☆ 4.7 Review

Recent Advances in Stimuli-Responsive Hydrogel-Based Wound Dressing

GELS (2023)

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Article Polymer Science

Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration

Patricia C. Pires et al.

Summary: The increasing emergence of skin diseases and the difficulty in treating damaged skin using conventional therapies have called for the development of novel drug delivery systems utilizing natural polymers. These natural polymers offer advantages such as biocompatibility, biodegradability, economic feasibility, and inherent bioactive properties. This review examines the latest drug delivery system technologies using natural polymers and discusses their in vitro, ex vivo, and in vivo experiments. Additionally, it highlights the therapeutic capabilities of biopolymer-based nanoparticles for various skin conditions.

EUROPEAN POLYMER JOURNAL (2023)

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Article Food Science & Technology

Stimulus-responsive hydrogels: A potent tool for biosensing in food safety

Xiaoxiao Lin et al.

Summary: Stimulus-responsive hydrogels are three-dimensional network structure gels with extreme hydrophilic properties and can respond to changes in the environment. They have wide applications and great potential in the development of intelligent hydrogels, especially in the field of food safety. By discussing their various application types, the advantages and characteristics of stimulus-responsive hydrogels were analyzed, and their potentials in intelligent food detection systems were explored.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2023)

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Article Engineering, Biomedical

Recent advances in responsive hydrogels for diabetic wound healing

Siming Zhang et al.

Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.

MATERIALS TODAY BIO (2023)

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Article Engineering, Biomedical

Glucose-Responsive Antioxidant Hydrogel Accelerates Diabetic Wound Healing

Fang Chen et al.

Summary: This study introduces reversible boronic bonds to create an intelligent antioxidant hydrogel scaffold for efficient delivery of antioxidants to diabetic wounds. The hydrogel responds to changes in glucose levels, releasing more antioxidants as glucose level increases. The hydrogel shows good biocompatibility, biodegradability, and mechanical properties similar to skin tissue. In vitro and in vivo experiments demonstrate that the hydrogel effectively eliminates reactive oxygen species, reduces inflammation, promotes angiogenesis, and improves tissue remodeling during diabetic wound healing. This strategy offers new insight into glucose-responsive scaffolds and holds great potential for the treatment of chronic diabetic wounds.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Materials Science, Multidisciplinary

A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing

Chunyang Li et al.

Summary: During wound healing, the synergistic effect of providing continuous and controllable oxygen while inhibiting inflammation is crucial. In this study, a photothermal response-assisted strategy was developed using a composite hydrogel system loaded with nanoparticles that showed excellent photothermal performance. This system enables controllable and sustainable oxygen release and can effectively inhibit inflammation, offering a new approach for treating chronic wounds.

NPG ASIA MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Novel Glucose-Responsive Antioxidant Hybrid Hydrogel for Enhanced Diabetic Wound Repair

Zejun Xu et al.

Summary: In this study, a novel glucose-responsive antioxidant hybrid hydrogel was designed and prepared for enhanced diabetic wound repair. The hydrogel achieved glucose-triggered antioxidant substance release and efficient reactive oxygen species scavenging, leading to improved inflammatory response, accelerated angiogenesis, and promoted diabetic wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Engineering, Biomedical

Topical gel-based biomaterials for the treatment of diabetic foot ulcers

James R. Bardill et al.

Summary: Diabetic foot ulcers are a serious and common problem, and standard wound care treatments have limited efficacy. The development of novel topical biomaterial gels has the potential to improve therapeutic effects. This review summarizes the research and advances in this field.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Ye Wu et al.

Summary: The injectable glycopeptide hydrogel fabricated in this study possesses multifunctionality, including inherent antibacterial and antioxidant capabilities, as well as the ability to promote angiogenesis and accelerate wound healing. The spatiotemporal delivery of therapeutic agents within the hydrogel allows for effective anti-infection, anti-oxidation, and anti-inflammation effects, making it a promising strategy for treating chronic diabetic wounds.

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Article Materials Science, Biomaterials

pH responsive release of curcumin from photocrosslinked pectin/gelatin hydrogel wound dressings

Nazli Seray Bostanci et al.

Summary: This study developed hydrogel wound dressings with antimicrobial properties, controlling the release of curcumin by altering the formulation and medium pH. The P1:G3 hydrogels demonstrated high stability and antibacterial efficacy, showing potential as wound dressing materials for treating infected and chronic wounds.

