☆ 4.7 Review

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

GELS (2023)

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Article Pharmacology & Pharmacy

Sustained delivery of CpG oligodeoxynucleotide by acetalated dextran microparticles augments effector response to Computationally Optimized Broadly Reactive Antigen (COBRA) influenza hemagglutinin

Cole J. Batty et al.

Summary: A subunit or protein-based influenza vaccine can be a safer alternative to live attenuated or inactivated vaccines. In this study, a method for encapsulating the adjuvant CpG in hydrophobic microparticles was developed. The slow-degrading particles showed the highest level of innate immune stimulation and sustained release particles elicited the highest levels of antibody effector functions. These findings suggest that sustained release of CpG from microparticles could potentially enhance the efficacy of subunit vaccines.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Virology

A vaccine delivery system promotes strong immune responses against SARS-CoV-2 variants

Zhiwei Lei et al.

Summary: A vaccine delivery system has been developed to enhance durable cellular and humoral immune responses against broad SARS-CoV-2 variants.

JOURNAL OF MEDICAL VIROLOGY (2023)

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Review Polymer Science

The evolution of the global COVID-19 epidemic in Morocco and understanding the different therapeutic approaches of chitosan in the control of the pandemic

Youssef Ait Hamdan et al.

Summary: COVID-19 is a severe flu that negatively affects lung and respiratory organ functions. The virus can be transmitted through contact with infected individuals or their respiratory droplets. Chitosan, a natural polymer, has been found to inhibit COVID-19 infection and repair damaged tissue. Understanding the mechanisms of chitosan in controlling COVID-19 could lead to innovative strategies in the medical field.

POLYMER BULLETIN (2023)

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Article Oncology

Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma A Phase 2 Randomized Clinical Trial

Irene Y. Cheung et al.

Summary: This clinical trial investigated the effects of oral beta-glucan adjuvant during vaccine priming in patients with high-risk neuroblastoma. It was found that adding oral beta-glucan increased anti-GD2 IgG1 antibody levels without additional toxic effects. However, alternative adjuvants may be needed to improve seroconversion rates.

JAMA ONCOLOGY (2023)

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Article Chemistry, Multidisciplinary

Blood Clot Scaffold Loaded with Liposome Vaccine and siRNAs Targeting PD-L1 and TIM-3 for Effective DC Activation and Cancer Immunotherapy

Yitong Chen et al.

Summary: An implantable blood clot loaded with LPH-vaccine and LPHsiRNA is used to recruit and activate dendritic cells, improving the efficacy of tumor vaccines and reducing immunosuppressive signals. This strategy has shown promising results in mouse models and has the potential for personalized therapy.

ACS NANO (2023)

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Review Polymer Science

The State of the Art of Natural Polymer Functionalized Fe3O4 Magnetic Nanoparticle Composites for Drug Delivery Applications: A Review

Abu Hassan Nordin et al.

Summary: Natural polymers have gained significant attention for their potential role in the encapsulation and transportation of pharmaceuticals. This review focuses on drug delivery systems (DDS) constructed using representative natural polymers from animals, plants, and microbes. To enhance the efficiency of polymers in DDS, the incorporation of Fe3O4 magnetic nanoparticles has been widely explored due to their unique characteristics. This review provides an overview of recent progress in using natural polymeric Fe3O4 magnetic nanoparticles for drug delivery applications based on different polymer origins.

GELS (2023)

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Article Allergy

Are gelatin-containing vaccines safe to give in alpha-gal sensitized patients?

Saira Zafar et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Chemistry, Physical

A chitosan-mediated inhalable nanovaccine against SARS-CoV-2

Shao-Hua Zhuo et al.

Summary: This study presents an inhalable nanovaccine consisting of chitosan and SARS-CoV-2 spike protein, which induces a strong immune response and enhances local mucosal immunity in the lungs, potentially protecting against the virus.

NANO RESEARCH (2022)

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Article Materials Science, Biomaterials

Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery

Kengo Suzuki et al.

Summary: Hyaluronic acid-coated biodegradable polymeric micelles are promising platforms for developing nasal vaccines, as they efficiently deliver antigens and adjuvants to mucosal-resident immune cells and promote immune responses.

BIOMATERIALS SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection

Barbara Voros-Horvath et al.

Summary: This article presents a systematic study on the preparation of chitosan hydrogels with dicarboxylic acids and their characterization. Chemically cross-linked chitosan hydrogels can be synthesized using malic or glutaric acid without additives or catalysts. The hydrogels show adsorption capacity for ACE2 inhibitors, providing a basis for their use in nasal formulations to reduce the risk of COVID-19 infection.

ACS OMEGA (2022)

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Article Chemistry, Multidisciplinary

Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage

Qilin Li et al.

Summary: This study developed a mushroom-inspired micro-needle platform for the delivery of COVID-19 vaccines and on-site recording of vaccination information. The system can be easily pressed into the skin and detached, acting as a tattoo to record vaccination counts. It showed promising results in terms of immunogenicity and offers a convenient and efficient method for vaccine delivery and storage.

ACS NANO (2022)

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Article Biochemistry & Molecular Biology

Injectable Slow-Release Hydrogel Formulation of a Plant Virus-Based COVID-19 Vaccine Candidate

Christian Isalomboto Nkanga et al.

