Polymeric DNA Hydrogels and Their Applications in Drug Delivery for Cancer Therapy

The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. DNA hydrogels, composed of three-dimensional networks of DNA chains, have received considerable attention as a promising biomaterial due to their good biocompatibility and biodegradability. DNA hydrogels with specific functions can be prepared via assembly of various functional sequences containing DNA modules. In recent years, DNA hydrogels have been widely used for drug delivery, particularly in cancer therapy. Benefiting from the sequence programmability and molecular recognition ability of DNA molecules, DNA hydrogels prepared using functional DNA modules can achieve efficient loading of anti-cancer drugs and integration of specific DNA sequences with cancer therapeutic effects, thus achieving targeted drug delivery and controlled drug release, which are conducive to cancer therapy. In this review, we summarized the assembly strategies for the preparation of DNA hydrogels on the basis of branched DNA modules, hybrid chain reaction (HCR)-synthesized DNA networks and rolling circle amplification (RCA)-produced DNA chains, respectively. The application of DNA hydrogels as drug delivery carriers in cancer therapy has been discussed. Finally, the future development directions of DNA hydrogels in cancer therapy are prospected.

Automated summary

DNA hydrogels, composed of three-dimensional networks of DNA chains, have shown great potential for drug delivery in cancer therapy due to their biocompatibility and programmability. By assembling functional DNA modules, DNA hydrogels can efficiently load anti-cancer drugs and achieve targeted drug delivery and controlled release. This review summarizes the assembly strategies for DNA hydrogel preparation and discusses their application as drug delivery carriers in cancer therapy. Future development directions of DNA hydrogels in cancer therapy are also discussed.