Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: A review

Editorial Material Immunology

The polio vaccination story of Pakistan

Shabina Rahim et al.

Summary: This article chronicles Pakistan's decades-long battle against poliovirus and evaluates the various factors influencing it. Pakistan faces numerous challenges in eradicating polio and urgent action is needed.

VACCINE (2022)

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Article Infectious Diseases

Willingness to accept malaria vaccine among caregivers of under-5 children in Southwest Ethiopia: a community based cross-sectional study

Getachew Asmare

Summary: The willingness to accept a malaria vaccine for children among caregivers of children under the age of five was low in the study area. Marital status, knowledge, and previous experience with childhood vaccination were found to be significantly associated with willingness to accept a malaria vaccine for their children.

MALARIA JOURNAL (2022)

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Article Infectious Diseases

Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and study set-up

Nicolas Praet et al.

Summary: GSK has developed a post-approval plan consisting of four complementary Phase IV studies to evaluate the safety, effectiveness, and impact of the RTS,S/AS01(E) vaccine. These studies aim to address important knowledge gaps and inform decision-making for the potential wider implementation of the vaccine across sub-Saharan Africa.

MALARIA JOURNAL (2022)

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Review Multidisciplinary Sciences

Determinants of COVID-19 vaccine acceptance in Ethiopia: A systematic review and meta-analysis

Ayenew Mose et al.

Summary: This study conducted a systematic review and meta-analysis on the prevalence of COVID-19 vaccine acceptance and its determinants in Ethiopia. The results showed a low acceptance rate, with being male, having secondary and above educational status, good knowledge, and positive attitude being key determinants.

PLOS ONE (2022)

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Article Pharmacology & Pharmacy

RTS,S/AS01 malaria vaccine (Mosquirix(R)): a profile of its use

Yahiya Y. Syed

Summary: RTS,S/AS01 vaccine demonstrates efficacy against malaria caused by Plasmodium falciparum. It is safe, well-tolerated, and has shown positive results in pilot implementation in Africa, leading to its recommendation by WHO for malaria prevention in children. It improves access to prevention, is cost-effective, and reduces the burden of severe malaria.

DRUGS & THERAPY PERSPECTIVES (2022)

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Review Health Care Sciences & Services

Towards Eradication of Malaria: Is the WHO's RTS,S/AS01 Vaccination Effective Enough?

Navneet Arora et al.

Summary: The RTS,S/AS01 vaccine is safe and immunogenic in children, but has modest efficacy against clinical malaria and requires a booster dose for improved protection. Its cost-effectiveness and potential public health impact are being assessed for wider deployment.

RISK MANAGEMENT AND HEALTHCARE POLICY (2021)

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Article Infectious Diseases

Are malaria transmission-blocking vaccines acceptable to high burden communities? Results from a mixed methods study in Bo, Sierra Leone

Kaci D. McCoy et al.

Summary: The study found that most adults in Bo, Sierra Leone are willing to accept a TBV vaccine as part of an integrated anti-malarial strategy. Perceived barriers to TBV acceptance were focused on community-level distribution, personal fears of vaccination, and potential costs. Parents and health workers provided insight on successfully rolling out a future TBV vaccination program.

MALARIA JOURNAL (2021)

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Article Infectious Diseases

Factors associated with malaria vaccine uptake in Sunyani Municipality, Ghana

Dennis Tabiri et al.

Summary: The study found that the coverage of RTS,S 1 and RTS,S 2 vaccination in Sunyani Municipality of Ghana meets the target set by WHO, but the uptake of RTS,S 3 falls short. Additionally, there is a growing perception among parents/caregivers that there are too many vaccines for children, which negatively impacts vaccination rates.

MALARIA JOURNAL (2021)

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Article Immunology

Assessing the Level and Determinants of COVID-19 Vaccine Confidence in Kenya

Stacey Orangi et al.

Summary: Kenya has a high rate of COVID-19 vaccine hesitancy at 36.5%, with factors such as rural regions, perceived difficulty in adhering to government regulations, no perceived infection risk, concerns about vaccine safety and effectiveness, and religious/cultural reasons being associated with hesitancy. Interventions to address vaccine hesitancy and improve vaccine confidence should prioritize holistic messaging targeting specific groups to communicate the risks and benefits of vaccines.

VACCINES (2021)

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Article Infectious Diseases

COVID-19 vaccine hesitancy among staff and students in a Nigerian tertiary educational institution

Ikemefuna Chijioke Uzochukwu et al.

Summary: Only about 34.70% of the Nnamdi Azikiwe University community are willing to receive the COVID-19 vaccine, with a high hesitancy rate of 65.04%. Marital status, age, and christian denominational affiliation significantly influence respondents' perception of COVID-19 vaccination, while factors such as gender, occupation, previous vaccination experience, awareness of COVID-19, and previous symptoms of COVID-19 do not significantly affect respondents' willingness to be vaccinated.

THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE (2021)

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Review Biotechnology & Applied Microbiology