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Progress in Surface Modification of Titanium Implants by Hydrogel Coatings

GELS (2023)

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Article Biochemistry & Molecular Biology

Boosting bone cell growth using nanofibrous carboxymethylated cellulose and chitosan on titanium dioxide nanotube array with dual surface charges as a novel multifunctional bioimplant surface

Seyed Yahya Rahnamaee et al.

Summary: The study investigates the use of multifunctional polysaccharides as implant coatings. Scanning electron microscopy revealed nanofibrous morphology for carboxymethyl cellulose and carboxymethyl chitosan nanofibers, similar to extracellular matrix structures. Both coatings showed increased roughness compared to the titanium nanotube surface, and carboxymethyl chitosan nanofibers with a positively charged surface exhibited improved cell proliferation rate. In antibacterial experiments, carboxymethyl cellulose and carboxymethyl chitosan inhibited bacterial colony formation by 80% and 73% respectively. The modified polysaccharide coatings increased osteoblast cell survival and inhibited bacterial biofilm formation due to their surface charge and bioinspired properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Engineering, Biomedical

Peptide GL13K releasing hydrogel functionalized micro/nanostructured titanium enhances its osteogenic and antibacterial activity

Xiaojing Zhang et al.

Summary: In this study, a micro/nanostructured titanium surface was created by dual-acid treatment and anodic oxidation, and then coated with GelMA hydrogel loaded with GL13K to develop anti-bacterial titanium implants. The results showed that the modified titanium surface had good biocompatibility, promoted osteoblast differentiation, and prevented the growth of gram-positive and gram-negative bacteria by the release of GL13K.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2023)

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Review Pharmacology & Pharmacy

Recent Advancements in Metallic Drug-Eluting Implants

Sadeq Alshimaysawee et al.

Summary: In the past decade, metallic drug-eluting implants have gained significance for controlled drug release in orthopedic and dental applications, particularly in preventing infection. Recent studies have shown that these implants, loaded with drugs, can achieve sustained and controlled drug release, leading to desirable therapeutic effects. Various types of drug-eluting implants, containing drugs such as anti-inflammatory agents, antibiotics, growth factors, and anti-resorptive drugs, have been developed to meet specific needs.

PHARMACEUTICS (2023)

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Article Microbiology

Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery

Irene E. E. Sille et al.

Summary: Concerns about joint implant infections have led to the development of a novel coating consisting of polyacrylamide hydrogel loaded with antibiotics and silver nanoparticles. This coating successfully inhibits bacterial adhesion and biofilm formation, and exhibits excellent antibacterial efficacy and cytocompatibility.

PATHOGENS (2023)

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Article Nanoscience & Nanotechnology

Fabrication of a New Hyaluronic Acid/Gelatin Nanocomposite Hydrogel Coating on Titanium-Based Implants for Treating Biofilm Infection and Excessive Inflammatory Response

Yao Ding et al.

Summary: In this study, ZIF-90-Bi-CeO2 nanoparticles were incorporated into a Schiff-base chemically crosslinked hydrogel to achieve antibacterial and anti-biofilm functions. The modified Ti substrate showed a dual-enzyme catalytic activity and regulated oxidative stress and inflammatory response, promoting osseointegration. This provides a novel strategy for the treatment of biofilm infection and excessive inflammation.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Biochemistry & Molecular Biology

Multifunctional antibacterial chitosan-based hydrogel coatings on Ti6Al4V biomaterial for biomedical implant applications

Jon Andrade del Olmo et al.

Summary: In the biomedical community, there has been a focus on developing antibacterial coatings to prevent implant-associated infections. Traditional mono-functional antibacterial strategies have not been sufficient for long-term success. Researchers have recently turned their attention to novel bifunctional or multifunctional antibacterial coatings that combine multiple antibacterial mechanisms. In this study, chitosan-based hydrogel coatings with genipin and polyethylene glycol crosslinking agents were created on a Ti6Al4V surface. These hydrogel coatings demonstrated excellent biocompatibility, as well as the ability to promote cell proliferation and differentiation. Additionally, they showed outstanding bacteria-repelling and contact killing ability. The controlled release of drugs could further enhance their multifunctional antibacterial properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Pharmacology & Pharmacy

Titanium surface polyethylene glycol hydrogel and gentamicin-loaded cross-linked starch microspheres release system for anti-infective drugs

Yunfeng Wu et al.

Summary: In this study, a hydrogel drug-controlled release system loaded with gentamicin on a titanium surface was successfully designed and constructed, and its antibacterial properties and biocompatibility were evaluated. The Ti-GEN-Cst-PLGA system effectively inhibited the growth of bacteria and promoted wound healing, making it a potential treatment for orthopaedic endophytes.

JOURNAL OF DRUG TARGETING (2023)

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Article Pharmacology & Pharmacy

Novel bilayer coating on gentamicin-loaded titanium nanotube for orthopedic implants applications

Hossein Shaygani et al.

Summary: This study developed a drug-loaded surface-modified titanium nanotube (TNT) implant with different surface coatings and investigated their effect on drug release, antimicrobial activity, and cell proliferation. The results showed that coatings prolonged drug release, and chitosan coating had better antimicrobial activity and cell viability. Both cell viability assay and molecular dynamics simulations indicated that chitosan had the highest adsorption energy. Therefore, the proposed bilayer chitosan-coated drug-loaded TNT implant with chitosan and sodium alginate coating has potential for orthopedic applications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Multidisciplinary Sciences

Electrochemical and biological characterization of Ti-Nb-Zr-Si alloy for orthopedic applications

Aydin Bordbar-Khiabani et al.

Summary: The presence of hydrogen peroxide affects the corrosion resistance of titanium biomaterials, while the synergistic action of hydrogen peroxide, albumin, and lactate under severe inflammatory conditions decreases the corrosion resistance. The TNZS alloy, with the addition of silicide phases, demonstrates superior corrosion resistance in all conditions and favorable biocompatibility in cell culture investigations, suggesting its potential as a competitive biomaterial for orthopedic applications.

SCIENTIFIC REPORTS (2023)

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Article Engineering, Biomedical

A Multifunction Hydrogel-Coating Engineered Implant for Rescuing Biofilm Infection and Boosting Osseointegration by Macrophage-Related Immunomodulation

Yao Ding et al.

Summary: In this study, a functionalization strategy for doping Tannic acid-d-tyrosine nanoparticles with photothermal profile into the hydrogel coating composed of konjac gum and gelatin on the surface of titanium (Ti) substrate is accurately constructed. The modified Ti implant significantly eliminates the residual bacteria, relieves inflammation, mediates macrophage polarization, and accelerates osseointegration.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Engineering, Biomedical

Semaphorin 3A delivered by a rapidly polymerizing click hydrogel overcomes impaired implant osseointegration in a rat type 2 diabetes model

Jingyao Deng et al.

