☆ 4.5 Review

Recent Advances in Electrochemiluminescence-Based Single-Cell Analysis

CHEMOSENSORS (2023)

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Review Chemistry, Multidisciplinary

Recent Advances in Single Cell Analysis by Electrochemiluminescence

Hao Ding et al.

Summary: Understanding cellular mechanisms is a major goal in biology, and single cell measurements are more accurate than population-averaged assays for studying cellular systems. Electrochemiluminescence (ECL) is an emerging method for single cell analysis, which involves light emission triggered by electrochemical reactions. This review provides an overview of recent research progress on ECL principles and systems for analyzing single cells, including various analytes and their impact on cellular functions.

CHEMISTRYOPEN (2023)

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Article Chemistry, Multidisciplinary

Wireless Electrochemical Visualization of Intracellular Antigens in Single Cells

Yuling Wang et al.

Summary: This study demonstrates the successful visualization and recognition of KDM1/LSD1 antigen in a single cell using wireless bipolar electrochemiluminescence (BPE-ECL), solving the challenge of intracellular wireless visualization.

CCS CHEMISTRY (2022)

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Review Chemistry, Analytical

A Guide Inside Electrochemiluminescent Microscopy Mechanisms for Analytical Performance Improvement

Sara Rebeccani et al.

ANALYTICAL CHEMISTRY (2022)

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Article Biophysics

Confined electrochemiluminescence imaging microarray for high-throughput biosensing of single cell-released dopamine

Ningning Wang et al.

Summary: In this work, a CEIM chip was designed for high-throughput quantification of cell-secreted dopamine. The chip was able to recognize the target DA secretion from cells and emit an ECL signal without the need for additional coreactants.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Chemistry, Analytical

Surface-Sensitive Imaging Analysis of Cell-Microenvironment Interactions by Electrochemiluminescence Microscopy

Lurong Ding et al.

Summary: This work presents a surface-sensitive imaging methodology for evaluating cell-matrix adhesion differences at the single cell level and analyzing the impact of the chemical microenvironment on cell behaviors. The study reveals that different surface modifications lead to varying strengths of cell-matrix adhesion, and specific integrin subunits exhibit selective recognition to different surfaces.

ANALYTICAL CHEMISTRY (2022)

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Review Chemistry, Physical

Electrochemiluminescence microscopy: From single objects to living cells

Sara Knezevic et al.

Summary: Electrochemiluminescence (ECL) is a light-emitting phenomenon triggered by electrochemistry, which enables high-precision imaging of luminescent signals. The field of ECL is rapidly evolving from an analytical method widely used in biosensing to a novel microscopy technique. Improving electrode materials, luminophore/coreactant systems, and experimental configurations are the main focus of research.

CURRENT OPINION IN ELECTROCHEMISTRY (2022)

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Review Chemistry, Analytical

Advances in electrochemiluminescence for single-cell analysis

Qian Yang et al.

Summary: In recent years, innovative analytical methods with high sensitivity and spatiotemporal resolution have emerged for qualitative and quantitative analysis at the single-cell and subcellular levels. Among them, single-cell ECL (SCECL) analysis, with excellent spatiotemporal resolution, has become a promising tool for revealing individual cells' heterogeneity and stochastic processes.

ANALYST (2022)

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Review Electrochemistry

Recent advances in electrochemiluminescence imaging analysis

Chengda Meng et al.

Summary: Electrochemiluminescence (ECL) has distinctive features that make it widely used in imaging, including high signal-to-noise ratio, sensitivity, linear range, spatiotemporal resolution, and near-zero background light. ECL imaging technology has been applied in immunosensing, pathological cell detection, and drug analysis. Its ease of operation and ability to detect dynamic processes and catalytic sites enhance its potential in material surface and interface research, in vivo biological analysis, and cell visualization. Advancements in nanomaterials and microscopic analysis equipment have further propelled the development of high-resolution ECL imaging technology.

ESCIENCE (2022)

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Article Chemistry, Multidisciplinary

A temperature-tuned electrochemiluminescence layer for reversibly imaging cell topography

Cheng Ma et al.