BIOMATERIALS ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Xin Yang et al.

Summary: A novel MXene-based hydrogel drug delivery system for efficient treatment of deep chronic wounds is introduced in the study. This system demonstrates multiple response capability and controllable drug delivery ability, reducing toxic side effects of drugs and promoting wound healing process. The practical performance of the system in treating rat models indicates great prospect in clinical wound healing and related biomedical fields.

SMALL (2022)

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Health economics of diabetic foot ulcer and recent trends to accelerate treatment

Abha Jodheea-Jutton et al.

Foot (2022)

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Article Engineering, Biomedical

Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair

Zejun Xu et al.

Summary: In this study, a glucose-responsive HA-based hydrogel platform was developed for rapid repair of diabetic wounds. The HMPC hydrogel effectively promoted angiogenesis and reduced inflammatory response, leading to the rapid recovery of diabetic wounds.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Glucose-responsive multifunctional metal-organic drug-loaded hydrogel for diabetic wound healing

Jiaxin Yang et al.

Summary: In this study, a glucose-responsive multifunctional metal-organic drug-loaded hydrogel (DG@Gel) was designed for diabetic wound healing. The hydrogel changed the hyperglycemic wound microenvironment, exhibited antibacterial and angiogenic activity, and showed good biocompatibility and biodegradability in vivo.

ACTA BIOMATERIALIA (2022)

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Review Biochemistry & Molecular Biology

Progress in Hydrogels for Skin Wound Repair

Liangfa Qi et al.

Summary: As the first line of defense against the outside world, the skin is susceptible to damage, resulting in acute or chronic wounds. Various wound dressings have been developed to manage skin wounds, and hydrogels have gained significant attention due to their biomimetic structure and bioactive substance delivery capability. This paper introduces the anatomy and function of the skin, the process of wound healing, and the composition and construction methods of hydrogels. It also discusses the importance of hydrogels in skin wound repair and presents the latest research progress, as well as future development goals.

MACROMOLECULAR BIOSCIENCE (2022)

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Article Chemistry, Physical

A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound repair

Zejun Xu et al.

Summary: A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity has been developed for enhanced diabetic wound repair. The hydrogel platform shows remarkable biocompatibility and antioxidant properties, as well as the ability to regulate blood glucose levels, promote angiogenesis, and effectively treat inflammation.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Micro-Gel Ensembles for Accelerated Healing of Chronic Wound via pH Regulation

Tingting Cui et al.

Summary: This work presents a microfluidic assembly technique to fabricate micro-gel ensembles that can precisely tune the pH value of wound surface and accelerate wound healing. By regulating the wound pH, the physiological processes are greatly facilitated, resulting in much accelerated healing of chronic wounds.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation

Bingyang Lu et al.

Summary: Chronic wounds and inflammation are challenges in clinical treatment. Research has found that using new hydrogels can effectively treat and regulate the inflammatory microenvironment of chronic wounds, promoting wound repair.

MATERIALS TODAY BIO (2022)

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Review Pharmacology & Pharmacy

Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review

Bruno Vincenzo Fiod Riccio et al.

Summary: Polymeric films are drug delivery systems that maintain contact with the target tissue and control the release of therapeutic molecules. They can be manufactured using various methods and polymers and can be administered through different routes. This review explores the development, advantages and disadvantages of polymeric films, highlighting their versatility.

AAPS PHARMSCITECH (2022)

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Review Medicine, Research & Experimental

Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance

Abdul Q. Khan et al.

Summary: This review highlights the recent advances in understanding the pathogenesis and therapeutic developments of cutaneous inflammatory diseases, with a focus on the crucial role of oxidative stress in diseases like atopic dermatitis and psoriasis. Additionally, the clinical importance of natural products for managing skin diseases is explored.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Polymer Science

pH-sensitive release of antioxidant Se-glycoconjugates through a flexible polymeric patch

Luigia Serpico et al.

Summary: In this study, two novel selenium glycoconjugates were developed as antioxidants for skin repair acceleration. These conjugates are capable of pH-sensitive release, making them a promising candidate for wound care practices.

EUROPEAN POLYMER JOURNAL (2022)

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Article Chemistry, Physical

Preparation of ROS-responsive drug-loaded hydrogels applied in wound dressings using supercritical solvent impregnation

Jin-Zhou Rui et al.