Summary: The study demonstrates that the delivery of semaphorin 3A (sema3A) enhances osseointegration in T2DM rats with impaired bone quality, improving osteoblast differentiation and increasing bone contact with implants. This suggests the potential of sema3A as a treatment option for osseointegration issues in T2DM patients.

ACTA BIOMATERIALIA (2023)

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Article Biotechnology & Applied Microbiology

Functional chitosan gel coating enhances antimicrobial properties and osteogenesis of titanium alloy under persistent chronic inflammation

Ti Zhang et al.

Summary: Titanium alloy is widely used for surgical bone implants, but the risk of failure in interfacial integration still exists due to chronic inflammation and bacterial infections caused by titanium implants. In this study, chitosan gels crosslinked with glutaraldehyde were loaded with silver nanoparticles and catalase nanocapsules to achieve functional coating on the surface of titanium alloy steel plates. The functional coating reduced inflammation and enhanced osteogenesis, while inhibiting the growth of bacteria. This work provides a general approach for functional coating of titanium alloy implants and other scaffolding materials.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Review Polymer Science

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Siriporn Taokaew et al.

Summary: This review summarizes the advanced functions and properties of chitosan-based hydrogels in pharmaceutical and biomedical applications, including drug delivery, tissue engineering, disease treatments, and biosensors. It also prospects the current challenges and future development direction of chitosan-based hydrogels.

GELS (2023)

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Review Polymer Science

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Huangqin Chen et al.

Summary: Scientists have been researching the combination of mesoporous materials and hydrogels to improve drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. Mesoporous materials have shown significant potential in enhancing the properties and effectiveness of hydrogels in these applications. The paper provides an overview of the classification and preparation methods of mesoporous material-loaded composite hydrogels, as well as highlighting the latest research progress and future research directions.

GELS (2023)

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Article Materials Science, Multidisciplinary

Biocompatibility of Ti-6Al-4V titanium alloy implants with laser microgrooved surfaces

Qingchun Zheng et al.

Summary: In this paper, laser processing technology was used to create microgrooves on the surface of Ti-6Al-4V titanium alloy implants. The effects of these microgrooves on cell behavior were studied, and it was found that they promoted cell proliferation and differentiation by increasing wettability and surface roughness.

MATERIALS TECHNOLOGY (2022)

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Article Engineering, Biomedical

An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties

Weizhen Chen et al.

Summary: This study focuses on the surface modification of metal implants using pitavastatin to enhance bone defect healing through the synergistic osteogenesis-angiogenesis regulation. The researchers constructed multilayer films with osteogenic and angiogenic properties on pure titanium substrates, and found that locally applied pitavastatin dramatically enhanced the osteogenic potential of mesenchymal stem cells (MSCs) and the angiogenic potential of endothelial cells (ECs). Furthermore, the pitavastatin-loaded films were able to regulate the paracrine signaling between MSCs and ECs, indirectly increasing the angiogenic potential of MSCs and the osteogenic potential of ECs. Subcutaneous and femur implantation experiments confirmed that locally released pitavastatin promoted endogenous stem cells and ECs to the implant-bone interface, facilitating coupled osteogenesis and angiogenesis, and enhancing peri-implant osseointegration.

BIOMATERIALS (2022)

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Article Dentistry, Oral Surgery & Medicine

Electrophoretic deposition of novel semi-permeable coatings on 3D-printed Ti-Nb alloy meshes for guided alveolar bone regeneration

Danlei Zhao et al.

Summary: In this study, multi-functional coatings with 3D-printed porous titanium-niobium (Ti-Nb) alloy meshes were fabricated for guided bone regeneration (GBR). The coatings were able to maintain space, prevent fibroblast ingrowth, and inhibit bacterial colonization. The experimental results demonstrated that the coatings had antibacterial effects, biocompatibility, and the ability to prevent fibroblast infiltration while allowing nutrient penetration.

DENTAL MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae

Sabine Stoetzel et al.

Summary: In this preclinical study, the effects of different bioactive coatings on titanium implants were evaluated using histological analysis and cellular balance assessment. The results showed that the chitosan/gelatin-coated titanium implants exhibited improved bone matrix quality and cellular balance compared to the chitosan/hyaluronic acid-coated and native implants.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Dentistry, Oral Surgery & Medicine

Titanium Nitride Coated Implant Abutments: From Technical Aspects And Soft tissue Biocompatibility to Clinical Applications. A Literature Review

Rafael del Castillo et al.

Summary: The application of titanium nitride hard thin film coatings on titanium alloy implant abutments improves clinical longevity, enhances mechanical properties and biocompatibility, and enhances aesthetic outcomes. So far, available research has shown promising results in terms of mechanical, biological, and esthetic outcomes.

JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY (2022)

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Article Engineering, Biomedical

Engineering Multifunctional Hydrogel-Integrated 3D Printed Bioactive Prosthetic Interfaces for Osteoporotic Osseointegration

Zuhao Li et al.

Summary: In order to address the high risk issues in joint replacement surgery, a novel class of multifunctional hydrogel-integrated 3D printed bioactive prosthetic interfaces has been developed, which can promote osseointegration and inhibit infection in osteoporotic environment.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Materials Science, Biomaterials

Regulation of Macrophage Polarization by Mineralized Collagen Coating to Accelerate the Osteogenic Differentiation of Mesenchymal Stem Cells

Jiaqi Shao et al.

Summary: This study demonstrates that the phenotype of macrophages can be regulated by decorating the implant surface with mineralized collagen coating, which accelerates osteogenesis. This helps to create an osteoimmune microenvironment and promotes the osteogenic differentiation of mesenchymal stem cells.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Physical

One-step electrodeposition of Janus chitosan coating for metallic implants with anti-corrosion properties

Yinghao Jian et al.

Summary: A hydrophilic-hydrophobic Janus chitosan coating was easily fabricated through one-step electrodeposition in an HCl/ethanol solvent. The compact structure on one face and porous structure on the other face of the coating give it asymmetric wettability. The concentration of ethanol significantly affects the structure and wettability of the coating, and the study also investigates the corrosion resistance of the coating on metallic implants.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

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Article Engineering, Biomedical

Electrochemical deposition of lithium coating on titanium implant with enhanced early stage osseointegration

Tingben Huang et al.

Summary: Studies have shown that incorporating lithium into implant surfaces through electrochemical deposition can enhance early osseointegration. This study investigated the effects of lithium-incorporated surfaces on adhesion, proliferation, and osseointegration in vivo. The results demonstrated that the lithium-incorporated surfaces promoted adhesion and proliferation of BMSCs in the early stage. In addition, the micro-CT and hard tissue sectioning analysis revealed that the lithium-incorporated implants had significantly higher bone volume/total volume, bone-implant contact, and Tb.Th values compared to the control group at 4 weeks, indicating improved osseointegration.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2022)

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Article Materials Science, Multidisciplinary

Design of a new Ti-Mo-Cu alloy with excellent mechanical and antibacterial properties as implant materials

Yixiang Yuan et al.