Summary: This study develops a temperature-tuned ECL layer to image single cell topography at different heights by regulating the thickness of the ECL layer with electrode temperature. The ECL layer in two routes shows different regulation ranges with elevated temperature, providing a flexible approach to adjust the imaging scope within specific heights. Moreover, a heated electrode significantly improves the image quality of cell adhesion in heterogeneous electrochemical rate-determined situations. This work offers a new approach to regulate the ECL layer and has promising applications in monitoring transient heat generation from biological entities.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Dual Intramolecular Electron Transfer for In Situ Coreactant-Embedded Electrochemiluminescence Microimaging of Membrane Protein

Ningning Wang et al.

Summary: This study developed a new strategy and system using TEA-Pdots to embed coreactants in the ECL mechanism, leading to significantly improved ECL emission strength. The system can be used for in situ ECL microimaging on single living cells without the need for additional permeable treatment.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Biophysics

Enhanced electrochemiluminescence ratiometric cytosensing based on surface plasmon resonance of Au nanoparticles and nanosucculent films

Hong Zhou et al.

Summary: This study proposed a dual-potential ratiometric sensing strategy for the electrochemiluminescence detection of Ramos cells based on two types of ECL-responding molecular. The method shows low detection limit, good selectivity, and specificity through detecting ECL signal.

BIOSENSORS & BIOELECTRONICS (2021)

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Review Biotechnology & Applied Microbiology

Reflections on the organization and the physical state of chromatin in eukaryotic cells

Hilmar Strickfaden

Summary: In recent years, there has been a fundamental shift in our understanding of chromatin structure and organization in the cell nucleus, with the 30 nm chromatin fiber no longer considered essential. Advanced techniques such as Hi-C and super-resolved microscopy have revolutionized the field, offering the potential for a comprehensive understanding of nuclear functions and interactions.

GENOME (2021)

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Article Chemistry, Multidisciplinary

Super-Resolution Electrogenerated Chemiluminescence Microscopy for Single-Nanocatalyst Imaging

Ming-Ming Chen et al.

Summary: The super-resolution ECLM technique allows for high-resolution imaging of single nanoparticles' catalytic activity, revealing surface characteristics of nanocatalysts. This technology has great potential applications in catalysis, biological imaging, and single-entity analysis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Analytical

Novel gold nanoparticles functionalized Mo-polydopamine hollow sphere as an efficient quencher in conjugated microporous polymer electrochemiluminescent system

Li Song et al.

Summary: An ECL sandwich immunosensor was developed for sensitive detection of PSA, utilizing novel materials and achieving good performance, stability, and reproducibility.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Deployment of MIL-88B(Fe)/TiO2 Nanotube-Supported Ti Wires as Reusable Electrochemiluminescence Microelectrodes for Noninvasive Sensing of H2O2 from Single Cancer Cells

Xiaoxia Jian et al.

Summary: The study evaluated a high-performance solid-state ECL H2O2 sensor based on MIL-88B(Fe) nanocrystal-anchored Ti microwires, showing ultrahigh sensitivity, long-term stability, and excellent photocatalytic activity in the visible-light range at the single-cell level. The electrode demonstrated synergistic effects between the TiO2 luminophore and the peroxidase-like activity of MIL-88B(Fe), making it suitable for cytosensing applications.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

A Synergistic Coreactant for Single-Cell Electrochemiluminescence Imaging: Guanine-Rich ssDNA-Loaded High-Index Faceted Gold Nanoflowers

Ying Chen et al.

Summary: In this study, a guanine-rich DNA carrier was utilized as a synergistic coreactant for Ru(bpy)(3)(2+), achieving highly selective ECL imaging of CEA. Compared with the common coreactant tripropylamine, this novel coreactant is considered to have high performance and biocompatibility, providing exciting opportunities in single-cell imaging and detection.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Bioinspired N-C coated ZnO based electrochemiluminescence sensor for dopamine screening from neuroblastoma patient

Aqsa Munawar et al.

