4.5 Review

Neurological Soft Signs in Schizophrenia, a Picture of the Knowledge in the Last Decade: A Scoping Review

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Psychiatry

Neurological soft signs and structural network changes: a longitudinal analysis in first-episode schizophrenia

Li Kong et al.

Summary: This study found that neurological soft signs (NSS) are associated with disrupted network connectivity in patients with first-episode schizophrenia, and these associations change over time during the course of the disorder.

BMC PSYCHIATRY (2023)

Article Psychiatry

Structural network alterations and their association with neurological soft signs in schizophrenia: Evidence from clinical patients and unaffected siblings

Li Kong et al.

Summary: This study explored the association between neurological soft signs (NSS) and structural brain network characteristics in schizophrenia patients and their unaffected siblings. The results revealed grey matter reductions in specific brain networks in schizophrenia patients compared to healthy controls and unaffected siblings. Further analysis showed NSS-related grey matter covarying patterns in different groups, suggesting that brain regions implicated in genetic liability to schizophrenia are partially separated from those implicated in neural abnormalities.

SCHIZOPHRENIA RESEARCH (2022)

Article Psychiatry

Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia

Petra Verena Viher et al.

Summary: Neurological soft signs (NSS) are associated with grey matter and functional brain abnormalities in schizophrenia. Studies suggest that NSS are also linked to white matter. This study investigated the relationship between NSS and white matter alterations in patients with schizophrenia, finding a positive association between NSS and various diffusion measures in important motor pathways.

SCHIZOPHRENIA BULLETIN (2022)

Review Psychiatry

The neural substrates of neurological soft signs in schizophrenia: a systematic review

Genelle D. Samson et al.

Summary: Neurological soft signs (NSS) are common in patients with schizophrenia, with the basal ganglia and cerebellum implicated as structural substrates. Somatomotor and somatosensory regions, as well as areas involved in visual processing and spatial orientation, are suggested to underlie NSS in psychosis spectrum disorders. Dysfunction of frontoparietal and cerebellar networks has also been implicated. However, it remains unclear if white matter integrity deficits or neurometabolic alterations contribute to NSS in schizophrenia. Knowledge about the temporal evolution of NSS and associated brain signatures is limited. Future studies addressing these gaps will be important.

SCHIZOPHRENIA (2022)

Article Biochemistry & Molecular Biology

The Impact of Antipsychotic Treatment on Neurological Soft Signs in Patients with Predominantly Negative Symptoms of Schizophrenia

Cristian Petrescu et al.

Summary: This study aims to compare the profile of neurological soft signs in patients with predominantly negative symptoms of schizophrenia with patients who do not present a predominance of negative symptoms, as well as to assess the impact of treatment on the neurological function of these patients.

BIOMEDICINES (2022)

Article Psychology, Clinical

Motor abnormalities and basal ganglia in first-episode psychosis (FEP)

Manuel J. Cuesta et al.

Summary: This study found that first-episode psychosis patients had local atrophic and hypertrophic changes in the basal ganglia, and iron load may be associated with symptoms such as extrapyramidal signs and neurological soft signs.

PSYCHOLOGICAL MEDICINE (2021)

Article Psychiatry

Neurological Soft Signs Predict Auditory Verbal Hallucinations in Patients With Schizophrenia

Robert C. Wolf et al.

Summary: The study found significant associations between neurological soft signs and auditory verbal hallucinations in schizophrenia patients, but not with delusions. The integration function of neurological soft signs was positively correlated with the severity of auditory verbal hallucinations. This suggests important interrelationships between sensorimotor integration abilities, brain structure and function, and auditory verbal hallucination symptom expression.

SCHIZOPHRENIA BULLETIN (2021)

Article Psychiatry

Neurological Soft Signs Are Associated With Altered Cerebellar-Cerebral Functional Connectivity in Schizophrenia

Xin-Lu Cai et al.

Summary: The study revealed correlations between neurological soft signs (NSS) and cerebellar-cerebral resting-state functional connectivity (rsFC) in schizophrenia patients, suggesting a link with negative symptoms. The uncoupling of rsFC between the cerebellum and prefrontal regions may underlie the expression of NSS and provide a potential neural pathway for alleviating negative symptoms.

SCHIZOPHRENIA BULLETIN (2021)

Article Psychiatry

How soft are neurological soft signs? Content overlap analysis of 71 symptoms among seven most commonly used neurological soft signs scales

Adrian Andrzej Chrobak et al.

Summary: The study revealed a low overlap between different assessment tools for neurological soft signs, which limits reproducibility and hinders the unification of knowledge from existing data. The diversity in NSS assessment tools suggests the need for further research on the non-localizable nature of NSS.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

Review Psychiatry

Psychosocial and psychological interventions for relapse prevention in schizophrenia: a systematic review and network meta

Irene Bighelli et al.

Summary: This study evaluated the efficacy of psychosocial and psychological interventions in preventing relapse in patients with schizophrenia. The findings suggest that family interventions, family psychoeducation, and cognitive behavioral therapy can reduce the risk of relapse and should be considered as preferred interventions for long-term treatment.

