Writing and erasing ceramides to alter liver disease

M(6)A RNA modifications mediate RNA processing and stability. Ceramides are lipid metabolites containing an amino acid-based backbone, which promote metabolic dysfunction. Wang et al. describe a novel m(6)A-dependent regulatory node that tunes ceramide-generating enzymes.

Automated summary

M(6)A RNA modifications regulate RNA processing and stability, while ceramides, lipid metabolites with an amino acid-based backbone, promote metabolic dysfunction. Wang et al. describe a novel m(6)A-dependent regulatory node that controls ceramide-generating enzymes.