Summary: A novel sensing platform based on NC@ZnO was developed for precise monitoring of dopamine. The material was characterized through SEM, TEM, XPS, and Raman spectroscopy, demonstrating the successful application of the enhanced ECL intensity system for dopamine detection.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Direct imaging of single-molecule electrochemical reactions in solution

Jinrun Dong et al.

Summary: Optical imaging of single-molecule electrochemical reactions in aqueous solution enables super-resolution electrochemiluminescence microscopy, providing high spatiotemporal resolution for monitoring adhesion dynamics of live cells. Single-molecule methods go beyond ensemble averages and reveal statistical distribution of reaction positions, pathways, and dynamics, advancing fundamental understanding of electrochemical reactions and proving useful for bioassays and cell-imaging applications.

NATURE (2021)

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Review Chemistry, Multidisciplinary

Electrogenerated chemiluminescence detection of single entities

Wei Zhao et al.

Summary: Electrogenerated chemiluminescence (ECL) is a process in which light is produced by excited luminophores generated during redox reactions induced by electrochemistry. Analyzing single entities such as molecules, micro/nanoparticles, and cells using ECL can provide insights into new truths of nature that may be hidden in complex systems or averaged out in ensemble assays.

CHEMICAL SCIENCE (2021)

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Article Chemistry, Analytical

Single-cell-resolved measurement of enzyme activity at the tissue level using drop-on-demand microkits

Rongcan Huang et al.

Summary: Using drop-on-demand microkits with a diameter of around 20 μm, the activity of acetylcholinesterase (AChE) in a brain slice is measured at single-cell resolution, showing a high relative standard deviation of 73.3% among 25 cellular regions. This approach offers an alternative strategy for exploring enzymatic heterogeneity at the tissue level with single-cell resolution.

ANALYST (2021)

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Article Chemistry, Multidisciplinary

Imaging Cell-Matrix Adhesions and Collective Migration of Living Cells by Electrochemiluminescence Microscopy

Hao Ding et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Analytical

Single Cell Electrochemiluminescence Analysis of Cholesterol in Plasma Membrane during Testosterone Treatment

Linyu Li et al.

ELECTROANALYSIS (2020)

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Article Chemistry, Analytical

Electrochemiluminescence Imaging for the Morphological and Quantitative Analysis of Living Cells under External Stimulation

Hongfang Gao et al.

ANALYTICAL CHEMISTRY (2020)

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Review Chemistry, Multidisciplinary

Electrochemiluminescence Single-Cell Analysis: Intensity- and Imaging-Based Methods

Hao Ding et al.

CHEMPLUSCHEM (2020)

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Article Chemistry, Multidisciplinary

Electrochemiluminescence Biosensor for Nucleolin Imaging in a Single Tumor Cell Combined with Synergetic Therapy of Tumor

Wanxia Gao et al.

ACS SENSORS (2020)

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Article Chemistry, Multidisciplinary

Monitoring casein kinase II at subcellular level via bio-bar-code-based electrochemiluminescence biosensing method

Lifen Wang et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Chemistry, Physical

Understanding the ECL interaction of luminol and Ru(bpy)32+ luminophores by spectro-electrochemiluminescence

David Ibanez et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2020)

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Article Chemistry, Analytical

Electrochemiluminescence Analysis of Hydrogen Peroxide Using L012 Modified Electrodes

Yuling Wang et al.

JOURNAL OF ANALYSIS AND TESTING (2020)

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Article Chemistry, Multidisciplinary

Observing the structure-dependent electrocatalytic activity of bimetallic Pd-Au nanorods at the single-particle level

Ming-Ming Chen et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Analytical

Potential-Resolved Electrochemiluminescence Nanoprobes for Visual Apoptosis Evaluation at Single-Cell Level

Gen Liu et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Phosphate Assay Kit in One Cell for Electrochemical Detection of Intracellular Phosphate Ions at Single Cells

Haiyan Xu et al.

