期刊
OPHTHALMOLOGY AND THERAPY
卷 12, 期 5, 页码 2227-2240出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s40123-023-00730-z
关键词
Glaucoma; Therapy; Progression; Adherence; Persistence
Glaucoma is a progressive optic neuropathy characterized by retinal ganglion cell loss and visual field deterioration. While the exact cause of glaucoma is still unknown, elevated intraocular pressure has been identified as a modifiable risk factor. Treatment with eye drops to lower intraocular pressure has been proven effective in reducing the risk of disease progression. However, many patients with glaucoma struggle with adherence to medication, which is associated with poor treatment outcomes and increased healthcare costs.
Glaucoma is a group of progressive optic neuropathies characterized by loss of retinal ganglion cells and visual field deterioration. Despite the fact that the underlying pathophysiology of glaucoma remains unknown, elevated intraocular pressure (IOP) is a well-established risk factor, and the only factor that can be modified. Robust evidence from epidemiological studies and clinical trials has clearly demonstrated the benefits of IOP control in reducing the risk of glaucoma progression. IOP-lowering therapy by the means of eye drops remains a first-line treatment option. However, like other chronic and asymptomatic conditions, many patients with glaucoma have difficulties in maintaining high rates of adherence persistence to prescribed medications. On average, patients with chronic medical conditions take 30-70% of the prescribed medication doses, and on average 50% discontinue medications in the first months of therapy. The ophthalmic literature shows similarly low rates of adherence to treatment. Indeed, poor adherence is associated with disease progression and increased complication rates, as well as healthcare costs. The present review analyzes and discusses the causes of variability of the adherence to the prescribed drugs. The education of patients about glaucoma and the potential consequences of insufficient adherence and persistence seems fundamental to maximize the probability of treatment success and therefore prevent visual disability to avoid unnecessary healthcare costs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据