Summary: By formulating CPMV nanoparticles in injectable hydrogels, slow release and prolonged immunostimulation can be achieved, eliminating the need for multiple doses. When used as a vaccine platform, the hydrogel can elicit sustained antibody response for up to 20 weeks, making it a promising single-dose vaccine for future pandemics.

BIOMACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Recent advances on chitosan as an adjuvant for vaccine delivery

Isra Dmour et al.

Summary: Chitosan is a natural polymer with wide applications in the field of drugs, vaccines, and antigen delivery. It has unique properties that make it a promising adjuvant in vaccine delivery. Studies have shown that nanoparticles loaded with chitosan and its derivatives can induce immune responses. The physicochemical properties of chitosan provide an excellent opportunity for engineering antigen-specific adjuvant/delivery systems.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Engineering, Biomedical

Chitosan nanoparticles containing fusion protein (Hspx-PPE44-EsxV) and resiquimod adjuvant (HPERC) as a novel booster vaccine for Mycobacterium tuberculosis

Rasul Hoseinpur et al.

Summary: This study aimed to evaluate the immunogenicity of chitosan nanoparticles containing fusion protein and resiquimod adjuvant in mice. The results showed that priming with BCG followed by boosting with chitosan nanoparticles vaccine resulted in higher levels of immune response.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Article Pharmacology & Pharmacy

Evaluation of the usefulness of hydroxypropyl cellulose and sucrose in the nasal influenza vaccine

Shiuhei Mieda et al.

Summary: The study demonstrated the feasibility of utilizing hydroxypropyl cellulose and sucrose as excipients to stabilize powdered nasal influenza vaccines.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Immunology

Intranasal immunization with chitosan microparticles enhances LACK-DNA vaccine protection and induces specific long-lasting immunity against visceral leishmaniasis

Daniel Claudio Oliveira Gomes et al.

Summary: This study demonstrates that associating the LACK-DNA vaccine with chitosan microparticles enhances long-lasting immunity against late Leishmania infantum challenge. The vaccinated mice showed significantly lower parasite loads and increased spleen cell responsiveness to parasite antigens. Moreover, LACK-DNA/CMC vaccinated-infected mice exhibited better health condition.

MICROBES AND INFECTION (2022)

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Article Nanoscience & Nanotechnology

Adjuvant-free cellulose nanofiber vaccine induces permanent humoral immune response in mouse

Ronglin Ma et al.

Summary: Vaccines are effective strategies for dealing with infectious and noninfectious diseases, but studies have shown a decline in neutralizing antibody titers after vaccination. This study introduces a novel nanofiber as a vaccine carrier that can induce a long-term immune response by controlled release of antigens. Compared to other substances, this nanofiber can induce and maintain higher and longer antibody titers after vaccination.

NANOTECHNOLOGY (2022)

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Article Polymer Science

Natural-Fiber-Reinforced Chitosan, Chitosan Blends and Their Nanocomposites for Various Advanced Applications

Rushdan Ahmad Ilyas et al.

Summary: This review article focuses on the use of green composites from natural fibers, particularly chitosan, in the development of biodegradable materials. Natural fiber composites have numerous advantages such as durability, low cost, low weight, high specific strength, environmental friendliness, and biodegradability. Chitosan, a natural fiber, can be processed into various forms and has been found to possess high thermal stability and good physical and chemical properties. Chitosan-based green composites have wide applicability in industries such as biomedicine, cosmetology, papermaking, wastewater treatment, agriculture, and pharmaceuticals.

POLYMERS (2022)

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Article Polymer Science

Modulation of Chitosan-TPP Nanoparticle Properties for Plasmid DNA Vaccines Delivery

Renato Nunes et al.

Summary: Nucleic acid vaccines are a fast, safe, cost-effective, and efficient technology for combating viral infections. Developing methods to protect, carry, and deliver nucleic acids is crucial for ensuring their effectiveness.

POLYMERS (2022)

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Article Immunology

Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2

Khue G. Nguyen et al.

Summary: Despite the effectiveness of current COVID-19 vaccines, there are still opportunities for improvement. A subunit vaccine with enhanced thermostability was designed to improve vaccine access, and intranasal immunization was explored to prevent breakthrough infections. The study found that the designed vaccine platform has multiple advantages.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Albumin and interferon-β fusion protein serves as an effective vaccine adjuvant to enhance antigen-specific CD8+T cell-mediated antitumor immunity

Ssu-Hsueh Tseng et al.

Summary: The fusion of albumin to IFN beta (Alb-IFN beta) enhances immune function, prolongs the half-life of IFN beta, and has a significant antitumor effect. Alb-IFN beta can serve as an innovative adjuvant for vaccine development.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Biochemistry & Molecular Biology

Margetuximab and trastuzumab deruxtecan: New generation of anti-HER2 immunotherapeutic agents for breast cancer

Siti Muhamad Nur Husna et al.