FRONTIERS IN CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

From single bacterial cell imaging towards in vivo single-molecule biochemistry studies

Ulrike Endesfelder

SINGLE CELL BIOLOGY (2019)

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Article Chemistry, Multidisciplinary

Electrochemiluminescence-Based Capacitance Microscopy for Label-Free Imaging of Antigens on the Cellular Plasma Membrane

Jingjing Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Analytical

Electrochemiluminescence-Microscopy for microRNA Imaging in Single Cancer Cell Combined with Chemotherapy-Photothermal Therapy

Huairong Zhang et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Codetermination of Sphingomyelin and Cholesterol in Cellular Plasma Membrane in Sphingomyelin-Depletion-Induced Cholesterol Efflux

Shuohan Huang et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Steady-State Electrochemiluminescence at Single Senniconductive Titanium Dioxide Nanoparticles for Local Sensing of Single Cells

Chen Cui et al.

ANALYTICAL CHEMISTRY (2019)

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Article Electrochemistry

Confined electrochemiluminescence in vertically ordered silica mesochannels for the imaging of hydrogen peroxide released from single cells

Jingjing Zhang et al.

ELECTROCHEMISTRY COMMUNICATIONS (2019)

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Article Biochemical Research Methods

Gold-coated polydimethylsiloxane microwells for high-throughput electrochemiluminescence analysis of intracellular glucose at single cells

Juan Xia et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018)

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Article Chemistry, Analytical

Direct Electrochemiluminescence Imaging of a Single Cell on a Chitosan Film Modified Electrode

Gen Liu et al.

ANALYTICAL CHEMISTRY (2018)

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Article Chemistry, Analytical

Cholesterol Oxidase/Triton X-100 Parked Microelectrodes for the Detection of Cholesterol in Plasma Membrane at Single Cells

Haiyan Xu et al.

ANALYTICAL CHEMISTRY (2018)

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Review Chemistry, Multidisciplinary

New Frontiers and Challenges for Single-Cell Electrochemical Analysis

Jingjing Zhang et al.

ACS SENSORS (2018)

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Article Chemistry, Analytical

Immuno-Electrochemiluminescent Imaging of a Single Cell Based on Functional Nanoprobes of Heterogeneous Ru(bpy)32+@SiO2/Au Nanoparticles

Jun-Tao Cao et al.

ANALYTICAL CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

A high precision MUA-spaced single-cell sensor for cellular receptor assay based on bifunctional Au@Cu-PbCQD nanoprobes

Dongping Long et al.

NANOSCALE (2018)

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Review Cell Biology

Microfluidics-based on-a-chip systems for isolating and analysing extracellular vesicles

Shang-Chun Guo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Review Chemistry, Analytical

Recent Advances in Electrochemiluminescence Analysis

Lingling Li et al.

ANALYTICAL CHEMISTRY (2017)

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Article Chemistry, Multidisciplinary

Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis

Giovanni Valenti et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Biochemical Research Methods

Quantitative analyses of the 3D nuclear landscape recorded with super-resolved fluorescence microscopy

Volker J. Schmid et al.

METHODS (2017)

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Article Chemistry, Analytical

Nanoscale polypyrrole sensors for near-field electrochemical measurements

Vinithra Venugopal et al.

SENSORS AND ACTUATORS B-CHEMICAL (2017)

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Article Chemistry, Multidisciplinary

A novel metal-organic framework loaded with abundant N-(aminobutyl)-N-(ethylisoluminol) as a high-efficiency electrochemiluminescence indicator for sensitive detection of mucin1 on cancer cells

Xinya Jiang et al.

CHEMICAL COMMUNICATIONS (2017)

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Article Nanoscience & Nanotechnology

Novel Single-Cell Analysis Platform Based on a Solid-State Zinc-Coadsorbed Carbon Quantum Dots Electrochemiluminescence Probe for the Evaluation of CD44 Expression on Breast Cancer Cells

Youyi Qiu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Chemistry, Analytical

Imaging Analysis Based on Electrogenerated Chemiluminescence

Weiliang Guo et al.

JOURNAL OF ANALYSIS AND TESTING (2017)

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C3N4 Nanosheet Modified Microwell Array with Enhanced Electrochemiluminescence for Total Analysis of Cholesterol at Single Cells

Jingjing Xu et al.