Summary: This study successfully developed Ti-Mo-Cu alloys with excellent antibacterial properties, composed mainly of beta-Ti, alpha-Ti, and Ti2Cu, exhibiting strong mechanical properties and high antibacterial rates against E. coli and S. aureus.

MATERIALS LETTERS (2022)

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Article Cell & Tissue Engineering

Tailoring Copper-Doped Bioactive Glass/Chitosan Coatings with Angiogenic and Antibacterial Properties

Jing Han et al.

Summary: This study introduces a bottom-up coating deposition method based on nanoparticle assembly to allow for local release of copper ions from implant surfaces. The method improves endothelial cell migration and reduces bacterial growth, and can be used to incorporate other therapeutic agents onto implant surfaces.

TISSUE ENGINEERING PART C-METHODS (2022)

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Article Engineering, Biomedical

Hybrid fabrication of photo-clickable vascular hydrogels with additive manufactured titanium implants for enhanced osseointegration and vascularized bone formation

Jun Li et al.

Summary: Bone regeneration in critical-sized bone defects, fractures or joint replacements is a significant clinical challenge. This study developed an in vitro vascularized bone implant by combining cell-laden hydrogels with porous titanium alloys, which can achieve rapid vascularization and long-term biological fixation in large bone defects.

BIOFABRICATION (2022)

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Article Polymer Science

Hydrogel-based therapeutic coatings for dental implants

Seyed Ebrahim Alavi et al.

Summary: Dental implants are commonly used to strengthen dental prostheses and replace normal teeth function. Hydrogel-based coatings can enhance the biocompatibility, osseointegration, and antimicrobial properties of dental implants, improving their efficacy through the incorporation of various compounds.

EUROPEAN POLYMER JOURNAL (2022)

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Article Polymer Science

Improved mechanical and tribological properties of PAAm/PVA hydrogel-Ti6Al4V alloy configuration for cartilage repair

Yan Shi et al.

Summary: The study demonstrates that incorporating PAAm into PVA hydrogel can improve its mechanical properties, but a higher mass ratio of PAAm:PVA leads to a degradation in mechanical properties. PAAm/PVA hydrogel with a PAAm:PVA ratio of 1:1 exhibits higher interfacial toughness, while PAAm/PVA hydrogel with a PAAm:PVA ratio of 1:3 shows a lower friction coefficient. Additionally, the load carrying capacity of PAAm/PVA hydrogel is significantly improved by the support of Ti6Al4V alloy substrate.

JOURNAL OF POLYMER RESEARCH (2022)

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Article Engineering, Biomedical

Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis

Yuyu Zhao et al.

Summary: Researchers developed a type I collagen decorated nanoporous network on titanium surfaces to regulate the osseointegration process of implants. The decorated network could modulate inflammation and angiogenesis, as well as promote osteogenesis, resulting in favorable osseointegration.

BIOMATERIALS (2022)

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Article Engineering, Biomedical

ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation

Xuan Li et al.

Summary: In this study, a novel functionalized titanium implant with a hydrogel coating loaded with Tβ4 was designed and evaluated. The coating exhibited strong adhesion to the titanium substrate, and it could release Tβ4 in response to the immune reaction of bone healing, promoting vascularization and osteointegration of bone defects.

BIOMATERIALS (2022)

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Article Polymer Science

Antibacterial Activity and Biocompatibility with the Concentration of Ginger Fraction in Biodegradable Gelatin Methacryloyl (GelMA) Hydrogel Coating for Medical Implants

Seo-young Kim et al.

Summary: Gingerols and shogaols derived from ginger exhibit excellent antibacterial properties but potential toxicity. This study aimed to improve the biofunctionality and biocompatibility of ginger in dental applications. Ginger was loaded in a GelMA hydrogel at different concentrations to increase its coating on titanium screws and control release. The ginger hydrogel showed effective inhibition against oral bacteria, with slow release of ginger compounds. Although bone regeneration was slightly reduced at higher ginger concentrations, the hydrogel and pre-calcification coating promoted osteosis formation. The GH-TNC coating on titanium implants demonstrated biosafety and superior biofunctionality.

POLYMERS (2022)

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Article Pharmacology & Pharmacy

Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties

Soada Asadi et al.

Summary: This study synthesized TiO2-NTs and evaluated the effects of different electrolyte conditions on their dimensions, finding that TiO2-NTs have high loading efficiency. The sustained release of drugs was achieved by coating TiO2-NTs with chitosan layers, and the impact of chitosan layer count on release was demonstrated. Antimicrobial activity evaluation showed good inhibitory effects against two endodontic species.

PHARMACEUTICS (2022)

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Review Biotechnology & Applied Microbiology

Role of chitosan in titanium coatings. trends and new generations of coatings

Nansi Lopez-Valverde et al.

Summary: This study provides an overview of the current concepts and theories of osseointegration and current titanium dental implant surfaces and coatings, with a special focus on the in vivo investigation of chitosan-coated implants and a current perspective on the future of titanium dental implant coatings.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

Using a degradable three-layer sandwich-type coating to prevent titanium implant infection with the combined efficient bactericidal ability and fast immune remodeling property

Qiang Lian et al.

Summary: In this study, a novel antibacterial coating with a degradable three-layer sandwich structure was designed, which achieved sustained antibacterial effects, promoted immune reconstitution, and achieved solid integration with bone tissue.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

In vitro application of drug-loaded hydrogel combined with 3D-printed porous scaffolds

Haokun Huang et al.

Summary: This study combines vancomycin-loaded hydrogel with 3D-printed porous titanium alloy scaffolds, providing a new approach for 3D printing of anti-infection titanium alloy stents.

BIOMEDICAL MATERIALS (2022)

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Article Biophysics

Strong adhesive and drug-loaded hydrogels for enhancing bone-implant interface fixation and anti-infection properties

Xingyue Wang et al.

Summary: A simple and low-cost hydrogel-based bone adhesive was prepared in this study to enhance the fixation ability and anti-infection ability of the bone-implant interface. The hydrogel exhibited good self-healing and strong adhesive ability, as well as excellent antibacterial effect and cytocompatibility.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Biophysics

Facile synthesis of black phosphorus-zinc oxide nanohybrids for antibacterial coating of titanium surface

Sivakumar Bose et al.