Summary: The development of anti-HER2 monoclonal antibodies has significantly improved the treatment of HER2+ breast cancer, with new generation mAbs and ADCs approved for previously treated HER2+ MBC patients. Research on the mechanisms and clinical trials of anti-HER2 immunotherapies have renewed interest in the field, aiming to enhance efficacy in both HER2+ and HER2-low breast cancer patients.

MOLECULAR IMMUNOLOGY (2022)

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Article Chemistry, Applied

Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine

Rebecca Shu Ling Tan et al.

Summary: This review discusses the progress in the design and application of chitosan and its derivatives for their antiviral effects, as well as the potential of processing them into nanomedicine for higher antiviral efficacy. The aims of targeting SARS-CoV-2 and evolving virus strains with chitosan designs are also explored to meet pandemic preparedness at the early stages of outbreak.

CARBOHYDRATE POLYMERS (2022)

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Article Immunology

Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Qianyu Bai et al.

Summary: Researchers have developed a HEV vaccine using chitosan modified nano-graphene oxide as an adjuvant, which can enhance both cellular and humoral immune response, offering a promising solution to control HEV infection.

VACCINE (2022)

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Article Food Science & Technology

A Thermostable Dissolving Microneedle Vaccine with Recombinant Protein of Botulinum Neurotoxin Serotype A

Baohua Zhao et al.

Summary: In this study, a thermally stable and dissolving microneedle patch for delivering a recombinant protein vaccine against BoNT/A was developed using a fish gelatin matrix. The microneedle patch showed excellent mechanical properties and vaccination effect. The fish gelatin matrix protected the vaccine from protein denaturation under high temperature storage. This microneedle patch has the potential for rapid, painless, and large-scale vaccination.

TOXINS (2022)

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Article Chemistry, Multidisciplinary

STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant

Matthew D. Gallovic et al.

Summary: The current pandemic emphasizes the importance of effective vaccines against respiratory viruses. This study presents a vaccine strategy using a scalable microparticle platform containing a STING agonist as an adjuvant, which provides durable protection against the influenza virus. Animal studies demonstrate that this vaccine-adjuvant combination can reduce viral shedding, improve vaccine outcomes, and provide sustained protection even a year after a single dose.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Multidisciplinary Sciences

Mucosal immunity of mannose-modified chitosan microspheres loaded with the nontyepable Haemophilus influenzae outer membrane protein P6 in BALB/c mice

Yushuai Ma et al.

Summary: Nontypeable Haemophilus influenzae (NTHi) is a common opportunistic pathogen that causes otitis media in children and acute exacerbation of chronic obstructive pulmonary disease (COPD) in adults. P6-loaded mannose-modified chitosan microspheres (P6-MCMs) have been found to enhance humoral and cellular immune responses, effectively prevent NTHi infection, and reduce inflammation in the nasal mucosa and lung.

PLOS ONE (2022)

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Article Biochemistry & Molecular Biology

Single-helical formyl ß-glucan effectively deliver CpG DNA with poly(dA) to macrophages for enhanced vaccine effects

Yuying Xu et al.

Summary: In this study, a stable single helical β-glucan formyl derivative was developed as a DNA delivery platform, which showed low toxicity and high efficiency.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Pharmacology & Pharmacy

Development of multistage recombinant protein vaccine formulations against toxoplasmosis using a new chitosan and porin based adjuvant system

Selin Parmaksiz et al.

Summary: Toxoplasmosis is a global health problem, and developing a vaccine against this disease is a major goal. In this study, vaccine formulations containing multistage recombinant antigens were developed, and chitosan and Salmonella Typhi porins were used as adjuvants. Immunization of mice with these formulations resulted in enhanced immune responses and protection against T. gondii, particularly with the microparticulate form.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Chemistry, Multidisciplinary

Bridging nanoplatform and vaccine delivery, a landscape of strategy to enhance nasal immunity

Zhuang Teng et al.

Summary: Vaccination is urgently needed and effective in combating epidemics, cancers, allergies, and other diseases. Nasal administration of vaccines offers advantages over needle-based injection, including higher compliance and lower risk of infection. Nanoplatforms as delivery systems show potential in enhancing the immunogenic efficacy of nasal vaccines. This review provides an overview of strategies to overcome nasal barriers and discusses the application and future prospects of nanoplatforms in nasal vaccine administration.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Medicine, Research & Experimental

Application of liposomes in the treatment of infectious diseases

Nurfatihah Azlyna Ahmad Suhaimi et al.

Summary: This review discusses the limitations of current therapeutic drugs and vaccines, as well as the application of liposomes in the treatment of tuberculosis, malaria, and HIV infection.

LIFE SCIENCES (2022)

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Article Materials Science, Multidisciplinary

Versatility of acetalated dextran in nanocarriers targeting respiratory diseases

Parteek Prasher et al.

Summary: Acetalated dextran is a chemically modified polysaccharide that has potential applications in pulmonary drug delivery due to its biodegradability, sensitivity to acidic pH, high encapsulation efficacy, ability to chemically conjugate with pharmaceuticals, and ability to cross the mucosal layer.

MATERIALS LETTERS (2022)

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Article Virology

Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery

Keegan Braz Gomes et al.

