4.6 Article

Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Applied

In vitro anti-PRV activity of dihydromyricetin from Ampelopsis grossedentata

Wei Sun et al.

Summary: The study found that Dihydromyricetin (DMY) extracted from Ampelopsis grossedentata has anti-Pseudorabies virus (PRV) activity by interfering with the virus invasion into host cells and inhibiting pyroptosis, suggesting it may serve as a potential anti-PRV drug.

NATURAL PRODUCT RESEARCH (2022)

Review Pharmacology & Pharmacy

Physiological and pharmacological modulation of BAX

Adam Z. Spitz et al.

Summary: In this article, recent studies on the activation of BAX protein are discussed, providing structure-function insights and identifying regulatory surfaces that control BAX activation. The development of small molecule modulators is emphasized as a novel approach towards understanding and targeting BAX for therapeutic purposes.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Review Virology

A Review of Pseudorabies Virus Variants: Genomics, Vaccination, Transmission, and Zoonotic Potential

Zongyi Bo et al.

Summary: Research on PRV variants has made significant progress, but further exploration of its replication, pathogenicity, and transmission mechanisms is still needed in order to ultimately eradicate the virus in China.

VIRUSES-BASEL (2022)

Review Virology

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

Miroslava Sudomova et al.

Summary: This article presents the recent advances and mechanisms in utilizing flavonoids as natural drugs for the treatment of herpesvirus infections, with a focus on the neurological complications associated with these infections.

VIRUSES-BASEL (2022)

Article Virology

Pseudorabies Virus ICP0 Abolishes Tumor Necrosis Factor Alpha-Induced NF-kappa B Activation by Degrading P65

Xiangbo Zhang et al.

Summary: The study revealed that the PRV-encoded immediate early protein ICP0 inhibits the NF-kappa B signaling pathway, reduces the expression of inflammatory cytokines IL-6 and IL-8, and therefore enables escape from the host immune response.

VIRUSES-BASEL (2022)

Article Microbiology

Resveratrol Inhibits Pseudorabies Virus Replication by Targeting IE180 Protein

Xiangxiu Chen et al.

Summary: Resveratrol inhibits pseudorabies virus replication by targeting specific sites of the IE180 protein, providing important insights into its antiviral mechanism against herpes viruses.

FRONTIERS IN MICROBIOLOGY (2022)

Article Virology

Pseudorabies Virus Infection Results in a Broad Inhibition of Host Gene Transcription

Nicolas Romero et al.

Summary: The pseudorabies virus (PRV) inhibits host gene transcription and redirects cellular protein production towards viral proteins by recruiting essential host transcription factors in viral replication centers. This mechanism of PRV interferes with the production of host proteins involved in antiviral responses.

JOURNAL OF VIROLOGY (2022)

Review Virology

The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans

Qingyun Liu et al.

Summary: Pseudorabies virus (PRV) is a virus that can infect most mammals and causes economic losses in the pig industry. It can lead to severe symptoms and high mortality, and there has been an increasing number of human cases reported in China. This review provides an overview of the global prevalence and variation of PRV, as well as the vaccines and diagnostic methods used for control. While control programs have been implemented in many countries, PRV is still globally epizootic and an important pathogen for pigs.

VIRUSES-BASEL (2022)

Review Virology

Progress of Research into Novel Drugs and Potential Drug Targets against Porcine Pseudorabies Virus

Mo Zhou et al.

Summary: This review article provides an overview of recent research progress in drugs and drug targets against pseudorabies virus (PRV), and discusses the future research prospects of anti-PRV drugs.

VIRUSES-BASEL (2022)

Article Biochemical Research Methods

Antiviral effect of an extract from Kaempferia galanga L. rhizome in mice infected with pseudorabies virus

Xu Chen et al.

Summary: This study found that the extract from the rhizome of Kaempferia galanga L (Kge) exhibited potent anti-pseudorabies virus (PrV) activity and improved the survival rate of infected mice. Kge treatment also reduced virus titers and alleviated PrV-induced lesions. The anti-PrV activity of Kge may be attributed to its immune-regulating effects.

JOURNAL OF VIROLOGICAL METHODS (2022)

Article Microbiology

Myricetin inhibits pseudorabies virus infection through direct inactivation and activating host antiviral defense

Huaiyue Hu et al.

Summary: Myricetin has potent antiviral activity against pseudorabies virus, inhibiting viral adsorption, penetration, and replication in cells. It can also activate host antiviral defense mechanisms and improve the survival rate and reduce viral loads in a PRV-infected mouse model. Myricetin shows potential as a candidate for the development of new anti-herpesvirus drugs.

FRONTIERS IN MICROBIOLOGY (2022)

Review Pharmacology & Pharmacy

Flavonoids as Potential Antiviral Agents for Porcine Viruses

Xinwei Zhang et al.

