Oxidase-like Nanozyme Activity of Manganese Metal-Organic Framework Nanosheets for Colorimetric and Fluorescence Sensing of L-Cysteine

The utilization of ultrathin Mn-metal-organic framework (Mn-UMOF) nanosheets for oxidase-like nanozyme activity has been demonstrated. The Mn-UMOF exhibited superior nanozyme activity to oxidize chromogenic TMB and ABTS than the bulk Mn-BMOF. Based on this fact, a platform for the colorimetric sensing of L-cysteine (L-cys) has been established over the detection of other amino acids and natural compounds such as urea and glucose. In addition, the Mn-UMOF has the capability of catalyzing the oxidation of amplex red to the fluorescent first oxidized product, which has been used to develop a fluorescence turn-off sensor for the selective sensing of L-cys.

Automated summary

The utilization of ultrathin Mn-metal-organic framework (Mn-UMOF) nanosheets as oxidase-like nanozymes has been demonstrated. Mn-UMOF exhibited superior nanozyme activity compared to bulk Mn-BMOF, showing enhanced oxidation of chromogenic TMB and ABTS. Based on this, a colorimetric sensing platform for L-cysteine detection has been established, allowing for the detection of other amino acids and natural compounds such as urea and glucose.