期刊
LUPUS
卷 25, 期 9, 页码 997-1003出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203316629556
关键词
Central neuropsychiatric lupus erythematosus; cerebrospinal fluid; IL-6; IL-8; IP-10; MCP-1; G-CSF; antiribosomal P protein antibodies
类别
资金
- Ministry of Education, Culture, Science and Sports of Japan [15591063]
- Grants-in-Aid for Scientific Research [15591063, 15K09556] Funding Source: KAKEN
Objective To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum concentrations in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain whether the increased production of cytokines/chemokines intrathecally relative to serum levels is associated with the presence of central NPSLE. Methods 52 SLE patients (30 with central NPSLE and 22 with non-NPSLE), for whom the CSF and serum samples were obtained at the same time, were enrolled. 27 kinds of cytokine/chemokine concentrations other than IFN- in the cerebrospinal fluid (CSF) and serum samples were measured by Bio-Plex Pro Assays. IFN- concentration and anti-ribosomal P protein antibody (anti-P) titres in CSF and serum samples were measured by ELISA. Results The mean concentrations of IL-6, IL-8, IP-10, MCP-1, G-CSF and GM-CSF were higher in the CSF than in the sera, respectively, while the mean concentrations of other 22 cytokines/chemokines, including RANTES and IFN-, in the CSF were much lower than those in the sera, respectively. Furthermore, the concentrations of IL-6, IL-8, IP-10, MCP-1 and G-CSF in the CSF of the 30 patients with NPSLE were significantly higher than in the 22 patients with non-NPSLE (p=6.82x10(-5), p=0.00037, p=0.0028, p=0.00065, and p=0.0001, respectively), while the concentration of GM-CSF in the CSF of the 30 patients with NPSLE was not significantly higher than in the 22 patients with non-NPSLE. Most importantly, the largest difference occurred in CSF IL-6 concentrations. A significant positive correlation between CSF anti-P titres and serum anti-P titres in 52 patients with SLE (r=0.6316, p=6.44x10(-6)) was found, while no significant positive correlation was observed between CSF levels and serum levels of each cytokine/chemokine in the 52 SLE patients. Conclusion In central NPSLE the production of IL-6, IL-8, IP-10, MCP-1 and G-CSF might take place in the central nervous system (CNS). These increased CSF cytokines/chemokines along with anti-P might have a prerequisite role in the pathogenesis of central NPSLE.
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