期刊
TOXICS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/toxics11040338
关键词
anti-seizure medication (ASM); Eurasian otter; top predator; pollution; biota monitoring; pharmaceuticals
Emerging contaminants, including substances in anti-seizure medication, are being increasingly found in surface waters in Germany, with unknown consequences for aquatic wildlife. The Eurasian otter, a top predator, can be an indicator species for environmental pollutants. Brain samples of otters were screened for anti-seizure medication using advanced analytical techniques, but no targeted substances were detected. However, unidentified substances were found in the otter brains, and further investigation is hindered by sample quality limitations.
Emerging contaminants are produced globally at high rates and often ultimately find their way into the aquatic environment. These include substances contained in anti-seizure medication (ASM), which are currently appearing in surface waters at increasing concentrations in Germany. Unintentional and sublethal, chronic exposure to pharmaceuticals such as ASMs has unknown consequences for aquatic wildlife. Adverse effects of ASMs on the brain development are documented in mammals. Top predators such as Eurasian otters (Lutra lutra) are susceptible to the bioaccumulation of environmental pollutants. Still little is known about the health status of the otter population in Germany, while the detection of various pollutants in otter tissue samples has highlighted their role as an indicator species. To investigate potential contamination with pharmaceuticals, Eurasian otter brain samples were screened for selected ASMs via high-performance liquid chromatography and mass spectrometry. Via histology, brain sections were analyzed for the presence of potential associated neuropathological changes. In addition to 20 wild otters that were found dead, a control group of 5 deceased otters in human care was studied. Even though none of the targeted ASMs were detected in the otters, unidentified substances in many otter brains were measured. No obvious pathology was observed histologically, although the sample quality limited the investigations.
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