期刊
GELS
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/gels9030227
关键词
natural polymer; vaccine delivery; adjuvant; plant; animal; microbe
A key challenge in vaccine delivery is the poor immunogenicity and adverse inflammatory reactions. Various delivery methods, including natural-polymer-based carriers, have been used to improve immune response. Incorporating adjuvants or antigens into biomaterial-based immunizations enables better immune response. This review focuses on the recent applications of natural polymer composites in vaccine delivery systems.
A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.
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