Summary: Flavonoids are natural substances with phenolic structures that have antioxidant, anti-inflammatory, anticancer, and antiviral activities. This review summarizes the recent progress in understanding the antiviral mechanisms of flavonoids against porcine viruses, highlighting their potential for controlling porcine virus infection and developing pig feed additives.

PHARMACEUTICS (2022)

Review Biochemistry & Molecular Biology

Recent Research on Flavonoids and their Biomedical Applications

Kangmei Wen et al.

Summary: Flavonoids, a class of polyphenolic compounds with a basic structural unit of 2-phenylchromone, have wide potential applications in biomedicine. A review of literature on the medical use of flavonoids in the past decade has documented their pharmacological activities and mechanisms of action against various health disorders. The findings provide suggestions for further research on the biomedical applications of flavonoids.

CURRENT MEDICINAL CHEMISTRY (2021)

Letter Ophthalmology

Bilateral Necrotizing Retinitis following Encephalitis Caused by the Pseudorabies Virus Confirmed by Next-Generation Sequencing

Feng Hu et al.

Summary: This study reported a case of bilateral necrotizing retinitis following viral encephalitis caused by the pseudorabies virus. The patient was a 49-year-old male pig slaughterer. The findings emphasize the potential risk of pseudorabies virus causing retinitis among individuals with close contact to pigs.

OCULAR IMMUNOLOGY AND INFLAMMATION (2021)

Article Infectious Diseases

Latent pseudorabies virus infection in medulla oblongata from quarantined pigs

Jin-Jin Lu et al.

Summary: The study investigated latent infection with wild-type (wt) PRV and also infection due to the use of live attenuated vaccines on farms. Results showed that PRV DNA fragments were found in the brain tissues of pigs, indicating that live vaccines and wild-type viruses co-exist and may pose potential safety risks to the pig husbandry industry.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

Review Microbiology

The structural basis of herpesvirus entry

Sarah A. Connolly et al.

Summary: Herpesviruses are enveloped, double-stranded DNA viruses that establish lifelong infections and cause a variety of diseases. The entry into host cells involves the binding of the virus to specific receptors and the coordinated action of multiple viral entry glycoproteins. While the core fusion machinery is conserved among all herpesviruses, each species uses distinct receptors and receptor-binding glycoproteins.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Virology

Pseudorabies Virus Infection Triggers NF-κB Activation via the DNA Damage Response but Actively Inhibits NF-κB-Dependent Gene Expression

Nicolas Romero et al.

Summary: The NF-kappa B pathway plays a crucial role in coordinating innate immune responses during infections. PRV infection triggers NF-kappa B activation via an inside-out nucleus-to-cytoplasm signal initiated by the DNA damage response. The virus actively inhibits NF-kappa B-dependent gene expression, potentially to counteract antiviral consequences of the DDR-NF-kappa B signaling axis.

JOURNAL OF VIROLOGY (2021)

Review Chemistry, Medicinal

Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation

Huihui Li et al.

Summary: Herbs continue to be important sources of antiviral drugs, with alkaloids playing a key role in their pharmacological activities. This review summarizes recent research on herb-based antiviral treatments and the inflammatory responses initiated by alkaloids, providing insights into potential therapeutic strategies for viral infections. Further research is needed to develop alkaloidal compounds as effective antiviral agents and regulators of the anti-inflammatory response.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Veterinary Sciences

The antiviral activity of kaempferol against pseudorabies virus in mice

Lixia Li et al.

Summary: The results of this study indicate that kaempferol shows anti-Pseudorabies virus activity in mice, improving survival rates, inhibiting virus replication, alleviating pathogenic changes in organs, and affecting viral gene transcription.

BMC VETERINARY RESEARCH (2021)

Article Agriculture, Multidisciplinary

Kaempferol inhibits Pseudorabies virus replication in vitro through regulation of MAPKs and NF-κB signaling pathways

Chen Xu et al.

Summary: The study demonstrates that kaempferol is a potential drug candidate for controlling Pseudorabies virus infection by inhibiting viral replication, reducing cell death, and modulating signaling pathways involved in PRV infection.

JOURNAL OF INTEGRATIVE AGRICULTURE (2021)

Article Multidisciplinary Sciences

Cytokine storms and pyroptosis are primarily responsible for the rapid death of mice infected with pseudorabies virus

Wei Sun et al.

Summary: This study investigated the pathogenesis induced by PRV in a mouse model, revealing that the cytokine storms caused by PRV were related to histopathological changes and activated the pyroptosis pathway. These findings provide insights into the molecular basis of PRV pathogenesis.

ROYAL SOCIETY OPEN SCIENCE (2021)

Article Veterinary Sciences

Establishment of inflammatory model induced by Pseudorabies virus infection in mice

Chun-Zhi Ren et al.

