The rs2682826 Polymorphism of the NOS1 Gene Is Associated with the Degree of Disability of Erectile Dysfunction

Article Andrology

Expression and Distribution of Free Zinc in Penile Erectile Tissue

Beom Seok Kang et al.

Summary: This study evaluated the expression and distribution of free zinc in penile tissue and suggested its potential role in penile erection.

WORLD JOURNAL OF MENS HEALTH (2023)

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Review Biochemistry & Molecular Biology

Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts

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Summary: This article discusses the role of phosphodiesterases (PDEs) in regulating cardiac contractility and their changes in heart failure.

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Review Cardiac & Cardiovascular Systems

Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs

Dimitrios Terentes-Printzios et al.

Summary: The translation discusses the importance of sexual health in overall health and well-being, focusing on the prevalence of sexual dysfunction, particularly erectile dysfunction (ED), in cardiovascular disease (CVD) patients. Shared risk factors and pathophysiological links between CVD and ED highlight the need for screening and diagnosing ED for preventive measures. This Review emphasizes the incorporation of sexual function into the patient history by physicians treating CVD patients to improve quality of life and cardiovascular outcomes.

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Review Peripheral Vascular Disease

Hypertension and Erectile Dysfunction: Breaking Down the Challenges

Amanda Almeida de Oliveira et al.

Summary: The link between hypertension and erectile dysfunction is primarily through mechanisms such as endothelial dysfunction, procontractile factors, and increased generation of reactive oxygen species. The innate immune system has also been found to play a significant role in the pathophysiology of hypertension and ED.

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Article Urology & Nephrology

Erectile Dysfunction in a Sample of Sexually Active Young Adult Men from a US Cohort: Demographic, Metabolic and Mental Health Correlates

Jerel P. Calzo et al.

Summary: The study found a high prevalence of erectile dysfunction among sexually active young adult men aged 18 to 31 in the United States, which was associated with relationship status and mental health.

JOURNAL OF UROLOGY (2021)

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Review Chemistry, Multidisciplinary

The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

Nicolai Lehnert et al.

Summary: Nitric oxide (NO) is a crucial signaling molecule in biology, with metal coordination chemistry playing a key role in its biological transformations. Various proteins and small molecules are involved in the biosynthesis, sensing, and transport of NO, which leads to a wide range of biological activities through its rich reaction chemistry.

CHEMICAL REVIEWS (2021)

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Review Medicine, Research & Experimental

Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors

Wesam S. Ahmed et al.

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Article Urology & Nephrology

Physiology of Erection and Pathophysiology of Erectile Dysfunction

Susan M. MacDonald et al.

UROLOGIC CLINICS OF NORTH AMERICA (2021)

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Review Urology & Nephrology

European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction

Andrea Salonia et al.

Summary: This study presents a summary of the European Association of Urology (EAU) guidelines on male sexual and reproductive health published in 2021. It covers topics such as late-onset hypogonadism, erectile dysfunction, premature ejaculation, and haemospermia, providing recommendations for diagnosis and treatment of these common conditions in men.

EUROPEAN UROLOGY (2021)

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Article Biochemistry & Molecular Biology

The synthetic peptide PnPP-19 potentiates erectile function via nNOS and iNOS

Carolina Nunes da Silva et al.

Summary: PnPP-19 peptide potentiates erectile function through nitric oxide activation, with a key role of endothelial nitric oxide synthase, and inducible nitric oxide synthase enhancing its effect on erectile function.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Regulation of NOS expression in vascular diseases

Andrea Pautz et al.

Summary: Nitric oxide synthases (NOS) are major sources of nitric oxide (NO) in the vasculature and play a crucial role in regulating vascular tone and blood pressure. While NOS3 is the most important for maintaining vascular tone, evidence suggests that NOS1 and NOS2 also contribute to vascular function. Regulation of NOS expression in the vasculature involves various mechanisms including transcriptional, post-transcriptional, and post-translational processes, particularly in the context of inflammation and innate immune pathways.

FRONTIERS IN BIOSCIENCE-LANDMARK (2021)

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Article Biochemistry & Molecular Biology

Nitric oxide in cellular adaptation and disease

Benjamin N. Gantner et al.

REDOX BIOLOGY (2020)

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Article Psychiatry

Association Analysis of Neuronal Nitric Oxide Synthase 1 Gene Polymorphism With Psychopathological Symptoms in Chronic Ketamine Users

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FRONTIERS IN PSYCHIATRY (2020)

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Review Endocrinology & Metabolism

Association between polymorphisms of NOS1, NOS2 and NOS3 genes and suicide behavior: a systematic review and meta-analysis

Thelma Beatriz Gonzalez-Castro et al.

METABOLIC BRAIN DISEASE (2019)

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Article Biochemistry & Molecular Biology

Influence of two functional polymorphisms in NOS1 on baseline cortisol and working memory in healthy subjects

N. J. Roth et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls

Guilhermo Brites-Anselmi et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

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Article Urology & Nephrology

Erectile Dysfunction: AUA Guideline

Arthur L. Burnett et al.

