☆ 4.6 Review

Critical Assessment of the Anti-Inflammatory Potential of Usnic Acid and Its Derivatives-A Review

LIFE-BASEL (2023)

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Review Immunology

Mitochondrial control of inflammation

Saverio Marchi et al.

Summary: This article discusses the molecular mechanisms by which mitochondrial dysfunction leads to inflammatory reactions, the cellular pathways that regulate them, and the pathological consequences of dysregulated inflammatory responses elicited by mitochondrial damage-associated molecular patterns (DAMPs).

NATURE REVIEWS IMMUNOLOGY (2023)

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Review Biochemistry & Molecular Biology

Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo

Hanxue Wang et al.

Summary: This paper provides a summary of the bioactivity, toxicity, metabolism, and pharmacokinetics of usnic acid, and offers reference for future research on this compound.

MOLECULES (2022)

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Review Toxicology

Toxicity of Usnic Acid: A Narrative Review

Nicoletta Croce et al.

Summary: Usnic acid is a naturally occurring compound found in lichens, with various biological activities. It has been used as a traditional medicine and a weight loss product, but was withdrawn from the market due to severe hepatotoxicity. Studies on the toxicology, genotoxicity, mutagenesis, and teratogenicity of usnic acid have been reviewed, as well as research on its topical use and efforts to enhance its pharmacological activity and reduce toxicity.

JOURNAL OF TOXICOLOGY (2022)

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Article Chemistry, Medicinal

A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers-A Comprehensive In Vitro Approach

Agnieszka Galanty et al.

Summary: Usnic acid, a chiral lichen metabolite, shows inhibitory effects on melanoma cells and may have synergistic effects with chemotherapeutic drugs. The effects of both UA enantiomers vary in different cell lines, but overall, they have promising anti-melanoma potential.

PHARMACEUTICALS (2021)

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Article Behavioral Sciences

Usnic acid enantiomers restore cognitive deficits and neurochemical alterations induced by Aβ1-42 in mice

Camila Andre Cazarin et al.

Summary: This study investigated the effects of UA enantiomers on cognitive deficits and neuroinflammation in mice with AD. The results showed that UA improved learning and memory, reduced oxidative stress markers, decreased neuroinflammation, and restored cognitive deficits induced by A beta 1-42 administration in mice.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Chemistry, Medicinal

Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties

Elzbieta Studzinska-Sroka et al.

Summary: Compounds derived from lichens have significant anti-tumor and anti-inflammatory properties, primarily exerting cytotoxicity against glioblastoma cells and able to cross the blood-brain barrier, making them suitable for CNS treatment.

PHARMACEUTICALS (2021)

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Article Neurosciences

Anti-inflammatory effects of usnic acid in an MPTP-induced mouse model of Parkinson's disease

Seulah Lee et al.

BRAIN RESEARCH (2020)

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Article Chemistry, Medicinal

Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors

Cun-Jian Shi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Plants as Sources of Anti-Inflammatory Agents

Clara dos Reis Nunes et al.

MOLECULES (2020)

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Review Plant Sciences

Enantioselective activity of usnic acid: a comprehensive review and future perspectives

Agnieszka Galanty et al.

PHYTOCHEMISTRY REVIEWS (2019)

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Article Medicine, Research & Experimental

The effects of sodium usnic acid by topical application on skin wound healing in rats

Zhiheng Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biochemistry & Molecular Biology

Synthesis and anti-inflammatory activity of novel triazole hybrids of (+)-usnic acid, the major dibenzofuran metabolite of the lichen Usnea longissima

Nagi Reddy Vanga et al.

MOLECULAR DIVERSITY (2017)

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Article Pharmacology & Pharmacy

Gelatin-based membrane containing usnic acid-loaded liposome improves dermal burn healing in a porcine model

Paula Santos Nunes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Article Immunology

Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress

Zu-Qing Su et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

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Article

Anti-inflammatory effects and mechanisms of usnic acid, a compound firstly isolated from lichen Parmelia saxatilis

Huang Zhijun et al.

Journal of Medicinal Plants Research (2014)

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Review Biochemistry & Molecular Biology

A Review on Anti-Inflammatory Activity of Monoterpenes

Rita de Cassia da Silveira e Sa et al.

MOLECULES (2013)

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Editorial Material Medicine, General & Internal

Acute lung injury

Dhruv Parekh et al.

CLINICAL MEDICINE (2011)

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Article

Review of Usnic Acid andUsnea BarbataToxicity

LEI GUO et al.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2008)

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Article Chemistry, Medicinal

Down-regulatory Effect of Usnic Acid on Nuclear Factor-κB-dependent Tumor Necrosis Factor-α and Inducible Nitric Oxide Synthase Expression in Lipopolysaccharide-stimulated Macrophages RAW 264.7

Ju-qing An et al.

PHYTOTHERAPY RESEARCH (2008)

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Article Pharmacology & Pharmacy

Nanoencapsulation of usnic acid: An attempt to improve antitumour activity and reduce hepatotoxicity

Noemia Pereira da Silva Santos et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2006)

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Article Plant Sciences

Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets

F Bucar et al.

PHYTOMEDICINE (2004)

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