Summary: In this study, the researchers demonstrated that encapsulating a conserved influenza ectodomain matrix-2 protein virus-like particle (M2e5x VLP) into a pre-crosslinked bovine serum albumin (BSA) polymeric matrix enhanced in vitro antigen immunogenicity and in vivo efficacy. The combination of M2e5x VLP microparticles with adjuvant microparticles showed increased expression of antigen-presenting molecules and induced high levels of specific antibodies and T-cell stimulation in mice. This research utilized the advantages of both VLP and polymeric delivery platforms to enhance antigen immunogenicity and adaptive immunity in vivo.

VIRUSES-BASEL (2022)

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Article Nanoscience & Nanotechnology

Enhanced Immune Responses to Mucosa by Functionalized Chitosan-Based Composite Nanoparticles as a Vaccine Adjuvant for Intranasal Delivery

Yuhong Lin et al.

Summary: N-2-hydroxypropyl trimethyl ammonium chloride chitosan/N,O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) were prepared and demonstrated to have excellent mucosal absorption and enhanced immune effects. These nanoparticles could promote lymphocyte proliferation and the secretion of pro-inflammatory factors, leading to stimulation of mucosal and systemic immune responses. Chitosan-based nano-delivery system has great promise as a mucosal vaccine adjuvant in viral infectious diseases and immunization therapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Materials Science, Biomaterials

HSA-templated self-generation of gold nanoparticles for tumor vaccine delivery and combinational therapy

Dan Zhang et al.

Summary: Drug delivery systems (DDS) are crucial in tumor vaccine construction and their therapeutic effect promotion. By utilizing the versatile binding sites and bioreduction ability of human serum albumin (HSA), self-generated gold nanoparticles (AuNPs) on HSA (HSA@AuNPs) can serve as a DDS that converts light into heat. These nanoparticles deliver peptides, enhance immune response, and achieve combined photothermal therapy and immunotherapy.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Pharmacology & Pharmacy

Immunological Assessment of Chitosan or Trimethyl Chitosan-Coated PLGA Nanospheres Containing Fusion Antigen as the Novel Vaccine Candidates Against Tuberculosis

Sirwan Zare et al.

Summary: This study aimed to evaluate the immune efficacy of multi-subunit vaccines against Mycobacterium Tuberculosis using surface-modified PLGA nanoparticles. The vaccines showed potential in stimulating cell-mediated and mucosal responses, improving protective effects, and modulating the Th1/Th2 balance.

AAPS PHARMSCITECH (2021)

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Article Pharmacology & Pharmacy

Merozoite surface protein 2 adsorbed onto acetalated dextran microparticles for malaria vaccination

Rebeca T. Stiepel et al.

Summary: Increasing the antigen uptake and achieving an antibody and Th1 immune response against malaria infection is crucial. The study found that adsorbing MSP2 antigen onto Ace-DEX microparticles and alum adjuvant both elicited antibody responses in vivo, but only Ace-DEX microparticles were able to elicit a significant Th1-biased response against the intracellular pathogen. MSP2 adsorbed to Ace-DEX microparticles shows promise as a malaria vaccine.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Materials Science, Multidisciplinary

A spontaneously formed and self-adjuvanted hydrogel vaccine triggers strong immune responses

Tao He et al.

Summary: The study developed a spontaneously formed and self-adjuvanted hydrogel (SSH) with enhanced immunogenicity and safety, serving as a new antigen delivery platform with great potential for various immunotherapies.

MATERIALS & DESIGN (2021)

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Article Biotechnology & Applied Microbiology

β-glucans: wide-spectrum immune-balancing food-supplement-based enteric (β-WIFE) vaccine adjuvant approach to COVID-19

Nobunao Ikewaki et al.

Summary: Conventional vaccines against COVID-19 are facing challenges due to the complexity of the virus and uncertainties about immunity duration. Using beta-glucans as an alternative treatment strategy could induce trained immunity and activate mucosal immunity, providing a potential solution until a widely available vaccine is developed.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Materials Science, Biomaterials

Design of Dissolvable Microneedles for Delivery of a Pfs47-Based Malaria Transmission-Blocking Vaccine

Lampouguin Yenkoidiok-Douti et al.

Summary: The study developed and characterized a candidate malaria vaccine based on P47, and loaded and deployed it using microneedle technology. Experimental results confirmed that the malaria vaccine can effectively activate dendritic cells in cell culture, indicating the potential of microneedle technology as an easily deployable strategy for such vaccines.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Environmental Sciences

β-Glucans Could Be Adjuvants for SARS-CoV-2 Virus Vaccines (COVID-19)

Alfredo Cordova-Martinez et al.

Summary: Vaccination is the most effective strategy in the fight against COVID-19, with adjuvants playing a key role in enhancing vaccine efficacy and alleviating symptoms, especially in immunocompromised individuals like the elderly. Glucans, particularly beta-(1,3)-(1,6) glucans, are considered safe and effective adjuvants for boosting immune responses against the SARS-CoV-2 virus.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Allergy

Gelatin-Containing Vaccines for Varicella, Zoster, Measles, Mumps, and Rubella Induce Basophil Activation in Patients with Alpha-Gal Syndrome

Paul Schmidle et al.