Summary: This study aimed to synthesize antibacterial nanohybrids and coat them on titanium bioimplant surface to improve their antibacterial activities. The results showed that the nanohybrids had photothermal effect against pathogenic bacteria under near-infrared light, inhibiting their growth effectively. The titanium surface coated with chitosan demonstrated better antibacterial activity, and there was no toxicity observed. Electochemical studies confirmed that the titanium surface coated with antibacterial agents had high corrosion resistance.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Materials Science, Multidisciplinary

Bifunctionalized hydrogels promote angiogenesis and osseointegration at the interface of three-dimensionally printed porous titanium scaffolds

Zhenjia Che et al.

Summary: Repairing severe bone defects is a challenge in orthopedics. Three-dimensional printing technology is used to create advanced bone tissue engineering scaffolds for promoting bone regeneration. In addition to osteogenic induction, angiogenesis is crucial for bone reconstruction. Researchers constructed a 3D-printed composite titanium scaffold system loaded with a thermosensitive collagen hydrogel containing vascular endothelial growth factor and bone morphogenetic protein-9. The system showed good biocompatibility and promoted angiogenesis and osseointegration in vivo. This study provides a theoretical basis for developing bioactive implant interfaces for patients with osteogenic defects.

MATERIALS & DESIGN (2022)

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Article Engineering, Biomedical

Construction of Wogonin Nanoparticle-Containing Strontium-Doped Nanoporous Structure on Titanium Surface to Promote Osteoporosis Fracture Repair

Dong Wang et al.

Summary: This study develops a functional nano-structured titanium implant that can regulate immune response in osteoporotic conditions and promote bone healing and new bone formation by releasing specific substances.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Construction and osteogenic effects of 3D-printed porous titanium alloy loaded with VEGF/BMP-2 shell-core microspheres in a sustained-release system

Zheng Liu et al.

Summary: The study developed a system using 3D-printed porous titanium alloy scaffold loaded with VEGF/BMP-2 shell-core microspheres for sequential release of VEGF and BMP-2. In vitro and in vivo experiments showed that this system effectively promoted osteogenic differentiation and bone integration.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Electrophoretic deposition of hydroxyapatite/chitosan nanocomposites: the effect of dispersing agents on the coating properties

M. S. Gaafar et al.

Summary: In this study, electrophoretic deposition was used to coat titanium substrate with a hydroxyapatite-chitosan composite in the presence of dispersing agents. The addition of dispersing agents improved the coating formation and stability, resulting in uniform and compact nanocomposite coatings. The coated titanium substrates exhibited high corrosion resistance, as indicated by the positive shift in corrosion potentials. The study also evaluated the stability of the coated substrates under different pH conditions and found potential applications in biomedicine.

RSC ADVANCES (2022)

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Review Engineering, Biomedical

Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review

Smriti Bohara et al.

Summary: The use of orthopedic implants in surgical technology has led to the restoration of physiological functions. However, there are various complications and limitations associated with these implants. Advancements in coating materials have shown potential in preventing implant failure, but most of these materials have not been successful in clinical tests. Implant failure rates have increased, resulting in physical discomfort and economic burdens. The development of systematic coating techniques has shown promising results in combating infection and enhancing bone integration.

BIOMATERIALS RESEARCH (2022)

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Article Materials Science, Biomaterials

Antibacterial properties of laser-encapsulated titanium oxide nanotubes decorated with nanosilver and covered with chitosan/Eudragit polymers

Lukasz Pawlowski et al.

Summary: In this study, titanium samples were modified to have a titanium oxide nanotubular surface and silver nanoparticles using electrochemical oxidation and sputtering techniques. A pH-sensitive chitosan/Eudragit 100 coating was further applied to achieve controlled release of antibacterial substances. The modified samples exhibited excellent wettability, corrosion resistance, and antibacterial properties.

BIOMATERIALS ADVANCES (2022)

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Article Materials Science, Biomaterials

Electrostatic self-assembly approach in the deposition of bio-functional chitosan-based layers enriched with caffeic acid on Ti-6Al-7Nb alloys by alternate immersion

Piotr Jablonski et al.

Summary: In this study, electrostatic self-assembly was used to fabricate biopolymer-based coatings on titanium alloy surfaces. The resulting coatings showed good corrosion resistance, antioxidant properties, biocompatibility, and antibacterial activity, making them suitable for implant functionalization.

BIOMATERIALS ADVANCES (2022)

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Article Engineering, Biomedical

Improving bactericidal performance of implant composite coatings by synergism between Melittin and tetracycline

Vahid Zarghami et al.

Summary: This study explored the synergistic effects of Melittin and tetracycline in preventing MRSA-associated bone implant infection. The chitosan/bioactive glass/tetracycline/Melittin coating showed both osteogenic and promising antibacterial activity.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2022)

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Article Dentistry, Oral Surgery & Medicine

Insulin growth factor binding protein-3 enhances dental implant osseointegration against methylglyoxal-induced bone deterioration in a rat model

Jyoti Shrestha Takanche et al.

Summary: This study investigated the effect of IGFBP-3 on inhibiting glucose oxidative stress and promoting bone formation in a rat model of MGO-induced bone loss. The results showed that IGFBP-3 could inhibit oxidative stress and inflammation, enhance osteogenesis, and promote the osseointegration of dental implants in patients with diabetes.

JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE (2022)

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Article Engineering, Biomedical

A multifunctional hydrogel coating to direct fibroblast activation and infected wound healing via simultaneously controllable photobiomodulation and photodynamic therapies

Ye He et al.

Summary: This study explores the PBM concept using 660 nm laser-triggered photodynamic therapy (PDT) to simplify the material system and achieve antibacterial activity and biological modulation effects. The research combines PBM with a PDT-based material system to develop a hydrogel coating with antibacterial activity and fibroblast activation ability.

BIOMATERIALS (2021)

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Article Materials Science, Coatings & Films

Thermo-sensitive hydrogel on anodized titanium surface to regulate immune response

Baoe Li et al.

Summary: The thermo-sensitive hydrogel introduced in the study can regulate immune response by intelligently identifying and adjusting the physiological environment according to temperature changes, meeting different immune demands. By changing the temperature of the hydrogel, macrophages can be rapidly transformed between the inflammatory and healing stages, achieving the purpose of antibiosis or tissue repair.

SURFACE & COATINGS TECHNOLOGY (2021)

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Article Engineering, Biomedical

Resorbable additively manufactured scaffold imparts dimensional stability to extraskeletally regenerated bone

C. Vaquette et al.

Summary: The study demonstrates that a highly porous, resorbable scaffold fabricated using additive manufacturing techniques enables reproducible extra-skeletal bone formation and prevents bone resorption. Additionally, it shows that additively manufactured biphasic scaffolds functionalized with BMP-2 facilitate dimensionally stable bone regeneration that supports dental implant osseointegration.

