☆ 4.7 Article

Gel Formulations with an Echinocandin for Cutaneous Candidiasis: The Influence of Azone and Transcutol on Biopharmaceutical Features

GELS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

A skin pharmacokinetics study of permeation enhancers: The root cause of dynamic enhancement effect on in vivo drug permeation

Jiuheng Ruan et al.

Summary: Skin pharmacokinetics (SPK) can explain the different effects of permeation enhancers on drug permeation at the kinetic level. SPK of permeation enhancers can be classified into lateral elimination and longitudinal elimination, and evaluated using the diffusion ratio (DRSC-EP). The linear relationship between parameters such as ke-enhancer and Delta Cmax-drug, MRTenhancer and Delta Tmax-drug, and AUCt-enhancer and Delta AUCt-drug suggests that SPK precisely controls drug permeation in vivo.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2023)

添加到收藏夹

Article Infectious Diseases

Antifungal activity and potential mechanism of action of caspofungin in combination with ribavirin against Candida albicans

Yuting Wang et al.

Summary: The number of invasive fungal infections has increased significantly, leading to high morbidity and mortality in immunocompromised patients. Caspofungin (CAS) resistance is a growing concern, limiting the treatment options for severe invasive Candida albicans infections. This study investigated the activity of CAS in combination with ribavirin (RBV) against C. albicans, and found that the combination had synergistic effects in inhibiting biofilm formation and reducing tissue damage. The findings provide insights into drug resistance and suggest potential applications for RBV in the treatment of C. albicans infections.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Contemporary applications of thermogelling PEO-PPO-PEO triblock copolymers

Kwadwo Mfoafo et al.

Summary: Poloxamers, also known as Pluronic(R), are amphiphilic polymers with thermo-responsive properties. They have been widely used in the pharmaceutical field for prolonging drug release, improving solubility, enhancing stability, and improving bioavailability. Their unique thermogelling property has also led to biomedical applications.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Assessment of Caspofungin use at a Tertiary Teaching Hospital and compliance with IDSA guidelines and FDA labelings

Abrar F. Alshehri et al.

Summary: This study evaluated the utilization pattern of Caspofungin in an academic tertiary care hospital in Riyadh, Saudi Arabia. The findings revealed a high rate of inappropriate use of Caspofungin.

SAUDI PHARMACEUTICAL JOURNAL (2022)

添加到收藏夹

Article Chemistry, Medicinal

Enhanced Transdermal Delivery of Pranoprofen Using a Thermo-Reversible Hydrogel Loaded with Lipid Nanocarriers for the Treatment of Local Inflammation

Maria Rincon et al.

Summary: A biocompatible topical thermo-reversible hydrogel containing PF-loaded NLCs was studied as a strategy for the topical treatment of skin inflammatory diseases. The hydrogel exhibited a heterogeneous structure and released the drug in vitro, while retaining a high amount of drug in human skin. It showed no cytotoxicity and effectively reduced inflammation.

PHARMACEUTICALS (2022)

添加到收藏夹

Article Materials Science, Multidisciplinary

First electrochemical study of a potent antifungal drug caspofungin: Application to its enhanced voltammetric sensing based on the performance of boron-doped diamond electrode in CTAB-mediated measurements

Hoshyar Saadi Ali et al.

Summary: This study presents the first electrochemical investigation of caspofungin using a pretreated boron-doped diamond electrode. By optimizing the experimental conditions, the sensitivity of the voltammetric measurements was improved, allowing for successful determination of caspofungin concentration in commercial dosage formulations.

DIAMOND AND RELATED MATERIALS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

Neha Raina et al.

Summary: This article reviews the application of hydrogels in the biomedical field and discusses the functional polymeric materials used for hydrogel fabrication and evaluation methods. The findings of various studies in different fields are summarized, and the application of hydrogels in drug delivery, tissue engineering, and other areas is discussed, as well as their potential and possibilities for improvement in the biomedical sector.

PHARMACEUTICS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies

Roya Mohammadi-Meyabadi et al.

Summary: The study aimed to evaluate the solubility of baricitinib in Transcutol and determine the drug recovery using in vitro techniques. Results showed that Transcutol enhanced the drug solubility and allowed baricitinib to penetrate different human tissues. This suggests that Transcutol may be a suitable solvent for further development of topical formulations.

PHARMACEUTICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae

Maytham Hussein et al.

