotics for Parkinson's disease: Current evidence and future directions

Ai Huey Tan et al.

Summary: The gut-brain axis plays a crucial role in Parkinson's disease, with probiotics potentially aiding in improving gut health and slowing down neurodegeneration. Probiotics have diverse functions, such as pathogen inhibition, microbiome regulation, and immunomodulation, which may be important in PD therapy.

JGH OPEN (2021)

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Article Gastroenterology & Hepatology

Novel concepts in the pathophysiology and treatment of functional dyspepsia

Lucas Wauters et al.

GUT (2020)

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Article Gastroenterology & Hepatology

European society of neurogastroenterology and motility guidelines on functional constipation in adults

Jordi Serra et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Review Gastroenterology & Hepatology

Breath Tests for the Non-invasive Diagnosis o Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis

Giuseppe Losurdo et al.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Article Gastroenterology & Hepatology

ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth

Mark Pimentel et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Review Gastroenterology & Hepatology

Mechanisms, Evaluation, and Management of Chronic Constipation

Adil E. Bharucha et al.

GASTROENTEROLOGY (2020)

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Article Clinical Neurology

Gastrointestinal dysfunction in Parkinson's disease

Michal Lubomski et al.

JOURNAL OF NEUROLOGY (2020)

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Article Clinical Neurology

Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease

Jacob D. Jones et al.

PARKINSONISM & RELATED DISORDERS (2020)

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Review Clinical Neurology

Clinical implications of gastric complications on levodopa treatment in Parkinson's disease

Ronald F. Pfeiffer et al.

PARKINSONISM & RELATED DISORDERS (2020)

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Article Clinical Neurology

Double-Blind, Randomized,Placebo-ControlledTrial ofDA-9701 in Parkinson's Disease:PASS-GIStudy

Ji-Hyun Choi et al.

MOVEMENT DISORDERS (2020)

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Article Clinical Neurology

Progressive and accelerated weight and body fat loss in Parkinson's disease: A three-year prospective longitudinal study

Voon Wei Yong et al.

PARKINSONISM & RELATED DISORDERS (2020)

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Article Multidisciplinary Sciences

Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: A randomised controlled trial

Azliza Ibrahim et al.

PLOS ONE (2020)

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Review Food Science & Technology

Sialorrhea in Parkinson's Disease

Jonathan Isaacson et al.

TOXINS (2020)

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Review Clinical Neurology

Emergencies and critical issues in Parkinson's disease

Cristina Simonet et al.

PRACTICAL NEUROLOGY (2020)

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Article Clinical Neurology

Increased dose of carbidopa with levodopa and entacapone improves off time in a randomized trial

Claudia Trenkwalder et al.

NEUROLOGY (2019)

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Article Gastroenterology & Hepatology

Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study

Florencia Carbone et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

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Editorial Material Gastroenterology & Hepatology

Symptoms and the small intestinal microbiome - the unknown explored

Eamonn M. M. Quigley

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

Vayu Maini Rekdal et al.

SCIENCE (2019)

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Article Multidisciplinary Sciences

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

George B. Saffouri et al.

NATURE COMMUNICATIONS (2019)

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Article Clinical Neurology

Colonic transit, high-resolution anorectal manometry and MRI defecography study of constipation in Parkinson's disease

Eduardo De Pablo-Fernandez et al.

PARKINSONISM & RELATED DISORDERS (2019)

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Article Gastroenterology & Hepatology

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis

Allen A. Lee et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Clinical Neurology

Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review

Klaus Seppi et al.

MOVEMENT DISORDERS (2019)

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Article Multidisciplinary Sciences

Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease

Sebastiaan P. van Kessel et al.

NATURE COMMUNICATIONS (2019)

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Article Clinical Neurology

A Randomized, Double-Blind, Placebo-Controlled Trial of Camicinal in Parkinson's Disease

Sarah L. Marrinan et al.