BIOMATERIALS (2021)

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Article Materials Science, Multidisciplinary

Microstructures and biological properties of 3D-printed titanium intervertebral spacer with the tri-calcium phosphate loaded demineralized bone matrix hydrogel

Hoe-Jin Kang et al.

Summary: This study aimed to enhance the osteogenic ability of 3D-printed porous titanium intervertebral spacer by loading Tri-calcium Phosphate (TCP) and Demineralized Bone Matrix (DBM), which was shown to be biocompatible and promote bone regeneration in both in-vitro and in-vivo studies.

MATERIALS LETTERS (2021)

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Article Materials Science, Biomaterials

Construction of a TiO2/MoSe2/CHI coating on dental implants for combating Streptococcus mutans infection

Maozhou Chai et al.

Summary: A MoSe2/TiO2/CHI hybrid coating was developed on dental implants to provide excellent antibacterial activity under NIR light, improving biocompatibility and promoting osseointegration even in the presence of infection. This light-assisted antibacterial coating shows great potential for dental implant applications.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Controlled release of dopamine coatings on titanium bidirectionally regulate osteoclastic and osteogenic response behaviors

Mingyue Wang et al.

Summary: This study successfully developed a surface modification method by loading DA on titanium implants, achieving controlled release for bone resorption and regeneration, as well as enhancing bone remodeling around the implants.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Calcium Peroxide Nanoparticles-Embedded Coatings on Anti-Inflammatory TiO2 Nanotubes for Bacteria Elimination and Inflammatory Environment Amelioration

Ye He et al.

Summary: The study developed a dual drug-loading system on titanium surface, which effectively achieved both antibacterial and anti-inflammatory properties, capable of killing bacteria and modulating pro-inflammatory reactions. This system shows great therapeutic potential in effectively killing pathogens and inhibiting pro-inflammatory reactions related to implant-associated infections.

SMALL (2021)

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Article Engineering, Chemical

Articular Cartilage Inspired the Construction of LTi-DA-PVA Composite Structure with Excellent Surface Wettability and Low Friction Performance

Lingling Cui et al.

Summary: A novel 'soft-hard' structure was designed for improving the surface wettability and tribological properties of Ti6Al4V alloy for artificial joints, fabricated through laser texturing, surface dopamine modification, and PVA hydrogel casting. The synergistic effect of the lower Ti6Al4V substrate's load-bearing capacity and the upper PVA hydrogel layer's biphasic lubrication resulted in a significantly reduced friction coefficient, similar to natural cartilage. The introduction of dopamine significantly enhanced the interfacial bonding performance between the substrate and the hydrogel layer, providing an effective method for enhancing the surface properties of Ti6Al4V as artificial joints.

TRIBOLOGY LETTERS (2021)

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Article Polymer Science

Transglutaminase Cross-Linked Gelatin-Alginate-Antibacterial Hydrogel as the Drug Delivery-Coatings for Implant-Related Infections

Chung-Kai Sun et al.

Summary: The study aims to establish an effective antibiotic slow-release system and evaluate its efficacy in preventing implant-related infections through an animal model experiment.

POLYMERS (2021)

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Article Chemistry, Physical

Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

Yanru Ren et al.

Summary: High failure rates of infection-related titanium implants can be improved with a novel bioactive surface coating containing silver nanoparticles loaded in a mussel-inspired carboxymethyl chitosan hydrogel. The coating enhances antibacterial properties without affecting cell proliferation. The surface properties of the titanium alloy were modified to facilitate strong bonding with the hydrogel and enhance antibacterial effectiveness.

MATERIALS (2021)

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Article Engineering, Biomedical

Development of novel bone-like nanocomposite coating of hydroxyapatite/collagen on titanium by modified electrophoretic deposition

Kaori Iwanami-Kadowaki et al.

Summary: EPD is a simple, rapid, and inexpensive technique for uniform coatings with controlled thicknesses. The modified EPD technique using Mg2+ ions successfully coated HAp/Col on a Ti substrate with controlled thickness, drastically increasing adhesive strength compared to non-Mg2+ EPD coating. The new coating showed potential for applications in instruments requiring rapid osseointegration at the bone-implant surface.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Biotechnology & Applied Microbiology

Sustained Release of VEGF to Promote Angiogenesis and Osteointegration of Three-Dimensional Printed Biomimetic Titanium Alloy Implants

Youbin Li et al.

Summary: This study focuses on a porous scaffold/thermosensitive hydrogel system with growth factor, aiming to promote angiogenesis and bone integration. In vivo validation showed that the composite scaffold facilitates angiogenesis-mediated bone regeneration and enhances bone integration significantly. The findings suggest that the composite scaffold provides bioactive VEGF, excellent biocompatibility, and crucial theoretical support for local blood supply restoration and bone integration reinforcement.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy

Jin Leng et al.

Summary: A hybrid hydrogel coating was constructed on ZnO structure of titanium, demonstrating enzymatic-degradability when bacteria exist and antibacterial activity. The coating provided a stable buffer zone for cell ingrowth and soft tissue integration, while reducing ZnO toxicity and improving fibroblast viability. This study proposes a self-adaptive strategy for ZnO improvement, preserving both antibacterial ability and soft tissue compatibility under different conditions.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Biomimetic Ti-6Al-4V alloy/gelatin methacrylate hybrid scaffold with enhanced osteogenic and angiogenic capabilities for large bone defect restoration

Limin Ma et al.

Summary: Titanium-based scaffolds are commonly used for bone defect treatment, but conventional implants lack adequate biomechanical properties for bone integration. A novel Ti-6Al-4V alloy/GelMA hybrid scaffold (GMPT) was developed with dual bionic features for bone defect repair, showing improved osteogenic and angiogenic capabilities. The concentration of GelMA significantly influenced gene expression related to bone formation and angiogenesis pathways in the GMPT scaffold, demonstrating promise for large bone defect restoration.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Practical strategy to construct anti-osteosarcoma bone substitutes by loading cisplatin into 3D-printed titanium alloy implants using a thermosensitive hydrogel

Zehao Jing et al.

Summary: The use of 3D-printed titanium alloy implants loaded with cisplatin within a hydrogel is a safe and effective treatment option for osteosarcoma-caused bone defects, providing both anti-tumor and bone repair functions. In vitro experiments confirmed the anti-tumor effects of the implants, while in vivo studies demonstrated long-term bone growth and osseointegration of the implants.

BIOACTIVE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

High-Strength, Strongly Bonded Nanocomposite Hydrogels for Cartilage Repair

Shikha Awasthi et al.

Summary: Polyacrylamide-based hydrogels were strengthened using titanium oxide (TiO2) and carbon nanotubes (CNTs) alone and combined in a matrix, resulting in improved mechanical properties and puncture resistance. The synergistic effect of TiO2 and CNT nanoparticles with PAM led to high compressive strength and elastic modulus, as well as significant self-healing and cytocompatibility. The stability and structural features of the PAM-TiO2-CNT composite were analyzed using density functional theory (DFT), showing promising potential for cartilage repair applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Orthopedics

Synthetic PVA Osteochondral Implants for the Knee Joint: Mechanical Characteristics During Simulated Gait

Tony Chen et al.

