Inflamed macrophages sans mitochondrial pyruvate carrier?

Glycolysis provides building blocks for the proinflammatory activation of macrophages and simultaneously generates pyruvate. In this issue of Nature Metabolism, Ran et al. provide evidence that the transport of pyruvate to fuel the Krebs cycle in the mitochondria is not required in the inflammatory response.

Automated summary

Glycolysis fuels inflammatory response in macrophages and produces pyruvate. However, a study in Nature Metabolism by Ran et al. shows that transporting pyruvate to the mitochondria for Krebs cycle is not necessary for inflammation.