JOURNAL OF UROLOGY (2018)

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Article Biochemistry & Molecular Biology

Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease

Bruno Lopes Santos-Lobato et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Genetic alterations in the NO-cGMP pathway and cardiovascular risk

Jana Wobst et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans

Rastislav Rovny et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

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Article Pharmacology & Pharmacy

Gene-Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril

Gustavo H. Oliveira-Paula et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2017)

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Article Genetics & Heredity

Nitric oxide pathway genes (NOS1AP and NOS1) are involved in PTSD severity, depression, anxiety, stress and resilience

Dagmar Bruenig et al.

GENE (2017)

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Article Neurosciences

Association Between NOS1 Gene Polymorphisms and Schizophrenia in Asian and Caucasian Populations: A Meta-Analysis

Shiek S. S. J. Ahmed et al.

NEUROMOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy

Ana Maria Milanez Azevedo et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2017)

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Review Urology & Nephrology

Erectile Dysfunction in Young Men-A Review of the Prevalence and Risk Factors

Hoang Minh Tue Nguyen et al.

SEXUAL MEDICINE REVIEWS (2017)

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Article Urology & Nephrology

PDE5A Polymorphisms Influence on Sildenafil Treatment Success

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JOURNAL OF SEXUAL MEDICINE (2016)

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Article Rehabilitation

Polymorphism of Nitric Oxide Synthase 1 Affects the Clinical Phenotypes of Ischemic Stroke in Korean Population

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ANNALS OF REHABILITATION MEDICINE-ARM (2016)

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Review Biotechnology & Applied Microbiology

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Michael Black et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2015)

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Article Gastroenterology & Hepatology

Achalasia Is Associated With eNOS4a4a, iNOS22GA, and nNOS29TT Genotypes: A Case-control Study

Rajan Singh et al.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2015)

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Review Biochemistry & Molecular Biology

Alternative polyadenylation in the nervous system: To what lengths will 3′ UTR extensions take us?

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BIOESSAYS (2014)

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Article Veterinary Sciences

Identification of PDE5A:E90K: A Polymorphism in the Canine Phosphodiesterase 5A Gene Affecting Basal cGMP Concentrations of Healthy Dogs

J. A. Stern et al.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2014)

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Article Pharmacology & Pharmacy

nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction

Riccardo Lacchini et al.

PHARMACOGENOMICS (2014)

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Review Pharmacology & Pharmacy

Pharmacogenetics of erectile dysfunction: navigating into uncharted waters

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PHARMACOGENOMICS (2014)

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Article Pharmacology & Pharmacy

eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril

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EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity

Milena A. Gebska et al.

CARDIOVASCULAR RESEARCH (2011)

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Article Clinical Neurology

A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia

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Article Medical Laboratory Technology

Interethnic differences in ADMA concentrations and negative association with nitric oxide formation in preeclampsia

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Article Biochemistry & Molecular Biology

A Gradient of NOS1 Overproduction Alleles in European and Mediterranean Populations

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Article Urology & Nephrology

Nebivolol Dilates Human Penile Arteries and Reverses Erectile Dysfunction in Diabetic Rats through Enhancement of Nitric Oxide Signaling

Javier Angulo et al.

JOURNAL OF SEXUAL MEDICINE (2010)

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Article Urology & Nephrology

Recovery of Erectile Function After Nerve Sparing Radical Prostatectomy and Penile Rehabilitation With Nightly Intraurethral Alprostadil Versus Sildenafil Citrate

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Article Pediatrics

Phosphodiesterase-5 gene (PDE5A) polymorphisms are associated with progression of childhood IgA nephropathy

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PEDIATRIC NEPHROLOGY (2010)

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Article Psychiatry

A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain

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SCHIZOPHRENIA RESEARCH (2010)

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Review Urology & Nephrology

Type 2 Diabetes Mellitus and Erectile Dysfunction

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JOURNAL OF SEXUAL MEDICINE (2009)

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Article Medicine, General & Internal

A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

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PGA: power calculator for case-control genetic association analyses

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Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease

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Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

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Article Biochemistry & Molecular Biology

A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function

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MOLECULAR PSYCHIATRY (2006)

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Article Urology & Nephrology

Evaluation of a progressive treatment program for erectile dysfunction in patients with diabetes mellitus

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INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2005)

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Article Urology & Nephrology

Intima-media thickening of common carotid arteries is a risk factor for severe erectile dysfunction in men with vascular risk factors but no clinical evidence of atherosclerosis

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JOURNAL OF UROLOGY (2005)

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Article Multidisciplinary Sciences

Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis

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Article Andrology

Cavernosal tissue nitrite, nitrate, malondialdehyde and glutathione levels in diabetic and non-diabetic erectile dysfunction

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INTERNATIONAL JOURNAL OF ANDROLOGY (2003)

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The rs2682826 Polymorphism of the NOS1 Gene Is Associated with the Degree of Disability of Erectile Dysfunction

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