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Potential of Lipid-Based Nanocarriers against Two Major Barriers to Drug Delivery-Skin and Blood-Brain Barrier

MEMBRANES (2023)

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Summary: Black cohosh is a popular herb used to alleviate menopausal symptoms. This study aimed to develop an ethosomal gel containing a triterpene enriched fraction from black cohosh and evaluate its efficacy through transdermal application. By using a quality by design approach, the optimized ethosomal gel showed better performance compared to the conventional gel. Additional animal studies are needed to further validate these results.

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Summary: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with a very poor prognosis, is hindered by the blood-brain barrier (BBB), which restricts the access of drugs commonly used in ALS to the brain. In this study, riluzole-loaded nanostructured lipid carriers (NLC) functionalized with lactoferrin (Lf) were prepared to overcome this limitation and increase brain targeting. The results showed that Lf-functionalized NLC exhibited a promising ability to target riluzole to the brain without causing significant toxicity to cells.

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Summary: Nanotechnology has a significant impact on medicine and drug delivery, addressing the limitations of conventional pharmaceutical agents. Many nanotechnology applications have been developed and nanotechnology-based medicines are now on the market. Nanotechnology attracts increasing investment worldwide. Pharmaceutical nanomedicine products are projected to play a major role in the global pharmaceutical market and healthcare system.

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Summary: This study aimed to develop and evaluate naproxen transethosomal gel for sustained transdermal delivery for the management of musculoskeletal pain. The results showed that the formulated transethosomal gel possessed a smaller particle size, high entrapment efficiency, and higher skin deposition rate. The developed formulation could be regarded as an ideal substitute for the conventional gel for the management of musculoskeletal pain.

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Thymoquinone-Enriched Naringenin-Loaded Nanostructured Lipid Carrier for Brain Delivery via Nasal Route: In Vitro Prospect and In Vivo Therapeutic Efficacy for the Treatment of Depression

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Yi-Qun Yu et al.

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Development of Imatinib Mesylate-Loaded Liposomes for Nose to Brain Delivery: In Vitro and In Vivo Evaluation

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Review Pharmacology & Pharmacy

Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation

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JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2011)

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Review Chemistry, Medicinal

Penetration of Nanoplarticles and Nanomaterials in the Skin: Fiction or Reality?

Biancamaria Baroli

JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

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Article Biochemistry & Molecular Biology

Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery

Pinaki Desai et al.

MOLECULAR MEMBRANE BIOLOGY (2010)

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Review Pharmacology & Pharmacy

Therapeutic and cosmeceutical potential of ethosomes: An overview

Poonam Verma et al.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2010)

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Review Pharmacology & Pharmacy

Niosome: A future of targeted drug delivery systems

Kazi Masud Karim et al.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2010)

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Article Engineering, Biomedical

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

Weilun Ke et al.

BIOMATERIALS (2009)

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Review Pharmacology & Pharmacy

Nanoparticles for direct nose-to-brain delivery of drugs

Alpesh Mistry et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)

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Review Peripheral Vascular Disease

The pericyte: Cellular regulator of microvascular blood flow

Matthew E. Kutcher et al.

MICROVASCULAR RESEARCH (2009)

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Review Pharmacology & Pharmacy

From nose to brain: understanding transport capacity and transport rate of drugs

Hongbing Wu et al.

EXPERT OPINION ON DRUG DELIVERY (2008)

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Review Pharmacology & Pharmacy

Micro-scale devices for transdermal drug delivery

Anubhav Arora et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Article Pharmacology & Pharmacy

Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy

Yi-Ping Fang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Review Biotechnology & Applied Microbiology

Transdermal drug delivery

Mark R. Prausnitz et al.

NATURE BIOTECHNOLOGY (2008)

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Review Dermatology

Application of microemulsions in dermal and transdermal drug delivery

P. Santos et al.

SKIN PHARMACOLOGY AND PHYSIOLOGY (2008)

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Review Dermatology

Delivering drugs by the transdermal route: review and comment

T. Tanner et al.

SKIN RESEARCH AND TECHNOLOGY (2008)

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Review Pharmacology & Pharmacy

Vesicles as tools for the modulation of skin permeability

Vaibhav Dubey et al.

EXPERT OPINION ON DRUG DELIVERY (2007)

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Review Pharmacology & Pharmacy

Lipid nanoparticles for improved topical application of drugs for skin diseases

Monika Schaefer-Korting et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Review Pharmacology & Pharmacy

Lipid vesicles for skin delivery of drugs: Reviewing three decades of research

Mustafa M. A. Elsayed et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

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Review Chemistry, Physical

Microemulsions as transdermal drug delivery vehicles

Anna Kogan et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2006)

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Article Pharmacology & Pharmacy

Deformable liposomes and ethosomes: Mechanism of enhanced skin delivery

Mustafa M. A. Elsayed et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

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Review Neurosciences

Astrocyte-endothelial interactions at the blood-brain barrier

NJ Abbott et al.

NATURE REVIEWS NEUROSCIENCE (2006)

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Article Chemistry, Multidisciplinary

Paclitaxel nanoparticles for the potential treatment of brain tumors

JM Koziara et al.

JOURNAL OF CONTROLLED RELEASE (2004)

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Article Chemistry, Physical

Formation and stability of nano-emulsions

T Tadros et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2004)

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Article Pharmacology & Pharmacy

Enhanced delivery of octreotide to the brain via transnasal iontophoretic administration

EN Lerner et al.

JOURNAL OF DRUG TARGETING (2004)

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Article Dermatology

The organization of human epidermis: Functional epidermal units and phi proportionality

SB Hoath et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

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Article Pharmacology & Pharmacy

Particle size of liposomes influences dermal delivery of substances into skin

DD Verma et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2003)

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Article Pharmacology & Pharmacy

Cosmetic applications for solid lipid nanoparticles (SLN)

SA Wissing et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2003)

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Article Cell Biology

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis

M Hellström et al.

JOURNAL OF CELL BIOLOGY (2001)

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Review Pharmacology & Pharmacy

Nanoparticulate systems for brain delivery of drugs

J Kreuter

ADVANCED DRUG DELIVERY REVIEWS (2001)

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Article Pharmacology & Pharmacy

Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids

V Jenning et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2000)

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Article Chemistry, Multidisciplinary

Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties

E Touitou et al.

JOURNAL OF CONTROLLED RELEASE (2000)

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