4.6 Review

Deciphering Lung Adenocarcinoma Heterogeneity: An Overview of Pathological and Clinical Features of Rare Subtypes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

European cancer mortality predictions for the year 2023 with focus on lung cancer

M. Malvezzi et al.

Summary: This study predicts cancer mortality figures for 2023 in the European Union, its five most populous countries, and the UK, with a focus on lung cancer. The results show that the decline in lung cancer mortality reflects advancements in tobacco control, and further efforts are needed to control overweight and obesity, alcohol consumption, infection, and related neoplasms, as well as improve screening, early diagnosis, and treatments. These efforts may achieve a 35% reduction in cancer mortality in the EU by 2035.

ANNALS OF ONCOLOGY (2023)

Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

Article Pathology

Genetic mutation profiles and immune microenvironment analysis of pulmonary enteric adenocarcinoma

Min Xie et al.

Summary: This study provides insights into the molecular and immune characteristics of pulmonary enteric adenocarcinoma (PEAC), including low-frequency RTK gene mutation, high KRAS mutation, low PD-L1 expression, low TMB, and low CD8+ T cell infiltration.

DIAGNOSTIC PATHOLOGY (2022)

Article Oncology

Hyperprogressive Disease After Immunotherapy: A Case Report of Pulmonary Enteric Adenocarcinoma

Chun-Hong Hu et al.

Summary: Primary pulmonary enteric adenocarcinoma (PEAC) is a rare invasive adenocarcinoma similar to metastatic colorectal adenocarcinoma (MCRC). This report presents a case of a 61-year-old male patient with PEAC showing unresponsiveness to a combination chemotherapy regimen and immunotherapy.

FRONTIERS IN ONCOLOGY (2022)

Article Pathology

Clinicopathological and genetic analyses of pulmonary enteric adenocarcinoma

Fumi Okada et al.

Summary: This study conducted clinicopathological, immunohistochemical, and molecular analyses on pulmonary enteric adenocarcinoma (PEAC) and compared the results with invasive mucinous adenocarcinoma (IMA). The findings indicate significant differences in clinical and molecular characteristics between PEAC and IMA.

JOURNAL OF CLINICAL PATHOLOGY (2022)

Article Medicine, General & Internal

Genomic and epigenomic profiles distinguish pulmonary enteric adenocarcinoma from lung metastatic colorectal cancer

Ying Zuo et al.

Summary: This study investigates the molecular characteristics of pulmonary enteric adenocarcinoma (PEAC) and lung metastatic colorectal cancer (lmCRC). The results reveal that EGFR is the key driver mutation in PEAC, while KRAS and ERBB2 are more frequently observed. In lmCRC, KRAS and APC mutations are significantly enriched. Copy number variations in certain chromosome arms were also observed between PEAC and lmCRC. Additionally, a DNA methylation-based classifier consisting of eight differentially methylated regions (DMRs) was established, providing a reliable auxiliary diagnosis for PEAC and lmCRC.

EBIOMEDICINE (2022)

Article Oncology

Long-Term Overall Survival From KEYNOTE-021 Cohort G: Pemetrexed and Carboplatin With or Without Pembrolizumab as First-Line Therapy for Advanced Nonsquamous NSCLC

Mark M. Awad et al.

Summary: First-line pembrolizumab plus pemetrexed-carboplatin showed continued improved response and survival compared to chemotherapy alone in advanced nonsquamous NSCLC, with durable clinical benefit in patients who completed 2 years of therapy. No new safety signals were observed with longer follow-up.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Oncology

Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes

Jason C. Chang et al.

Summary: The study conducted comprehensive analysis of invasive mucinous adenocarcinoma (IMA) using broad DNA- and RNA-sequencing methods, revealing multiple driver mutations including targetable gene fusions in 51% of KRAS wild-type IMAs. NRG1-rearranged tumors exhibited more aggressive characteristics than KRAS-mutant IMAs.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Pulmonary enteric adenocarcinoma

Jiali Gong et al.

Summary: PEAC is an exceptionally rare subtype of lung cancer with features similar to colorectal adenocarcinoma. It has unique mutation expression and immune characteristics, with potential for targeted therapy in the future.

TRANSLATIONAL ONCOLOGY (2021)

Review Oncology

Sex-specificity in lung cancer risk

Claudia Stapelfeld et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Review Respiratory System

Pulmonary enteric adenocarcinoma: a literature review

Haiyan Li et al.

JOURNAL OF THORACIC DISEASE (2020)

Review Biochemistry & Molecular Biology

Pulmonary enteric adenocarcinoma: an overview

Raffaele Palmirotta et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2020)

Article Respiratory System

Risk factors for lung cancer worldwide

Jyoti Malhotra et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

Article Oncology

Epidemiology of Lung Cancer

Yousheng Mao et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2016)

Article Medical Laboratory Technology

Colloid carcinoma of the lung: Current views

Neda Kalhor

SEMINARS IN DIAGNOSTIC PATHOLOGY (2014)

Article Pathology

HNF4α as a Marker for Invasive Mucinous Adenocarcinoma of the Lung

Masato Sugano et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2013)

Article Pathology

Aspiration Cytomorphology of Fetal Adenocarcinoma of the Lung

Kim R. Geisinger et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2010)

Review Oncology

Lung cancer in never smokers - a different disease

Sophie Sun et al.

NATURE REVIEWS CANCER (2007)

Article Pathology

Cytology of pulmonary adenocarcinomas showing enteric differentiation

Yukitoshi Satoh et al.

ACTA CYTOLOGICA (2006)