Diagnosis and Management of a Triple Infection with Leptospira spp., Hepatitis A Virus, and Epstein-Barr Virus: A Rare Occurrence with High Hepatotoxic Effect

Article Medicine, General & Internal

Leptospirosis: clinical aspects

Senaka Rajapakse

Summary: This article provides an overview of the epidemiology, clinical manifestations, diagnosis and treatment of human leptospirosis.

CLINICAL MEDICINE (2022)

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Article Infectious Diseases

Rainfall and other meteorological factors as drivers of urban transmission of leptospirosis

Marcelo Cunha et al.

Summary: This study investigated the association between leptospirosis incidence and meteorological factors in Salvador, Brazil. The findings suggest that higher than expected rainfall, lower than expected temperature, and higher than expected humidity are associated with an increase in leptospirosis cases. Additionally, a cumulative rainfall anomaly of 20 mm per week increased the risk of leptospirosis by 12%.

PLOS NEGLECTED TROPICAL DISEASES (2022)

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Review Agriculture, Dairy & Animal Science

Insight into the Epidemiology of Leptospirosis: A Review of Leptospira Isolations from Unconventional Hosts

Giovanni Cilia et al.

Summary: Isolation of Leptospira is crucial for assessing infection in various animal species. The increase in leptospirosis cases in the past 30 years may be attributed to problematic sampling methods, newly identified strains, underestimated cases, and climate change. Unconventional hosts play an important role in the epidemiology of Leptospira infection.

ANIMALS (2021)

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Review Virology

Mechanisms of Hepatocellular Injury in Hepatitis A

Minghang Wang et al.

Summary: Hepatitis A virus (HAV) infection is a common cause of acute viral hepatitis, and while virus-specific cytotoxic T cells were previously believed to be responsible for liver injury, recent evidence suggests that natural killer (NK) cells, NKT cells, and even non-HAV-specific CD8(+) T cells may also contribute to liver damage. Intrinsic death of virus-infected hepatocytes and genetic variations in host factors have also been linked to hepatitis A severity. Understanding these mechanisms could improve diagnosis and treatment of diseases associated with HAV infection.

VIRUSES-BASEL (2021)

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Article Immunology