Summary: Patients with AGS showed strong positive results for basophil activation tests after vaccination with gelatin-containing vaccines, indicating a high risk for anaphylaxis. BAT is a useful additional tool for screening potentially high-risk alpha-gal-containing drugs.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Alginate-chitosan microcapsules improve vaccine potential of gamma-irradiated Listeria monocytogenes against listeriosis in murine model

Claudia E. Rocha et al.

Summary: In a murine model, encapsulation of gamma-irradiated L. monocytogenes in alginate microcapsules, combined with chitosan, was effective in enhancing immune response against Listeria infection, reducing bacterial loads, and increasing survival rate.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Sarah S. Nasr et al.

Summary: This study investigates the simultaneous delivery of mRNA and pDNA using a single nanocarrier with a thermally stabilized core-shell nanostructure. The experimental results show high transfection efficiency and low cytotoxicity in murine dendritic cell lines, suggesting potential prospects for vaccination and other applications.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Hyaluronic Acid-Glycine-Cholesterol Conjugate-Based Nanoemulsion as a Potent Vaccine Adjuvant for T Cell-Mediated Immunity

Chih-An Lin et al.

Summary: The study demonstrated that the use of hyaluronic acid-glycine cholesterol conjugate as an excipient for vaccine formulation showed promising results by stabilizing the emulsion interface, enhancing immune responses, and reducing local inflammation compared to traditional adjuvants, showcasing its potential in vaccine formulations for boosting T cell-mediated immunity.

PHARMACEUTICS (2021)

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Article Immunology

Mannosylated gelatin nanoparticles enhanced inactivated PRRSV targeting dendritic cells and increased T cell immunity

Jing Huang et al.

Summary: This study evaluated the efficacy of a novel antigen carrier - mannosylated gelatin nanoparticles with inactivated PRRSV in inducing T cell mediated immunity. The results showed that MnGNP efficiently targeted MoDCs, induced maturation, and enhanced T cell activation, proliferation, and cytotoxicity, suggesting its potential as an effective immunization strategy.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2021)

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Article Biotechnology & Applied Microbiology

NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses

Lirong Zhang et al.

Summary: The HA-PDA@IQ/DOX HG is a novel NIR responsive tumor vaccine with high photothermal conversion efficiency and T-1 relaxation efficiency, capable of inducing robust antitumor immune responses through multiple photothermal ablation.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Editorial Material Immunology

Commentary: Beyond TRIM Benefits of β-Glucan by Blood Glucose and Lipid Balancing Potentials in Its Defense Against COVID-19

Nobunao Ikewaki et al.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity

Guangna Liu et al.

Summary: Vaccination has become an effective method to stimulate immunity for disease prevention and treatment, but a tailored efficient delivery system for specific antigens is still urgently needed, especially for vaccines targeting CD8(+) T cells-mediated cellular immunity. Nanotechnology plays a crucial role in enhancing antigen stability and immunogenicity, as well as facilitating APCs-targeted delivery and increased cross-presentation for effective immune protection and clearance.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Developing Acid-Responsive Glyco-Nanoplatform Based Vaccines for Enhanced Cytotoxic T-lymphocyte Responses Against Cancer and SARS-CoV-2

Yanan Gao et al.

Summary: Cytotoxic T-lymphocytes (CTLs) play a central role in protective immunity against malignancies and infectious diseases. This study developed partially oxidized acetalated dextran nanoparticles (Ox-AcDEX NPs) as a general vaccine delivery platform. By conjugating CTL peptide epitopes and immune-enhancing adjuvants, effective vaccines against cancer and viruses were successfully created, demonstrating the potential for immune protection.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

Enhancement of immunopotentiation using tetanus toxoid-based nanoparticulate dissolvable microneedles

Mansi Waghchaure et al.

Summary: The study aimed to prepare and evaluate dissolvable microneedle patches containing tetanus toxoid nanoparticles without adjuvant, using a layer-by-layer coating method. It was found that aminated gelatin nanoparticles had the highest entrapment efficiency. The study also demonstrated that aminated nanoparticulate microneedles had the highest antibody production against tetanus toxoid, suggesting their potential as an alternative method for tetanus toxoid delivery.

BIOMEDICAL MICRODEVICES (2021)

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Article Chemistry, Applied

Recent advances in dextran-based drug delivery systems: From fabrication strategies to applications

Qiaobin Hu et al.

Summary: Dextran and its derivatives have attracted significant attention in the development of delivery systems for pharmaceutical and medical applications. Various dextran-based delivery systems have been developed with tailored properties and geometries, showing potential for diverse biomedical applications. Research focuses on the physicochemical properties of dextran, fabrication strategies, and their applications in biomedicine.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

Hydroxypropyltrimethyl ammonium chloride chitosan-based hydrogel as the split H5N1 mucosal adjuvant: Structure-activity relationship

Qingze Fan et al.

Summary: The study developed HTCC-based hydrogel as a mucosal adjuvant for H5N1 vaccine, and found that with increasing DQ, the positive charge and gelation time of HTCC hydrogel increased while viscosity decreased. Results showed that HTCC hydrogel with a DQ of 41% prolonged antigen residence time in nasal cavity, resulting in the most potent systemic immune responses.