Summary: The study established an inflammatory model induced by PRV infection in mice, with 10(2) TCID50 PRV considered as the optimal concentration for model establishment. PRV infection caused increased immune organ indices, ROS and NO levels, inflammatory mediators, and oxidative stress.

JOURNAL OF VETERINARY SCIENCE (2021)

Article Infectious Diseases

Natural infection of a variant pseudorabies virus leads to bovine death in China

Zilong Cheng et al.

TRANSBOUNDARY AND EMERGING DISEASES (2020)

Letter Infectious Diseases

Novel Chinese pseudorabies virus variants undergo extensive recombination and rapid interspecies transmission

Jinbiao Liu et al.

TRANSBOUNDARY AND EMERGING DISEASES (2020)

Review Nutrition & Dietetics

Antiviral Properties of Flavonoids and Delivery Strategies

Paolino Ninfali et al.

NUTRIENTS (2020)

Article Infectious Diseases

Anti-HSV-1 effect of dihydromyricetin from Ampelopsis grossedentata via the TLR9-dependent anti-inflammatory pathway

Hai-yun Zhou et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

Article Immunology

Interspecies Transmission, Genetic Diversity, and Evolutionary Dynamics of Pseudorabies Virus

Wanting He et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

Editorial Material Immunology

Pseudorabies virus: a neglected zoonotic pathogen in humans?

Gary Wong et al.

EMERGING MICROBES & INFECTIONS (2019)

Article Veterinary Sciences

Vaccine resistant pseudorabies virus causes mink infection in China

Gui-sheng Wang et al.

BMC VETERINARY RESEARCH (2018)

Review Pharmacology & Pharmacy

Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

Jingyao Zhang et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-B signalling in human melanoma cells

Ding-Zhou Zhou et al.

FREE RADICAL RESEARCH (2017)

Review Cell Biology

Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection

Megan H. Orzalli et al.

TRENDS IN CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation

Hector Flores-Romero et al.

SCIENTIFIC REPORTS (2017)

Article Virology

gD-Independent Superinfection Exclusion of Alphaherpesviruses

A. Criddle et al.

JOURNAL OF VIROLOGY (2016)

Article Cell Biology

Dihydromyricetin suppresses TNF-α-induced NF-κB activation and target gene expression

Nina Tang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2016)

Review Pharmacology & Pharmacy

Bioactive natural products with anti-herpes simplex virus properties

Sherif T. S. Hassan et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)

Review Chemistry, Medicinal

Anti-herpesvirus agents: a patent and literature review (2003 to present)

Marcin Skorenski et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2014)

Review Biochemistry & Molecular Biology

Potential of protein kinase inhibitors for treating herpesvirus-associated disease

Renfeng Li et al.

TRENDS IN MICROBIOLOGY (2013)

Article Immunology

Pseudorabies Virus Variant in Bartha-K61-Vaccinated Pigs, China, 2012

Tong-Qing An et al.

EMERGING INFECTIOUS DISEASES (2013)

Article Biochemistry & Molecular Biology

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

G. Dewson et al.

CELL DEATH AND DIFFERENTIATION (2012)

Review Biochemistry & Molecular Biology

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

L. Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2012)

Article Cell Biology

Herpes Simplex Viruses: Mechanisms of DNA Replication

Sandra K. Weller et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Article Cell Biology

BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells

Rebecca J. Boohaker et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Review Biochemistry & Molecular Biology

Replication and Recombination of Herpes Simplex Virus DNA

Isabella Muylaert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Pseudorabies virus US3-mediated inhibition of apoptosis does not affect infectious virus production

Matthias J. Deruelle et al.

JOURNAL OF GENERAL VIROLOGY (2010)

Review Neurosciences

A Common Neuronal Response to Alphaherpesvirus Infection

Moriah L. Szpara et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2010)

Review Cell Biology

Mitochondria and cell death: outer membrane permeabilization and beyond

Stephen W. G. Tait et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

NF-κB signaling modulation by EBV and KSHV

Deilson Elgui de Oliveira et al.

TRENDS IN MICROBIOLOGY (2010)

Article Biotechnology & Applied Microbiology

Whole-genome analysis of pseudorabies virus gene expression by real-time quantitative RT-PCR assay

Dora Tombacz et al.

BMC GENOMICS (2009)

Article Cell Biology

The Nuclear Factor NF-κB Pathway in Inflammation

Toby Lawrence

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

Review Biochemistry & Molecular Biology

The alpha-herpesviruses: molecular pathfinders in nervous system circuits

Mats I. Ekstrand et al.

TRENDS IN MOLECULAR MEDICINE (2008)

Article Pharmacology & Pharmacy

Extracts and molecules from medicinal plants against herpes simplex viruses

MTH Khan et al.

ANTIVIRAL RESEARCH (2005)

Review Microbiology

Molecular biololgy of pseudorabies virus: Impact on neurovirology and veterinary medicine

LE Pomeranz et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2005)