期刊
BIOSENSORS-BASEL
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/bios13060642
关键词
conjugated polymer; nanotheranostics; photothermal therapy; NIR-II; nitric oxide
The researchers developed a nanotheranostics, CPNPBs, activated by second near-infrared (NIR-II) light. It utilizes a thermosensitive nitric oxide (NO) donor to enhance photothermal therapy and inhibit inflammation. This approach holds great promise for potential clinical development of NO-enhanced photothermal therapy.
Photothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated nanotheranostics (CPNPBs), which include a thermosensitive nitric oxide (NO) donor (BNN6) to enhance PTT. Under a 1064 nm laser irradiation, the conjugated polymer in CPNPBs serves as a photothermal agent for photothermal conversion, and the generated heat triggers the decomposition of BNN6 to release NO. The combination of hyperthermia and NO generation under single NIR-II laser irradiation allows enhanced thermal ablation of tumors. Consequently, CPNPBs can be exploited as potential candidates for NO-enhanced PTT, holding great promise for their clinical translational development.
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