CARBOHYDRATE POLYMERS (2021)

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Article Pharmacology & Pharmacy

Novel ablative laser mediated transdermal immunization for microparticulate measles vaccine

Devyani Joshi et al.

Summary: This study aimed to develop microparticulate formulation of measles vaccine and explore transdermal delivery via ablative laser mediated skin microporation, showing that transdermal immunization is as efficient as traditional subcutaneous administration.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2

Salma N. Tammam et al.

Summary: The COVID-19 pandemic caused by SARSCoV2 has led to a global health crisis. Drug repurposing has emerged as a frontline strategy in the battle against the virus, with inhalation therapy using nanomedicine reformulation showing promise in providing stronger, more localized action with reduced adverse effects. This approach could address limitations of current therapeutics and be crucial in the fight against current and future outbreaks.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus

Yaling Wang et al.

Summary: The new nanovaccine containing RBD and MnARK shows stronger neutralizing abilities against infection compared to the Alum-adsorbed RBD vaccine. The co-delivery of RBD antigen and MnARK to lymph nodes promotes cellular internalization and the activation of immune cells.

NANO TODAY (2021)

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Review Cell & Tissue Engineering

Mucosal Vaccine Delivery Using Mucoadhesive Polymer Particulate Systems

Chong-Su Cho et al.

Summary: Vaccination is considered as one of the most successful medical treatments to prevent the prevalence of infectious diseases. Mucosal vaccination is of interest due to its role in the first line of defense against pathogens. Developing efficient antigen delivery systems for mucosal vaccination is crucial to stimulate mucosal and systemic immunity.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Article Multidisciplinary Sciences

Optimizing ethyl cellulose-ethanol delivery towards enabling ablation of cervical dysplasia

Jenna L. Mueller et al.

Summary: This study describes a low-cost, portable treatment for cervical dysplasia in low-income countries, using injection of ethyl cellulose-ethanol to ablate the transformation zone around the cervix. Experimental results show that specific injection parameters can achieve the desired therapeutic effect.

SCIENTIFIC REPORTS (2021)

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Review Polymer Science

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Sindi P. Ndlovu et al.

Summary: Wound care is a challenging field due to delayed wound healing process caused by various factors. Biopolymer-based wound dressings show promising properties such as good biocompatibility and antimicrobial activity, but they often lack mechanical strength. Gelatin, a biopolymer with excellent biocompatibility, can be improved by crosslinking with other polymers and incorporating antimicrobial agents for enhanced antimicrobial activity.

POLYMERS (2021)

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Article Materials Science, Biomaterials

Inducing Immunomodulatory Effects on Human Macrophages by Multifunctional NCO-sP(EO-stat-PO)/Gelatin Hydrogel Nanofibers

Mehmet Berat Taskin et al.

Summary: The study reported a novel scaffold material made of gelatin and six-arm star-shaped prepolymer, showing immunomodulatory properties and promoting cell adhesion while also regulating gene expression and reducing inflammation. Additionally, covalent conjugation of IL-4 effectively directed macrophages towards a pro-healing M2 phenotype, demonstrating robust control over the immunomodulatory feature of the scaffolds.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Immunology

Nasal Epithelial Barrier Integrity and Tight Junctions Disruption in Allergic Rhinitis: Overview and Pathogenic Insights

Siti Muhamad Nur Husna et al.

Summary: Allergic rhinitis is a common disorder affecting up to 40% of the global population, characterized by impaired nasal epithelial barrier and crucial involvement of TJ molecules in its pathogenesis. Various regulatory factors have been identified, offering hope for the development of novel therapeutic approaches.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

The Prognostic Value of CD206 in Solid Malignancies: A Systematic Review and Meta-Analysis

Jens M. Debacker et al.

Summary: This study found that in patients with solid cancers, the presence of CD206-expressing TAMs can serve as a significant negative prognostic biomarker. However, there is a large heterogeneity in the results among different tumor types. Further research is needed to validate the specific prognostic value of CD206 in individual tumor types and therapeutic approaches.

CANCERS (2021)

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Article Nanoscience & Nanotechnology

Robust Immune Responses Elicited by a Hybrid Adjuvant Based on β-Glucan Particles from Yeast for the Hepatitis B Vaccine

Hui Liu et al.

Summary: The study developed an antigen delivery system combining aluminum salts with beta-glucan particles, which showed promising results in enhancing hepatitis B vaccine-induced immune responses in vivo.

ACS APPLIED BIO MATERIALS (2021)

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Proceedings Paper Materials Science, Multidisciplinary

A review of gelatin: Properties, sources, process, applications, and commercialisation

J. Alipal et al.

Summary: This paper primarily discusses the properties, sources, and market status of gelatin, analyzing the commercialization process and traditional production methods and modern processing methods. It also mentions the impact of plant alternatives on the gelatin market, as well as recent research on market trends.

MATERIALS TODAY-PROCEEDINGS (2021)

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Article Oncology

The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia

Zi-Jun Xu et al.

ONCOIMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Recent Advances in Chain Conformation and Bioactivities of Triple-Helix Polysaccharides

Yan Meng et al.

BIOMACROMOLECULES (2020)

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Editorial Material Immunology

Training the trainable cells of the immune system and beyond

Upendra K. Kar et al.