Summary: This study applied drug-loaded hydrogels with wound environment stimuli-responsive property in dressings, providing a new approach for designing composite hydrogel formulations with uniform drug distribution.

JOURNAL OF SUPERCRITICAL FLUIDS (2022)

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Article Engineering, Biomedical

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

Lin Jin et al.

Summary: This study developed a band-aid with a core-shell structure to modulate vascularization and the immune microenvironment, leading to scarless wound healing. The band-aid released H2S and a growth factor, which controlled macrophage polarization and inhibited excessive inflammation, thereby promoting skin cell proliferation and facilitating wound healing.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Applied

Dual light-responsive cellulose nanofibril-based in situ hydrogel for drug-resistant bacteria infected wound healing

Xiaokun Shi et al.

Summary: A novel wound dressing with rapid hemostasis and antibacterial activity has been developed, which can achieve dual response through white light and NIR irradiation. The dressing exhibits excellent biocompatibility and has promising applications in first-aid hemostasis and wound healing.

CARBOHYDRATE POLYMERS (2022)

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Article Polymer Science

Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications

Zubair Ahmad et al.

Summary: This review discusses the importance and applications of hydrogels in the field of biomedicine, including synthetic strategies, characterization, and various application areas. It provides guidance for tracking, designing, and using hydrogels.

GELS (2022)

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Article Polymer Science

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Hai Xin et al.

Summary: Breast cancer is a major health threat for women, and there is a need for novel therapies to overcome the limitations of conventional treatments. Injectable hydrogels as drug delivery systems have gained attention recently for their potential to improve treatment efficacy and reduce side effects by providing localized and controlled drug release at the tumor site.

GELS (2022)

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Article Endocrinology & Metabolism

Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice

Ya Li et al.

Summary: Hyperglycemia reduces NAD(+) biosynthesis in the cornea, leading to impaired epithelial wound healing in diabetic mice and patients. Replenishment of NAD(+) and its precursors can facilitate corneal wound healing and nerve regeneration in diabetic conditions, suggesting a novel therapeutic strategy for diabetic corneal complications.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Engineering, Biomedical

A Hydrogen-Bonded Extracellular Matrix-Mimicking Bactericidal Hydrogel with Radical Scavenging and Hemostatic Function for pH-Responsive Wound Healing Acceleration

Zainab Ahmadian et al.

Summary: The multifunctional GelTA hydrogel is fabricated through abundant hydrogen bonding among the functional groups of gelatin and tannic acid, showing adjustable physicochemical properties and high safety features. It accelerates wound healing through pH-dependent release of active agents, promotes extracellular matrix formation and wound closure by offering cell adhesion sites, and is a promising candidate for clinical treatment of full-thickness wounds.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Aziz Maleki et al.

Summary: Light-based photothermal therapy (PTT) and photo-dynamic therapy (PDT) have great potential in wound healing and infection prevention. Multifunctional photoresponsive hydrogels (MPRHs) combining light and hydrogel advantages are increasingly used in biomedicine, particularly in wound repair. The modulation of bacterial microenvironments to inhibit infection through PTT, PDT, and photothermal/photodynamic synergistic therapy has been discussed.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Smart wound dressings for wound healing

Ruonan Dong et al.

Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.

NANO TODAY (2021)

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Article Materials Science, Biomaterials

Preparation of a recombinant collagen-peptide (RHC)-conjugated chitosan thermosensitive hydrogel for wound healing

Aipeng Deng et al.

Summary: Thermoresponsive hydrogels formed by conjugating recombinant human collagen-peptide (RHC) with chitosan exhibit lower gelation temperature and superior mechanical strength, showing good biocompatibility with cells and promoting cell infiltration, vessel formation, and wound healing. Overall, the use of RHC-chitosan hydrogels is a promising and effective therapeutic approach for burn wound treatment.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Endocrinology & Metabolism

Skin Metabolomics

Decibel P. Elpa et al.

Summary: The skin retains a variety of metabolites that play important physiological roles and can be detected to diagnose and treat diseases. Miniature probes have been developed to detect high-abundance metabolites secreted with sweat, and analysis methods such as chromatography and mass spectrometry are used to study a broad spectrum of skin metabolites.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Article Medical Laboratory Technology

Cutaneous innervation in impaired diabetic wound healing

Nicole C. Nowak et al.