Summary: Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that causes nosocomial infections. The combination of polymyxin B and the antifungal caspofungin exhibits marked synergistic antibacterial killing activity against K. pneumoniae. Moreover, the combination inhibits bacterial virulence pathways and multidrug efflux mechanisms.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

添加到收藏夹

Article Polymer Science

Comparative Study of Donepezil-Loaded Formulations for the Treatment of Alzheimer's Disease by Nasal Administration

Lupe Carolina Espinoza et al.

Summary: This study aimed to develop a new method of drug delivery for Alzheimer's disease through nasal administration. Different gels were prepared and characterized, and the results showed that pluronic gels had higher release rate and permeation, which could improve the bioavailability of donepezil.

GELS (2022)

添加到收藏夹

Article Medicine, General & Internal

Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity

Trinidad Montero-Vilchez et al.

Summary: This study compared skin barrier function between healthy skin, psoriatic skin, and atopic dermatitis skin, finding that TEWL was higher at psoriatic and AD lesions, while SCH was lower. Specific TEWL and temperature values may help clinicians determine disease severity and treatment needs.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Review Microbiology

Candida albicans-The Virulence Factors and Clinical Manifestations of Infection

Jasminka Talapko et al.

Summary: Candida albicans is a common commensal fungus in the human body, which can cause various infections when the balance with the host immune system is disrupted. Factors such as dysbiosis of microbiota, immune dysfunction, and mucosal barrier damage contribute to the transition of C. albicans from a normal flora to a pathogenic state. The presence of C. albicans in the bloodstream can lead to invasive infections.

JOURNAL OF FUNGI (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation

Salima El Moussaoui et al.

Summary: This study developed two formulations, a hydrogel and a nanostructured system, containing ketorolac tromethamine for local therapy against inflammation resulting from surgical excision of Condyloma acuminata. The nanoparticles exhibited significantly higher anti-inflammatory efficacy compared to the chitosan gel, making them promising candidates for local anti-inflammatory therapy with potential clinical application.

PHARMACEUTICS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Development of a Topical Amphotericin B and Bursera graveolens Essential Oil-Loaded Gel for the Treatment of Dermal Candidiasis

Lupe Carolina Espinoza et al.

Summary: The study aimed to incorporate Bursera graveolens essential oil into an Amphotericin B topical gel to promote drug diffusion for the treatment of cutaneous candidiasis. Results showed that the gel exhibited good characteristics for topical administration and had higher drug retention within the skin, with lower Minimum Inhibitory Concentration compared to a formulation without essential oil.

PHARMACEUTICALS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

The Implications of Regulatory Framework for Topical Semisolid Drug Products: From Critical Quality and Performance Attributes towards Establishing Bioequivalence

Tanja Ilic et al.

Summary: Topical semisolid drug formulations face unique obstacles to the development of generics due to complex interdependent relationships affecting their microstructure. Regulatory agencies have aimed to advance guidelines for topical generics, but industry and academia stakeholders believe that current efforts are far from flawless.

PHARMACEUTICS (2021)

添加到收藏夹

Article Polymer Science

New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis

Noelia Perez-Gonzalez et al.

Summary: The study developed and characterized three hydrogels containing chitosan, Poloxamer 407, and a combination of both with 2% caspofungin for the treatment of VVC. The formulations showed promising potential for treating VVC, with physically, mechanically, and morphologically characterized properties.

GELS (2021)

添加到收藏夹

Article Polymer Science

Topical Mucoadhesive Alginate-Based Hydrogel Loading Ketorolac for Pain Management after Pharmacotherapy, Ablation, or Surgical Removal in Condyloma Acuminata

Salima El Moussaoui et al.

Summary: The study developed a biocompatible topical hydrogel containing ketorolac tromethamine for managing painful inflammatory processes caused by the removal of anogenital condylomas. The hydrogel showed adequate characteristics for topical formulation and displayed good local tolerance on human skin and vaginal mucosa. With 53% anti-inflammatory activity, the ketorolac hydrogel is considered stable and suitable for treating inflammatory processes associated with anogenital warts removal.

GELS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Topical Amphotericin B Semisolid Dosage Form for Cutaneous Leishmaniasis: Physicochemical Characterization, Ex Vivo Skin Permeation and Biological Activity

Diana Berenguer et al.

PHARMACEUTICS (2020)

添加到收藏夹

Review Engineering, Biomedical

Poloxamer: A versatile tri-block copolymer for biomedical applications

Payam Zarrintaj et al.