Summary: The study found that femoral osteochondral defects cause a redistribution of contact stress during simulated gait. The results showed that polyvinyl alcohol implants combined with porous metal bases can significantly improve joint contact mechanics, especially the implants consisting of a 20% PVA disk mounted on a pTi base demonstrated significant improvements in most parameters.

AMERICAN JOURNAL OF SPORTS MEDICINE (2021)

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Article Orthopedics

3D printing of dual-cell delivery titanium alloy scaffolds for improving osseointegration through enhancing angiogenesis and osteogenesis

Heng Zhao et al.

Summary: The study developed a 3D printed porous Ti6Al4V scaffold filled with BMSC and EPC loaded hydrogel, enhancing osteogenesis and angiogenesis to efficiently repair bone defects. The optimized pore structure of the scaffold promoted bone ingrowth and blood vessel formation. The composite implant up-regulated the expression of osteogenesis and angiogenesis-related genes, showing promise for improving osseointegration.

BMC MUSCULOSKELETAL DISORDERS (2021)

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Article Biochemistry & Molecular Biology

Electrochemically deposition of catechol-chitosan hydrogel coating on coronary stent with robust copper ions immobilization capability and improved interfacial biological activity

Beilei Wang et al.

Summary: This study presents a green and facile electrobiofabrication method to construct a bioactive hydrogel coating on coronary stent and titanium surfaces, which can significantly enhance interfacial biological activity. The coating, with copper ions immobilized, demonstrates excellent mechanical properties and cell biocompatibility, showing great potential for biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva

Yangyang Duan et al.

Summary: In this study, a self-strengthening coating was successfully constructed using silver nanoparticles, chitosan, and sodium alginate, which exhibited enhanced corrosion resistance and antibacterial properties. The coating continuously strengthened in corrosive medium, showing high protection efficiency.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

A novel tunable, highly biocompatible and injectable DNA-chitosan hybrid hydrogel fabricated by electrostatic interaction between chitosan and DNA backbone

Fanghao Chen et al.

Summary: A new injectable DNA hydrogel was synthesized through heat-cool treatments and chitosan cross-linkage, showing excellent biocompatibility and drug delivery properties.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Nanoscience & Nanotechnology

Coating Polyelectrolyte Multilayers Loaded with Quercetin on Titanium Surfaces by Layer-By-Layer Assembly Technique to Improve Surface Osteogenesis Under Osteoporotic Condition

Bingzhang Wang et al.

Summary: A controlled release system of quercetin was successfully established on the surface of titanium implants, improving osseointegration under osteoporotic conditions. This study proposed a new implant therapy strategy for patients with osteoporosis, demonstrating higher osteogenic effects and new bone formation around the implant.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Review Chemistry, Physical

Biochemical Modification of Titanium Oral Implants: Evidence from In Vivo Studies

Saturnino Marco Lupi et al.

Summary: The discovery of osseointegration of titanium implants has revolutionized the field of dental prosthesis. Through biochemical modification techniques, biomolecules are immobilized on implant surfaces to enhance the interaction with biological tissues, promoting the quality of osseointegration.

MATERIALS (2021)

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Article Immunology

A Novel Strategy to Coat Dopamine-Functionalized Titanium Surfaces With Agarose-Based Hydrogels for the Controlled Release of Gentamicin

H. Melis Soylu et al.

Summary: In this study, a hydrogel-based coating for controlled release of gentamicin has been developed. The coating showed good surface properties, low cytotoxicity, and strong antibacterial effects, making it a promising approach for modifying spinal implants and improving their application in orthopedic surgery.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Proceedings Paper Materials Science, Multidisciplinary

An updated review on surface functionalisation of titanium and its alloys for implants applications

J. Alipal et al.

Summary: This review paper focuses on the deposition of bioactive and degradable coatings on titanium implants to enhance cell anchorage and facilitate osseointegration. It discusses the surface functionality of titanium and ways to adjust its surface for biomedical applications, as well as challenges and mechanisms for adapting coated surfaces to bioimplanted environments. The review also explores the use of 3D-printing technology for implant surface modification and contributes to the concept of biocompatible coated titanium.

MATERIALS TODAY-PROCEEDINGS (2021)

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Article Dentistry, Oral Surgery & Medicine

Effect of Cathodic Arc Plasma Deposition on Shear Bond Strength between Palladium Cobalt Chromium Coated with Titanium Nitride and Titanium Aluminium Nitride with Ceramic

Vaishnavi Prabhakar et al.

Summary: The success of esthetic ceramo-metal restoration is highly dependent on bond strength. This study aimed to evaluate the shear bond strength between different coated alloys and feldspathic ceramics, with the alloy coated with titanium aluminum nitride showing the highest bond strength.

CONTEMPORARY CLINICAL DENTISTRY (2021)

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Article Materials Science, Multidisciplinary

Bioactive conformable hydrogel-carbonated hydroxyapatite nanocomposite coatings on Ti-6Al-4V substrates

Kyung-Ah Kwon et al.

MATERIALS TECHNOLOGY (2020)

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Article Engineering, Biomedical

Construction of multilayered molecular reservoirs on a titanium alloy implant for combinational drug delivery to promote osseointegration in osteoporotic conditions

Maohua Chen et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Environmental

Photo-responsive chitosan/Ag/MoS2 for rapid bacteria-killing

Min Zhu et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Surface Treatment of Acetabular Cups with a Direct Deposition of a Composite Nanostructured Layer Using a High Electrostatic Field

Marek Pokorny et al.

MOLECULES (2020)

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Article Nanoscience & Nanotechnology

Encapsulated bacteriophages in alginate-nanohydroxyapatite hydrogel as a novel delivery system to prevent orthopedic implant-associated infections

Joana Alberta Ribeiro Barros et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Biophysics

Effects of statherin on the biological properties of titanium metals subjected to different surface modification

Xugang Lu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Nanoscience & Nanotechnology

Surface Functionalization with Proanthocyanidins Provides an Anti-Oxidant Defense Mechanism That Improves the Long-Term Stability and Osteogenesis of Titanium Implants

Jiahao Tang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Pharmacology & Pharmacy

Calcium alginate template-mineral substituted hydroxyapatite hydrogel coated titanium implant for tibia bone regeneration

XinHua Yin et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Engineering, Biomedical

Antibacterialgraphene-basedhydroxyapatite/chitosan coating with gentamicin for potential applications in bone tissue engineering

Milena Stevanovic et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Materials Science, Multidisciplinary

Non-RGD peptide H-ckrwwkwirw-NH2 grafting accentuates antibacterial and osteoinductive properties of biopolymer coating

Hsin-Yi Lin et al.