MOVEMENT DISORDERS (2018)

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Article Gastroenterology & Hepatology

Advances in the diagnosis and classification of gastric and intestinal motility disorders

Jutta Keller et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Letter Clinical Neurology

Small intestinal bacterial overgrowth in Parkinson's disease: Tribulations of a trial

Joaquin A. Vizcarra et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Clinical Neurology

DA-9701 on gastric motility in patients with Parkinson's disease: A randomized controlled trial

Cheol Min Shin et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Clinical Neurology

Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease

Ai Huey Tan et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Review Clinical Neurology

Gastric emptying in Parkinson's disease - A mini-review

Karoline Knudsen et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Clinical Neurology

Helicobacter pylori infection is associated with an increased risk of Parkinson's disease: A population-based retrospective cohort study

Huei-Kai Huang et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Review Clinical Neurology

Gastrointestinal Dysfunction in Parkinson's Disease

Ronald F. Pfeiffer

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2018)

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Article Medicine, General & Internal

Gastroparesis

Michael Camilleri et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

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Letter Clinical Neurology

Linaclotide and Prucalopride for Management of Constipation in Patients with Parkinsonism

Maria Eliza Freitas et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2018)

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Review Clinical Neurology

Does Parkinson's disease start in the gut?

Arthur Lionnet et al.

ACTA NEUROPATHOLOGICA (2018)

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Review Clinical Neurology

Constipation in Parkinson's Disease: Subjective Symptoms, Objective Markers, and New Perspectives

Karoline Knudsen et al.

MOVEMENT DISORDERS (2017)

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Review Gastroenterology & Hepatology

Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

James K. Y. Hooi et al.

GASTROENTEROLOGY (2017)

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Review Gastroenterology & Hepatology

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy

Uday C. Ghoshal et al.

GUT AND LIVER (2017)

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Review Clinical Neurology

A practical review of gastrointestinal manifestations in Parkinson's disease

Andrew Su et al.

PARKINSONISM & RELATED DISORDERS (2017)

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Article Clinical Neurology

Pilot cohort study of endoscopic botulinum neurotoxin injection in Parkinson's disease

George Triadafilopoulos et al.

PARKINSONISM & RELATED DISORDERS (2017)

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Article Clinical Neurology

A randomized trial of relamorelin for constipation in Parkinson's disease (MOVE-PD): Trial results and lessons learned

Ronald F. Pfeiffer et al.

PARKINSONISM & RELATED DISORDERS (2017)

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Article Neurosciences

Gastrointestinal Transit Time in Parkinson's Disease Using a Magnetic Tracking System

Karoline Knudsen et al.

JOURNAL OF PARKINSONS DISEASE (2017)

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Article Medicine, General & Internal

Chronic constipation

Michael Camilleri et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Medicine, General & Internal

Functional dyspepsia

Paul Enck et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Gastroenterology & Hepatology

Clinical and manometric characteristics of patients with Parkinson's disease and esophageal symptoms

A. Su et al.

DISEASES OF THE ESOPHAGUS (2017)

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Review Neurosciences

Imaging Parkinson's disease below the neck

Per Borghammer et al.

NPJ PARKINSONS DISEASE (2017)

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Article Clinical Neurology

Autonomic Dysfunction in Early Parkinson's Disease: Results from the United Kingdom Tracking Parkinson's Study

Naveed Malek et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2017)

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Article Gastroenterology & Hepatology

Utility of the wireless motility capsule and lactulose breath testing in the evaluation of patients with Parkinson's disease who present with functional gastrointestinal symptoms

Andrew Su et al.

BMJ OPEN GASTROENTEROLOGY (2017)

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Review Gastroenterology & Hepatology

Review article: dyssynergic defaecation and biofeedback therapy in the pathophysiology and management of functional constipation

G. R. Skardoon et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2017)

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Review Gastroenterology & Hepatology

ACG and CAG Clinical Guideline: Management of Dyspepsia

Paul M. Moayyedi et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus

Ali Rezaie et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth

L. Gatta et al.

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Levodopa Does Not Worsen Gastric Emptying in Parkinson's Disease

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Drooling in Parkinson's disease: A review

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Small intestinal bacterial overgrowth in Parkinson's disease

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High Prevalence of Gastroesophageal Reflux Disease in Parkinson's Disease: A Questionnaire-Based Study

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Treatment for Helicobacter pylori infection and risk of parkinson's disease in Denmark

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Small intestinal bacterial overgrowth recurrence after antibiotic therapy

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Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients

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Dietary herb extract Dai-Kenchu-To ameliorates constipation in parkinsonian patients (Parkinson's disease and multiple system atrophy)

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Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease

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Macrogol 3350/electrolyte improves constipation in Parkinson's disease and multiple system atrophy

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