LANCET PSYCHIATRY (2021)

Article Clinical Neurology

Neurological soft signs in schizophrenia spectrum disorders are not confounded by current antipsychotic dosage

Stefan Fritze et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2020)

Article Clinical Neurology

Neurological soft signs (NSS) and gray matter volume (GMV) in first-episode psychosis: An analysis of NSS motor subscores

David Quispe Escudero et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2020)

Editorial Material Clinical Neurology

Neurological soft signs predict outcomes in schizophrenia

Johannes Schroeder et al.

NATURE REVIEWS NEUROLOGY (2020)

Article Psychiatry

Neurological soft signs in familial and sporadic schizophrenia

Konstantinos N. Fountoulakis et al.

PSYCHIATRY RESEARCH (2019)

Article Psychiatry

12-Month stability of neurological soft signs in stabilized patients with schizophrenia

Konstantinos N. Fountoulakis et al.

NORDIC JOURNAL OF PSYCHIATRY (2019)

Article Medicine, General & Internal

Risk Model Assessment in Early-Onset and Adult-Onset Schizophrenia Using Neurological Soft Signs

Bao-Yu Chen et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Psychiatry

Neurological soft signs (NSS) and cognitive impairment in chronic schizophrenia

Christina J. Herold et al.

SCHIZOPHRENIA RESEARCH-COGNITION (2019)

Article Clinical Neurology

Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia

Raymond C. K. Chan et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2018)

Article Medicine, General & Internal

PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation

Andrea C. Tricco et al.

ANNALS OF INTERNAL MEDICINE (2018)

Article Behavioral Sciences

Local brain gyrification as a marker of neurological soft signs in schizophrenia

Dusan Hirjak et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

Article Neurosciences

Aberrant cerebellar connectivity in motor and association networks in schizophrenia

Ann K. Shinn et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2015)

Review Pharmacology & Pharmacy

Clinical management of negative symptoms of schizophrenia: An update

Evangelia M. Tsapakis et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Neurosciences

Heritability of Structural Brain Network Topology: A DTI Study of 156 Twins

Marc M. Bohlken et al.

HUMAN BRAIN MAPPING (2014)

Editorial Material Pharmacology & Pharmacy

Clinical Practice to Change With Divorce of Catatonia and Schizophrenia

Max Fink

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2013)

Article Neurosciences

Neurological Soft Signs and Brainstem Morphology in First-Episode Schizophrenia

Dusan Hirjak et al.

NEUROPSYCHOBIOLOGY (2013)

Article Clinical Neurology

Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder

Qing Zhao et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

Article Psychology, Developmental

Longitudinal study of neurological soft signs in first-episode early-onset psychosis

M. Mayoral et al.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2012)

Review Neurosciences

Motor Symptoms and Schizophrenia

Sebastian Walther et al.

NEUROPSYCHOBIOLOGY (2012)

Article Psychiatry

Neurological soft signs in schizophrenia - The past, the present and the future

Shivarama Varambally et al.

Indian Journal of Psychiatry (2012)

Review Clinical Neurology

Measuring catatonia: A systematic review of rating scales

Pascal Sienaert et al.

JOURNAL OF AFFECTIVE DISORDERS (2011)

Article Clinical Neurology

Motor Behavior Abnormalities in Drug-Naive Patients with Schizophrenia Spectrum Disorders

Victor Peralta et al.

MOVEMENT DISORDERS (2010)

Article Psychiatry

Neurological Soft Signs in Schizophrenia: A Meta-analysis

Raymond C. K. Chan et al.

SCHIZOPHRENIA BULLETIN (2010)

Article Psychiatry

Neurological abnormalities and cognitive ability in first-episode psychosis

Paola Dazzan et al.

BRITISH JOURNAL OF PSYCHIATRY (2008)

Article Psychology, Clinical

Movement abnormalities predict conversion to axis I psychosis among prodromal adolescents

Vijay A. Mittal et al.

JOURNAL OF ABNORMAL PSYCHOLOGY (2007)

Article Neurosciences

Neurological abnormalities in schizophrenic twins

MM Picchioni et al.

BIOLOGICAL PSYCHIATRY (2006)

Article Psychiatry

Neurological soft signs in first-episode schizophrenia:: A follow-up study

S Bachmann et al.

AMERICAN JOURNAL OF PSYCHIATRY (2005)

Article Psychiatry

Assessment tools for soft signs

I Bombin et al.

PSYCHIATRIC ANNALS (2003)

Article Psychiatry

Neurological soft signs in first-episode psychosis: a systematic review

P Dazzan et al.

BRITISH JOURNAL OF PSYCHIATRY (2002)

Article Psychiatry

Volumes of brain structures in twins discordant for schizophrenia

WFC Baare et al.

ARCHIVES OF GENERAL PSYCHIATRY (2001)

Review Psychiatry

The specificity of neurological signs in schizophrenia: a review

MPM Boks et al.

SCHIZOPHRENIA RESEARCH (2000)

Article Psychiatry

Genetic influence on laterality in schizophrenia?: A twin study of neurological soft signs

R Niethammer et al.

AMERICAN JOURNAL OF PSYCHIATRY (2000)