SOFT MATERIALS (2020)

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Article Polymer Science

Tribological properties of hierarchical structure artificial joints with poly acrylic acid (AA)-poly acrylamide (AAm) hydrogel and Ti6Al4V substrate

Yaling Deng et al.

JOURNAL OF POLYMER RESEARCH (2020)

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Article Materials Science, Multidisciplinary

Mussel-inspired construction of Ti6Al4V-hydrogel artificial cartilage material with high strength and low friction

Kai Chen et al.

MATERIALS LETTERS (2020)

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Review Biochemical Research Methods

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

Farhad Abasalizadeh et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2020)

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Article Materials Science, Biomaterials

Synergistic regulation of osteoimmune microenvironment by IL-4 and RGD to accelerate osteogenesis

Mengting Li et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Materials Science, Biomaterials

1α,25-Dihydroxyvitamin D3-loaded hierarchical titanium scaffold enhanced early osseointegration

Ping He et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Chemistry, Multidisciplinary

Poly-L-lysine/Sodium Alginate Coating Loading Nanosilver for Improving the Antibacterial Effect and Inducing Mineralization of Dental Implants

Chuchu Guo et al.

ACS OMEGA (2020)

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Article Chemistry, Multidisciplinary

Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant

Yuan Li et al.

ACS NANO (2020)

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Article Biotechnology & Applied Microbiology

Biomimetic titanium implant coated with extracellular matrix enhances and accelerates osteogenesis

Yu Wu et al.

NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration

Minxun Lu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

Long acting anti-infection constructs on titanium

Stefano Perni et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Infectious Diseases

Antibacterial Property and Biocompatibility of Silver, Copper, and Zinc in Titanium Dioxide Layers Incorporated by One-Step Micro-Arc Oxidation: A Review

Masaya Shimabukuro

ANTIBIOTICS-BASEL (2020)

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Article Dentistry, Oral Surgery & Medicine

Chitosal/hydroxyapatite composite coatings on porous Ti6Al4V titanium implants: in vitro and in vivo studies

Ting Zhang et al.

JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE (2020)

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Article Materials Science, Biomaterials

3D printed porous titanium cages filled with simvastatin hydrogel promotes bone ingrowth and spinal fusion in rhesus macaques

Wen Zhang et al.

BIOMATERIALS SCIENCE (2020)

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Article Cell & Tissue Engineering

PROPHYLAXIS OF IMPLANT-RELATED INFECTIONS BY LOCAL RELEASE OF VANCOMYCIN FROM A HYDROGEL IN RABBITS

W. Boot et al.

EUROPEAN CELLS & MATERIALS (2020)

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Article Materials Science, Biomaterials

Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration

Sangmin Lee et al.

BIOMATERIALS SCIENCE (2020)

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Article Materials Science, Biomaterials

Dual light-induced in situ antibacterial activities of biocompatibleTiO(2)/MoS2/PDA/RGD nanorod arrays on titanium

Guannan Zhang et al.

BIOMATERIALS SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Enhanced Osseointegration of Titanium Implants by Surface Modification with Silicon-doped Titania Nanotubes

Xijiang Zhao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Cell & Tissue Engineering

The combination of multi-functional ingredients-loaded hydrogels and three-dimensional printed porous titanium alloys for infective bone defect treatment

Shichong Qiao et al.

JOURNAL OF TISSUE ENGINEERING (2020)

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Article Materials Science, Biomaterials

Recombinant human bone morphogenetic protein-2 loaded porous β-tricalcium phosphate microsphere-hyaluronic acid composites promoted osseointegration around titanium implants

Jae Hyup Lee et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2019)

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Article Materials Science, Biomaterials

Recombinant human bone morphogenetic protein-2 loaded porous β-tricalcium phosphate microsphere-hyaluronic acid composites promoted osseointegration around titanium implants

Jae Hyup Lee et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2019)

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Article Chemistry, Applied

Surface modification of Ti-6Al-4V alloy for osseointegration by alkaline treatment and chitosan-matrix glass-reinforced nanocomposite coating

S. Rastegari et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biochemistry & Molecular Biology

Biomimetic Surfaces Coated with Covalently Immobilized Collagen Type I: An X-Ray Photoelectron Spectroscopy, Atomic Force Microscopy, Micro-CT and Histomorphometrical Study in Rabbits

Antonio Scarano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Orthopedics

Is Implant Coating With Tyrosol- and Antibiotic-loaded Hydrogel Effective in Reducing Cutibacterium (Propionibacterium) acnes Biofilm Formation? A Preliminary In Vitro Study

Konstantinos Tsikopoulos et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2019)

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Article Biophysics

BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement

Bailong Tao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Chemistry, Multidisciplinary

Hydrogel Paint

Xi Yao et al.

ADVANCED MATERIALS (2019)

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Article Materials Science, Biomaterials

Controlled release of BMP-2 from titanium with electrodeposition modification enhancing critical size bone formation

Fu-Yuan Teng et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Materials Science, Biomaterials

Functionalization of titanium substrate with multifunctional peptide OGP-NAC for the regulation of osteoimmunology

Ju Liu et al.

BIOMATERIALS SCIENCE (2019)

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Article Cell & Tissue Engineering

Design and biological functionality of a novel hybrid Ti-6Al-4V/hydrogel system for reconstruction of bone defects

Alok Kumar et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Biophysics

Bio-functionalization of grade V titanium alloy with type I human collagen for enhancing and promoting human periodontal fibroblast cell adhesion - an in-vitro study

Jitendra Sharan et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Biochemistry & Molecular Biology

Enhanced antimicrobial activity of naturally derived bioactive molecule chitosan conjugated silver nanoparticle against dental implant pathogens

Darshan Devang Divakar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Engineering, Biomedical

Dual-inflammatory cytokines on TiO2 nanotube-coated surfaces used for regulating macrophage polarization in bone implants

Lili Gao et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

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Article Nanoscience & Nanotechnology

Promotion of Osseointegration Using Protamine/Alginate/Bone Morphogenic Protein 2 Biofunctionalized Composite Coating on Nanopolymorphic Titanium Surfaces

Tao Chen et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

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Article Materials Science, Multidisciplinary

Graphene Oxide Hybrid Supramolecular Hydrogels with Self-Healable, Bioadhesive and Stimuli-Responsive Properties and Drug Delivery Application

Yunhua Chen et al.