Summary: Type 2 diabetes is associated with complications such as impaired wound healing, chronic ulcers, and the need for amputation. The role of nerves in wound healing in diabetic patients is not fully understood, but studying these mechanisms may lead to targeted treatments for chronic diabetic wounds.

TRANSLATIONAL RESEARCH (2021)

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Review Oncology

Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field

Fernanda Andrade et al.

Summary: Cancer remains the second leading cause of death globally, with the major obstacles in treatment being chemotherapy side effects and drug resistance. Research is ongoing to develop new formulations for localized drug delivery at tumor sites to improve treatment outcomes. Stimuli-responsive hydrogels, such as pH-, light-, ionic strength-, and magnetic-responsive hydrogels, show promising results in the localized control and treatment of cancer.

CANCERS (2021)

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Article Engineering, Biomedical

Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering

Ting Su et al.

Summary: The study focused on the facile fabrication and optimization of agarose-polydopamine hydrogel (APG) scaffolds for skin wound healing, showing improved mechanical properties and cell adhesiveness with the addition of polydopamine. The highest polydopamine content scaffold promoted full-thickness skin defect healing by accelerating collagen deposition and promoting angiogenesis, demonstrating clinical translation potentials.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Applied

Dual-crosslinked, self-healing and thermo-responsive methylcellulose/chitosan oligomer copolymer hydrogels

Yong Ho Yeo et al.

Summary: Self-healing, thermo-responsive hydrogels have been developed using methylcellulose (MC) and a water-soluble chitosan oligomer (CHI-O) through dual-crosslinking. The copolymer hydrogels exhibited superior gelation rate, mechanical properties, and self-healing capabilities compared to MC hydrogels, making them suitable for cosmetic applications. Release studies of model compounds from the DAMC/CHI-O copolymer hydrogel showed promise for future applications.

CARBOHYDRATE POLYMERS (2021)

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Article Engineering, Environmental

Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Cheng Hu et al.

Summary: The study successfully overcame the challenges in healing chronic diabetic wounds, such as bacterial infections and difficulty in angiogenesis, by using a pH-responsive double-crosslinking hydrogel.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Pharmacology & Pharmacy

Stimuli-responsive hydrogels for intratumoral drug delivery

Ana C. Marques et al.

Summary: This article provides an overview of using hydrogels for drug delivery, highlighting the advantages of intratumoral administration by endowing hydrogels with responsiveness to different stimuli.

DRUG DISCOVERY TODAY (2021)

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Article Materials Science, Multidisciplinary

pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

Zuhao Li et al.

Summary: A self-healing, injectable, and pH responsive hydrogel was successfully synthesized and incorporated with insulin glargine, showing promising potential in accelerating the healing of diabetic foot ulcers by shortening the inflammatory phase, promoting tissue formation, and improving treatment outcomes.

MATERIALS & DESIGN (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Article Cell Biology

Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments

Rou Wan et al.

Summary: Diabetes is a systemic disease that affects the body's ability to regulate blood sugar levels, leading to complications such as chronic non-healing wounds, which can significantly impact patients' quality of life. Scientific studies have shown that high glucose levels can interfere with fibroblast differentiation and myofibroblast function, affecting extracellular matrix production and wound contraction. Further research on potential treatments targeting these pathways is essential for improving wound healing in diabetic patients.

WOUND REPAIR AND REGENERATION (2021)

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Article Pharmacology & Pharmacy

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

Cheng Yang et al.

Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Stimuli-responsive hydrogel microcapsules for the amplified detection of microRNAs

Wen-Hsin Chang et al.

Summary: A method for synthesizing DNA-based acrylamide hydrogel microcapsules loaded with quantum dots as readout signal is introduced, which can detect cancer-associated microRNAs. The detection sensitivity can be improved by coupling the microcapsules with strand displacement amplification.

NANOSCALE (2021)

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Review Chemistry, Multidisciplinary

Multi-stimuli-responsive hydrogels and their medical applications

Ali Pourjavadi et al.

Summary: Multi-stimuli-responsive hydrogels have gained increased attention for their tunable changes in swelling or mechanical properties in physiological states. They are widely used in medical applications, with a focus on self-healing hydrogels, anti-bacterial materials, and drug-delivery systems.

NEW JOURNAL OF CHEMISTRY (2021)

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Review Engineering, Biomedical

Recent advances on polymeric hydrogels as wound dressings

Zheng Pan et al.