ANALYTICAL CHEMISTRY (2017)

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Article Electrochemistry

Ultrasensitive electrochemiluminescence biosensor for organophosphate pesticides detection based on carboxylated graphitic carbon nitride-poly(ethylenimine) and acetylcholinesterase

Bingxin Wang et al.

ELECTROCHIMICA ACTA (2017)

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Review-Electrogenerated Chemiluminescence: Light Years Ahead

Mahdi Hesari et al.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2016)

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Electrochemical Visualization of Intracellular Hydrogen Peroxide at Single Cells

Ruiqin He et al.

ANALYTICAL CHEMISTRY (2016)

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Article Chemistry, Analytical

Analysis of Intracellular Glucose at Single Cells Using Electrochemiluminescence Imaging

Jingjing Xu et al.

ANALYTICAL CHEMISTRY (2016)

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A rapid and sensitive electrochemiluminescent sensor for nitrites based on C3N4 quantum dots on C3N4 nanosheets

Xi Zhu et al.

RSC ADVANCES (2016)

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Review Electrochemistry

Essential Role of Electrode Materials in Electrochemiluminescence Applications

Giovanni Valenti et al.

CHEMELECTROCHEM (2016)

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Article Chemistry, Analytical

Electrochemiluminescence Imaging for Parallel Single-Cell Analysis of Active Membrane Cholesterol

Junyu Zhou et al.

ANALYTICAL CHEMISTRY (2015)

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Article Chemistry, Analytical

Fast Serial Analysis of Active Cholesterol at the Plasma Membrane in Single Cells

Chunxiu Tian et al.

ANALYTICAL CHEMISTRY (2014)

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Allen J. Bard

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 7 (2014)

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Article Chemistry, Multidisciplinary

Visual electrochemiluminescence detection of telomerase activity based on multifunctional Au nanoparticles modified with G-quadruplex deoxyribozyme and luminol

Huai-Rong Zhang et al.

CHEMICAL COMMUNICATIONS (2014)

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Luminol Electrochemiluminescence for the Analysis of Active Cholesterol at the Plasma Membrane in Single Mammalian Cells

Guangzhong Ma et al.

ANALYTICAL CHEMISTRY (2013)

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Molecular and Functional Analysis of Cellular Phenomena Using Single-Cell Mass Spectrometry

Naohiro Tsuyama et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2012)

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Electrogenerated Chemiluminescence Emissions from CdS Nanoparticles for Probing of Surface Oxidation

Yi-Min Fang et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2011)

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Article Nanoscience & Nanotechnology

Characterization of nanoprobe uptake in single cells: spatial and temporal tracking via SERS labeling and modulation of surface charge

Molly K. Gregas et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

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In vivo electrochemical impedance measurement on single cell membrane

Seoung-Jai Bai et al.

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Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response Signaling asymmetry and an extension of chemical neuroanatomy

James Eberwine et al.

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Review Chemistry, Multidisciplinary

Applications and trends in electrochemiluminescence

Lianzhe Hu et al.

CHEMICAL SOCIETY REVIEWS (2010)

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Multiplexed Sandwich Immunoassays Using Electrochemiluminescence Imaging Resolved at the Single Bead Level

Frederique Deiss et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

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Review Chemistry, Multidisciplinary

Electrochemiluminescence (ECL)

MM Richter

CHEMICAL REVIEWS (2004)

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Article Chemistry, Multidisciplinary

Electrogenerated chemiluminescence 69:: The tris(2,2′-bipyridine)ruthenium(II), (Ru(bpy)32+)/tri-n-propylamine (TPrA) system revisited -: A new route involving TPrA•+ cation radicals

WJ Miao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

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Article Chemistry, Analytical

A wireless electrochemiluminescence detector applied to direct and indirect detection for electrophoresis on a microfabricated glass device

A Arora et al.

ANALYTICAL CHEMISTRY (2001)

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Article Chemistry, Analytical

Scanning optical microscopy with an electrogenerated chemiluminescent light source at a nanometer tip

YB Zu et al.

ANALYTICAL CHEMISTRY (2001)

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