NATURE IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Supramolecular Prodrug Nanovectors for Active Tumor Targeting and Combination Immunotherapy of Colorectal Cancer

Xianli Hu et al.

ADVANCED SCIENCE (2020)

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Article Medicine, General & Internal

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

Eun Kim et al.

EBIOMEDICINE (2020)

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Article Pharmacology & Pharmacy

A novel concept for treatment and vaccination against Covid-19 with an inhaled chitosan-coated DNA vaccine encoding a secreted spike protein portion

Dean Tatlow et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

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Article Oncology

Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification

Chengbiao Chu et al.

CANCERS (2020)

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Article Chemistry, Multidisciplinary

Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity

Gillie A. Roth et al.

ACS CENTRAL SCIENCE (2020)

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Article Immunology

Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8+ T Cells That Are Protective against Influenza Virus Infection

James G. Bedford et al.

VACCINES (2020)

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Article Pharmacology & Pharmacy

Laser-assisted skin delivery of immunocontraceptive rabies nanoparticulate vaccine in poloxamer gel

Amit Bansal et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Biology

Adjuvant potency of Astragaloside VII embedded cholesterol nanoparticles for H3N2 influenza vaccine

Rukan Genc et al.

TURKISH JOURNAL OF BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Polysaccharides against Viruses: Immunostimulatory Properties and the Delivery of Antiviral Vaccines and Drugs

Guy-Alain Junter et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Pharmacology & Pharmacy

Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization

Jafar Mosafer et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Gambogic acid-encapsulated polymeric micelles improved therapeutic effects on pancreatic cancer

Yan Wang et al.

CHINESE CHEMICAL LETTERS (2019)

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Article Biochemistry & Molecular Biology

Polymeric nanoengineered HBsAg DNA vaccine designed in combination with β-glucan

Edna Soares et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

Hyaluronic Acid Nanocapsules as a Platform for Needle-Free Vaccination

Juan Bussio et al.

PHARMACEUTICS (2019)

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Review Biochemistry & Molecular Biology

Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic

Anne Geller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Multilamellar Vaccine Particle Elicits Potent Immune Activation with Protein Antigens and Protects Mice against Ebola Virus Infection

Yuchen Fan et al.

ACS NANO (2019)

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Article Polymer Science

Design and Characterization of Surface-Crosslinked Gelatin Nanoparticles for the Delivery of Hydrophilic Macromolecular Drugs

Abdul Baseer et al.

MACROMOLECULAR CHEMISTRY AND PHYSICS (2019)

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Article Chemistry, Multidisciplinary

The Crystallinity and Aspect Ratio of Cellulose Nanomaterials Determine Their Pro-Inflammatory and Immune Adjuvant Effects In Vitro and In Vivo

Xiang Wang et al.

SMALL (2019)

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Article Biochemical Research Methods

Cross-Protective Abilities of Hyaluronic Acid Modified with Tetraglycine-L-octaarginine as a Mucosal Adjuvant against Infection with Heterologous Influenza Viruses

Sohei Tanishita et al.

BIOCONJUGATE CHEMISTRY (2019)

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Article Chemistry, Physical

Alginate-chitosan coated layered double hydroxide nanocomposites for enhanced oral vaccine delivery

Xinying Yu et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Enhanced paracellular delivery of vaccine by hydrogel microparticles-mediated reversible tight junction opening for effective oral immunization

Xiang Yi Chen et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Engineering, Biomedical

Surface assembly of poly(I:C) on polyethyleneimine-modified gelatin nanoparticles as immunostimulatory carriers for mucosal antigen delivery

Shen-Fu Lin et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2019)

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Review Immunology

Causal relationship between immunological responses and adverse reactions following vaccination

Tetsuo Nakayama

VACCINE (2019)

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Article Chemistry, Multidisciplinary

β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

Hanxuan Wang et al.

CHEMICAL COMMUNICATIONS (2019)

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Review Pharmacology & Pharmacy

Recent Approaches for Solid Dose Vaccine Delivery

Nishat Jahan et al.

SCIENTIA PHARMACEUTICA (2019)

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Article Cell & Tissue Engineering

Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles

Ho-Bin Lee et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Cell & Tissue Engineering

Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles

Ho-Bin Lee et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Biochemical Research Methods

Protein Enables Conformation Transition of a Hydrogel Based on Pentapeptide and Boosts Immune Response in Vivo

Yune Zhao et al.

BIOCONJUGATE CHEMISTRY (2018)

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Article Pharmacology & Pharmacy

Characterization of rabies pDNA nanoparticulate vaccine in poloxamer 407 gel

Amit Bansal et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Pharmacology & Pharmacy

Development of orally-deliverable DNA hydrogel by microemulsification and chitosan coating

Daiki Nomura et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

Tunable degradation of acetalated dextran microparticles enables controlled vaccine adjuvant and antigen delivery to modulate adaptive immune responses

Naihan Chen et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

Neha N. Parayath et al.

NANO LETTERS (2018)

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Review Polymer Science

Polymer-Based Nanomaterials and Applications for Vaccines and Drugs

Jinyu Han et al.