Summary: Hydrogels are attracting intensive attention for their high porosity, good biocompatibility, and beneficial properties for wound healing. Traditional hemostasis methods have limitations, while hydrogel dressings offer more advantages. Future research and development should focus on overcoming the challenges of hydrogel dressings and improving their performance and applications.

APL BIOENGINEERING (2021)

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Article Chemistry, Multidisciplinary

Progress in natural polymer engineered biomaterials for transdermal drug delivery systems

V. S. Sivasankarapillai et al.

Summary: Research focuses on the development of transdermal drug delivery systems, as well as the application of important biopolymers in this field. The advantages and limitations of topical drug delivery methods, as well as three common biopolymers such as natural rubber, chitosan, and cellulose, are extensively analyzed.

MATERIALS TODAY CHEMISTRY (2021)

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Review Chemistry, Applied

Carbohydrate polymer-based silver nanocomposites: Recent progress in the antimicrobial wound dressings

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CARBOHYDRATE POLYMERS (2020)

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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Preparation of reactive oxygen species-responsive antibacterial hydrogels for efficient anti-infection therapy

Jingxuan Hu et al.

MATERIALS LETTERS (2020)

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Article Chemistry, Applied

Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing

Mengsi Ma et al.

CARBOHYDRATE POLYMERS (2020)

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Italo Rodrigo Calori et al.

EUROPEAN POLYMER JOURNAL (2020)

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Yu Chen

CURRENT MEDICINAL CHEMISTRY (2020)

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Natural Polymer-Based Antimicrobial Hydrogels without Synthetic Antibiotics as Wound Dressings

Yajie Zhong et al.

BIOMACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Double crosslinked HLC-CCS hydrogel tissue engineering scaffold for skin wound healing

Jing Cao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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ADVANCED SCIENCE (2020)

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Review Biochemistry & Molecular Biology

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Shima Tavakoli et al.

BIOMOLECULES (2020)

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Article Multidisciplinary Sciences

Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

Andrew P. Sawaya et al.

NATURE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Wound healing: cellular mechanisms and pathological outcomes

Holly N. Wilkinson et al.

OPEN BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Thermo-responsive chitosan hydrogel for healing of full-thickness wounds infected with XDR bacteria isolated from burn patients: In vitro and in vivo animal model

Zahra Aliakbar Ahovan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Chemistry, Medicinal

The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

Simona Federica Spampinato et al.

PHARMACEUTICALS (2020)

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Article Engineering, Biomedical

ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds

He Zhao et al.

BIOMATERIALS (2020)

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Yong Kiel Sung et al.

BIOMATERIALS RESEARCH (2020)

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Article Materials Science, Biomaterials

A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion

Na Yang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Smart wound dressing for infection monitoring and NIR-triggered antibacterial treatment

Bianbian Qiao et al.

BIOMATERIALS SCIENCE (2020)

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Article Business

Investigating the emerging COVID-19 research trends in the field of business and management: A bibliometric analysis approach

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JOURNAL OF BUSINESS RESEARCH (2020)

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Article Materials Science, Biomaterials

In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing

Huiyan Ying et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

Satish Patel et al.

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Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles

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Reversible Thermoresponsive Peptide-PNIPAM Hydrogels for Controlled Drug Delivery

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BIOMACROMOLECULES (2019)

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Thermoresponsive in Situ Forming Hydrogel with Sol-Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing

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Hydrogel wound dressings for bioactive treatment of acute and chronic wounds

Julia Koehler et al.

EUROPEAN POLYMER JOURNAL (2018)

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Article Chemistry, Multidisciplinary

Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly (propylene sulfide) scaffolds loaded with poorly water-soluble drugs

Suwei Zhu et al.

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Article Multidisciplinary Sciences

Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing

Xin Zhao et al.

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Hydrogels for Atopic Dermatitis and Wound Management: A Superior Drug Delivery Vehicle

Ian P. Harrison et al.

PHARMACEUTICS (2018)

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Review Biochemistry & Molecular Biology

Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

Mariola Cano Sanchez et al.

ANTIOXIDANTS (2018)

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Article Dermatology

Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process

Christopher Dunnill et al.

INTERNATIONAL WOUND JOURNAL (2017)

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Review Pharmacology & Pharmacy

Cell based therapeutics in type 1 diabetes mellitus

Fernanda Zamboni et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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