期刊
LUPUS
卷 26, 期 2, 页码 139-149出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203316655208
关键词
Anti-dsDNA antibodies; S100A12; S100A8; A9; SLE glomerulonephritis; systemic lupus erythematosus
类别
资金
- Medical Faculty at Lund University
- Greta and Johan Kock's Foundation
- King Gustaf V's 80th Birthday Foundation
- Lund University Hospital
- Swedish Rheumatism Association
- Osterlund's Foundation
Objectives Systemic lupus erythematosus (SLE) is associated with elevated levels of S100A8/A9, pro-inflammatory proteins mainly secreted by activated polymorphonuclear neutrophils (PMNs). The underlying mechanisms for increased S100A8/A9 levels and their relation to the clinical phenotype have not been carefully investigated. We assessed S100A8/A9 and S100A12 levels in SLE patient sera in relation to disease activity, clinical phenotype, presence of anti-dsDNA antibodies and ability to promote phagocytosis of necrotic cells (NCs) by PMNs. Methods Serum levels of S100A8/A9 and S100A12 were measured by ELISA in paired samples of 100 SLE patients at time points of higher and lower disease activity. Serum-mediated phagocytosis of NCs by PMNs was analysed by flow cytometry. Clinical data were recorded at time points of blood sampling. Results Serum levels of S100A8/A9 and S100A12 were increased in SLE patients with high disease activity compared to paired samples at low disease activity (p=0.01 and p=0.008, respectively). Elevated levels of S100A8/A9 were particularly seen in patients with anti-dsDNA antibodies (p=0.01) and glomerulonephritis before treatment (p=0.02). Immunosuppressive therapy was associated with a reduction of S100A8/A9 serum levels (p=0.002). The ability of serum to support phagocytosis of NCs by PMNs was related to increased S100A8/A9 levels (p=0.01). Conclusions Elevated serum levels of S100A8/A9 may be used to monitor disease activity and response to treatment in SLE patients, especially in patients with glomerulonephritis. S100A12 may be a marker of disease activity in SLE. Increased S100A8/A9 levels may reflect immune-pathological processes involving phagocytosis of immune complexes by PMNs.
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