POLYMERS (2018)

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Article Biotechnology & Applied Microbiology

Microcrystalline Cellulose for Delivery of Recombinant Protein-Based Antigen against Erysipelas in Mice

Wooyoung Jeon et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Article Medicine, Research & Experimental

Bovine serum albumin nanoparticles induce histopathological changes and inflammatory cell recruitment in the skin of treated mice

Natalia Ingrid Oliveira da Silva et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Chemistry, Multidisciplinary

Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy

Naihan Chen et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Immunology

Serum albumin nanoparticles vaccine provides protection against a lethal Pseudomonas aeruginosa challenge

Stella Maria de Souza Morais et al.

VACCINE (2018)

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Review Polymer Science

Oral Vaccine Delivery for Intestinal Immunity-Biological Basis, Barriers, Delivery System, and M Cell Targeting

Sung Hun Kang et al.

POLYMERS (2018)

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Article Medicine, Research & Experimental

Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists

Michael A. Collier et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Polymer Science

Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules

Aaron Alford et al.

POLYMERS (2018)

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Article Pharmacology & Pharmacy

Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan

Yumiko Ishii-Mizuno et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant

Ting Yan et al.

NANOMATERIALS (2017)

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Article Nanoscience & Nanotechnology

Nanoparticle Targeting CD44-Positive Cancer Cells for Site-Specific Drug Delivery in Prostate Cancer Therapy

Wen-Ying Huang et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Review Microbiology

Malaria vaccines and human immune responses

Carole A. Long et al.

CURRENT OPINION IN MICROBIOLOGY (2016)

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Article Biotechnology & Applied Microbiology

Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses

Simon H. Apte et al.

NANOMEDICINE (2016)

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Meeting Abstract Nanoscience & Nanotechnology

Cellulose-based oral vaccine formulation for influenza virus

Hezhong Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Article Thermodynamics

New functional Fe3O4 nanoparticles utilizing as adjuvant in the green PVA/cellulose whiskers nanocomposite

Mehdi Roohani et al.

THERMOCHIMICA ACTA (2016)

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Article Immunology

Vaccine impact: Benefits for human health

Mark Doherty et al.

VACCINE (2016)

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Article Virology

Immunogenicity of porcine circovirus type 2 nucleic acid vaccine containing CpG motif for mice

Jun Li et al.

VIROLOGY JOURNAL (2016)

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Article Engineering, Biomedical

Therapeutic intradermal delivery of tumor necrosis factor-alpha antibodies using tip-loaded dissolvable microneedle arrays

Emrullah Korkmaz et al.

ACTA BIOMATERIALIA (2015)

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Article Engineering, Biomedical

Attuning hydroxypropyl methylcellulose phthalate to oral delivery vehicle for effective and selective delivery of protein vaccine in ileum

Bijay Singh et al.

BIOMATERIALS (2015)

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Article Chemistry, Applied

Development and characterization of alginate coated low molecular weight chitosan nanoparticles as new carriers for oral vaccine delivery in mice

Subrata Biswas et al.

CARBOHYDRATE POLYMERS (2015)

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Review Immunology

New approaches to HIV vaccine development

Barton F. Haynes

CURRENT OPINION IN IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Recent advancement of gelatin nanoparticles in drug and vaccine delivery

Nityananda Sahoo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Immunology

Preclinical development of a dengue tetravalent recombinant subunit vaccine: Immunogenicity and protective efficacy in nonhuman primates

Dhanasekaran Govindarajan et al.

VACCINE (2015)

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Review Immunology

The march toward malaria vaccines

Stephen L. Hoffman et al.

VACCINE (2015)

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Article Engineering, Biomedical

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

Catia S. Verbeke et al.

ADVANCED HEALTHCARE MATERIALS (2015)

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Article Cell & Tissue Engineering

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target

Yongmin Yan et al.

STEM CELLS TRANSLATIONAL MEDICINE (2015)

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Review Immunology

Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics

Kine Marita Knudsen Sand et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Chemistry, Multidisciplinary

Dissolvable Microneedle Arrays for Intradermal Delivery of Biologics: Fabrication and Application

Bekir Bediz et al.

PHARMACEUTICAL RESEARCH (2014)

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Article Materials Science, Biomaterials

Cellulose-based polyelectrolyte complex nanoparticles for DNA vaccine delivery

Yongbo Song et al.

BIOMATERIALS SCIENCE (2014)

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Article Polymer Science

Chitosan-based biomaterials for tissue engineering

Florence Croisier et al.

EUROPEAN POLYMER JOURNAL (2013)

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Article Allergy

Adverse reactions to vaccines practice parameter 2012 update

John M. Kelso et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Review Pharmacology & Pharmacy

Recent trends in vaccine delivery systems: A review

C. H. Saroja et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION (2011)

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Article Pediatrics

Prevalence of anti-gelatin IgE antibodies in people with anaphylaxis after measles-mumps-rubella vaccine in the United States

V Pool et al.

PEDIATRICS (2002)

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Article Immunology

Anaphylactic reaction to diphtheria-tetanus vaccine in a child:: specific IgE/IgG determinations and cross-reactivity studies

MF Martín-Muñoz et al.

VACCINE (2002)

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