ACTA BIOMATERIALIA (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Cornelia Vasile et al.

MOLECULES (2020)

添加到收藏夹

Review Infectious Diseases

Review on Current Status of Echinocandins Use

Martyna Mroczynska et al.

ANTIBIOTICS-BASEL (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications

Carmen P. Jimenez-Gomez et al.

MOLECULES (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Transcutol P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery

Giulia Pitzanti et al.

PHARMACEUTICS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications

Karim A. Soliman et al.

DRUG DISCOVERY TODAY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Self-Assembly of Partially Alkylated Dextran-graft-poly[(2-dimethylamino)ethyl methacrylate] Copolymer Facilitating Hydrophobic/Hydrophilic Drug Delivery and Improving Conetwork Hydrogel Properties

Arvind K. Singh Chandel et al.

BIOMACROMOLECULES (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Skin Penetration and Permeation Properties of Transcutol (R) Neat or Diluted Mixtures

David W. Osborne et al.

AAPS PHARMSCITECH (2018)

添加到收藏夹

Review Polymer Science

Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

Pasquale Sacco et al.

GELS (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment

Roser Sanz et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin

Paulina Carvajal-Vidal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Echinocandins in antifungal pharmacotherapy

Akash Patil et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2017)

添加到收藏夹

Review Medicine, Research & Experimental

Recent advances in delivery of antifungal agents for therapeutic management of candidiasis

Bhakti Sawant et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure-Activity Relationship

Priyanka Sahariah et al.

BIOMACROMOLECULES (2017)

添加到收藏夹

Article Chemistry, Medicinal

Enhanced topical delivery of tacrolimus by a carbomer hydrogel formulation with transcutol P

Sang Gon Lee et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2016)

添加到收藏夹

Article Polymer Science

Enhanced Transdermal Permeability via Constructing the Porous Structure of Poloxamer-Based Hydrogel

Wen-Yi Wang et al.

POLYMERS (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Mucoadhesive Chitosan Derivatives as Novel Drug Carriers

Mohammad Ariful Islam et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

添加到收藏夹

Article Infectious Diseases

Pharmacokinetics, efficacy, and safety of caspofungin in Japanese pediatric patients with invasive candidiasis and invasive aspergillosis

Masaaki Mori et al.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Developing cutaneous applications of paromomycin entrapped in stimuli-sensitive block copolymer nanogel dispersions

Alba Pujol Brugues et al.

NANOMEDICINE (2015)

添加到收藏夹

Article Dermatology

An in vitro Skin Penetration Model for Compromised Skin: Estimating Penetration of Polyethylene Glycol [14C]-PEG-7 Phosphate

Swatee Dey et al.

SKIN PHARMACOLOGY AND PHYSIOLOGY (2015)

添加到收藏夹

Article Dermatology

Semisolid formulations containing cetirizine: human skin permeation and topical antihistaminic evaluation in a rabbit model

Claudia Ciurlizza et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2014)

添加到收藏夹

Review Food Science & Technology

A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient

Dexter W. Sullivan et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

添加到收藏夹

Review Pharmacology & Pharmacy

Novel chemical permeation enhancers for transdermal drug delivery

Yang Chen et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

添加到收藏夹

Article Immunology

Drug-Resistant Candida glabrata Infection in Cancer Patients

Dimitrios Farmakiotis et al.

EMERGING INFECTIOUS DISEASES (2014)

添加到收藏夹

Review Pharmacology & Pharmacy

Skin penetration enhancers

Majella E. Lane

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

添加到收藏夹

Review Pharmacology & Pharmacy

Penetration enhancers

Adrian C. Williams et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

添加到收藏夹

Article Biophysics

Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation

Filipe E. Antunes et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2011)

添加到收藏夹

Article Chemistry, Medicinal

Rheological Evaluation of Petroleum Jelly as a Base Material in Ointment and Cream Formulations: Steady Shear Flow Behavior

Eun-Kyoung Park et al.

ARCHIVES OF PHARMACAL RESEARCH (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Enhancement of transdermal drug delivery via synergistic action of chemicals

Pankaj Karande et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Insights into the mode of action of chitosan as an antibacterial compound

Dina Raafat et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)

添加到收藏夹

Review Infectious Diseases

Caspofungin: the first representative of a new antifungal class

V Letscher-Bru et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2003)

添加到收藏夹

Article Chemistry, Physical

Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution

PR Desai et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.