MACROMOLECULAR MATERIALS AND ENGINEERING (2018)

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Article Materials Science, Biomaterials

Mussel-Inspired Peptide Coatings on Titanium Implant to Improve Osseointegration in Osteoporotic Condition

Huan Zhao et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

Mussel-Inspired Peptide Coatings on Titanium Implant to Improve Osseointegration in Osteoporotic Condition

Huan Zhao et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Engineering, Biomedical

Antibacterial and immunogenic behavior of silver coatings on additively manufactured porous titanium

M. Croes et al.

ACTA BIOMATERIALIA (2018)

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Article Biophysics

Construction of Ag-incorporated coating on Ti substrates for inhibited bacterial growth and enhanced osteoblast response

Zhang Yuan et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Materials Science, Biomaterials

Gelatin Hydrogel Combined with Polydopamine Coating To Enhance Tissue Integration of Medical Implants

Thanh N. Dinh et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Nanoscience & Nanotechnology

Loading icariin on titanium surfaces by phase-transited lysozyme priming and layer-by-layer self-assembly of hyaluronic acid/chitosan to improve surface osteogenesis ability

Yunjia Song et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Materials Science, Biomaterials

Gentamicin-Loaded Bioactive Hydroxyapatite/Chitosan Composite Coating Electrodeposited on Titanium

Milena Stevanovic et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Biochemistry & Molecular Biology

Biocompatible Coatings from Smart Biopolymer Nanoparticles for Enzymatically Induced Drug Release

Christian Tolle et al.

BIOMOLECULES (2018)

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Article Dentistry, Oral Surgery & Medicine

The effect of different collagen modifications for titanium and titanium nitrite surfaces on functions of gingival fibroblasts

U. Ritz et al.

CLINICAL ORAL INVESTIGATIONS (2017)

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Article Biochemistry & Molecular Biology

In Vitro and In Vivo Evaluation of Tetracycline Loaded Chitosan-Gelatin Nanosphere Coatings for Titanium Surface Functionalization

Kena Ma et al.

MACROMOLECULAR BIOSCIENCE (2017)

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Article Engineering, Biomedical

Corrosion resistance and biological activity of TiO2 implant coatings produced in oxygen-rich environments

Rui Zhang et al.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE (2017)

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Article Engineering, Biomedical

Effects of controlled micro-/nanosurfaces on osteoblast proliferation

Natsuko Iwata et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

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Article Materials Science, Biomaterials

Biomimetic collagen/phospholipid coatings improve formation of hydroxyapatite nanoparticles on titanium

Gilia C. M. Ruiz et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Biotechnology & Applied Microbiology

The Incorporation of Strontium in a Sodium Alginate Coating on Titanium Surfaces for Improved Biological Properties

Ning Yuan et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Review Physiology

Surface Modification of Dental Titanium Implant by Layer-by-Layer Electrostatic Self-Assembly

Quan Shi et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Article Biophysics

Biofunctional polyethylene glycol coatings on titanium: An in vitro-based comparison of functionalization methods

Judit Buxadera-Palomero et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis

Hao Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Multifunctions of dual Zn/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants

Yiqiang Yu et al.

ACTA BIOMATERIALIA (2017)

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Article Multidisciplinary Sciences

Titanium Surface Priming with Phase-Transited Lysozyme to Establish a Silver Nanoparticle-Loaded Chitosan/Hyaluronic Acid Antibacterial Multilayer via Layer-by-Layer Self-Assembly

Xue Zhong et al.

PLOS ONE (2016)

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Article Engineering, Biomedical

Incorporating simvastatin/poloxamer 407 hydrogel into 3D-printed porous Ti6Al4V scaffolds for the promotion of angiogenesis, osseointegration and bone ingrowth

Hao Liu et al.

BIOFABRICATION (2016)

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Article Dentistry, Oral Surgery & Medicine

Pilot study of gingival connective tissue responses to 3-dimensional collagen nanofiber-coated dental implants

Yuki Raita et al.

DENTAL MATERIALS JOURNAL (2015)

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Article Chemistry, Multidisciplinary

Quaternised chitosan coating on titanium provides a self-protective surface that prevents bacterial colonisation and implant-associated infections

Zhaoxiang Peng et al.

RSC ADVANCES (2015)

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Article Engineering, Biomedical

In vivo evaluation of bone deposition in macroporous titanium implants loaded with mesenchymal stem cells and strontium-enriched hydrogel

Arianna B. Lovati et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2015)

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Article Chemistry, Physical

Room-temperature attachment of PLGA microspheres to titanium surfaces for implant-based drug release

Dongqin Xiao et al.

APPLIED SURFACE SCIENCE (2014)

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Article Dentistry, Oral Surgery & Medicine

Layer-by-layer self-assembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation

Hongbin Lv et al.

JOURNAL OF DENTISTRY (2014)

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Article Materials Science, Biomaterials

Gelatin functionalised porous titanium alloy implants for orthopaedic applications

E. Vanderleyden et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2014)

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Article Chemistry, Multidisciplinary

Electrospun Collagen Mimicking the Reconstituted Extracellular Matrix Improves Osteoblastic Differentiation Onto Titanium Surfaces

Michele Iafisco et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2013)

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Article Materials Science, Biomaterials

Investigation on the effect of collagen and vitamins on biomimetic hydroxyapatite coating formation on titanium surfaces

Gabriela Ciobanu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Biotechnology & Applied Microbiology

Modification of macroporous titanium tracheal implants with biodegradable structures: Tracking in vivo integration for determination of optimal in situ epithelialization conditions

Nihal Engin Vrana et al.

BIOTECHNOLOGY AND BIOENGINEERING (2012)

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Article Surgery

In vivo Analysis of Tissue Response to Plasma-Treated Collagen-I-Coated Titanium Alloys

J. Hauser et al.

EUROPEAN SURGICAL RESEARCH (2009)

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Article Biochemical Research Methods

Analytical investigations of poly(acrylic acid) coatings electrodeposited on titanium-based implants: a versatile approach to biocompatibility enhancement

E. De Giglio et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2007)

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Article Dentistry, Oral Surgery & Medicine

The integration of chitosan-coated titanium in bone:: An in vivo study in rabbits

Joel D. Bumgardner et al.

IMPLANT DENTISTRY (2007)

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Article Engineering, Biomedical

Modification of Ti6Al4V surfaces using collagen I, III, and fibronectin. II. Influence on osteoblast responses

S Bierbaum et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2003)

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Article Dentistry, Oral Surgery & Medicine

In vitro study of collagen coating of titanium implants for initial cell attachment

M Nagai et al.

DENTAL MATERIALS JOURNAL (2002)

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Article Engineering, Biomedical

Proliferation and differentiation of rat calvarial osteoblasts on type I collagen-coated titanium alloy

D Becker et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)

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Article Biochemistry & Molecular Biology

Structural and rheological properties of methacrylamide modified gelatin hydrogels

AI Van den Bulcke et al.

BIOMACROMOLECULES (2000)

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