Refueling the post COVID-19 brain: potential role of ketogenic medium chain triglyceride supplementation: an hypothesis

Article Biochemistry & Molecular Biology

β-Hydroxybutyrate and Medium-Chain Fatty Acids are Metabolized by Different Cell Types in Mouse Cerebral Cortex Slices

Jens Andersen et al.

Summary: Ketogenic diets and medium-chain triglycerides play important roles in the treatment of neurological disorders, with their metabolites serving as auxiliary brain fuels in different cell types without notable competition.

NEUROCHEMICAL RESEARCH (2023)

添加到收藏夹

Review Clinical Neurology

Impact of COVID-19 on the Onset and Progression of Alzheimer's Disease and Related Dementias: A Roadmap for Future Research

Marcia N. Gordon et al.

Summary: COVID-19 infection may increase the risk of cognitive impairment, so further research is needed to study the symptoms, genetic polymorphisms, and treatment decisions associated with cognitive impairment risk, and to establish research consortia to monitor long-term consequences. Additionally, the lack of model systems to test hypotheses related to infection and cognition is a pending issue.

ALZHEIMERS & DEMENTIA (2022)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Neuropsychologic Profiles and Cerebral Glucose Metabolism in Neurocognitive Long COVID Syndrome

Andrea Dressing et al.

Summary: During the long-term phase after COVID-19 infection, patients may experience cognitive deficits and fatigue. In this study, cognitive testing and brain glucose metabolism imaging showed minor impairments in cognitive domains and no distinct pathological changes. This differs from previous findings in subacute COVID-19 patients and may be related to the high prevalence of fatigue.

JOURNAL OF NUCLEAR MEDICINE (2022)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review

Philipp T. Meyer et al.

Summary: This study systematically reviewed the current literature on how COVID-19 affects the human brain using molecular imaging techniques like PET and SPECT. The findings include reversible metabolic alterations, Parkinsonism symptoms, hyposmia, encephalopathy, and post-COVID-19 syndrome, with potential applications of PET and SPECT in diagnostic work-up related to COVID-19.

JOURNAL OF NUCLEAR MEDICINE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

Douglas B. Kell et al.

Summary: Post-acute sequelae of COVID, commonly known as Long COVID, is a frequent consequence of SARS-CoV-2 infection. Fibrin amyloid microclots may underpin the majority of symptoms by blocking capillaries and limiting oxygen exchange.

BIOCHEMICAL JOURNAL (2022)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Similar patterns of [18F]-FDG brain PET hypometabolism in paediatric and adult patients with long COVID: a paediatric case series

Aurelie Morand et al.

Summary: Despite lower initial severity at the acute stage of infection, pediatric patients with suspected long COVID showed a similar brain hypometabolic pattern as adult long COVID patients approximately 5 months later, involving bilateral medial temporal lobes, brainstem, cerebellum, and the right olfactory gyrus.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

添加到收藏夹

Review Immunology

Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review

Chen Chen et al.

Summary: This study reveals a substantial prevalence of post-COVID-19 condition worldwide. Hospitalized patients have a higher prevalence compared to non-hospitalized ones. Fatigue is the most commonly reported symptom.

JOURNAL OF INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Neurosciences

Inflammation at the crossroads of COVID-19, cognitive deficits and depression

Natalia M. Lyra e Silva et al.

Summary: COVID-19 infection is associated with acute neurological alterations and long-term neurological abnormalities, with ongoing research investigating the mechanisms behind these impacts, particularly neuroinflammation and blood-brain barrier dysfunction. Survivors of COVID-19 may have an increased risk of developing dementia and mood disorders.

NEUROPHARMACOLOGY (2022)

添加到收藏夹

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

2-[18F]-FDG PET for imaging brain involvement in patients with long COVID: perspective of the EANM Neuroimaging Committee

Antoine Verger et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Persistence of Metabolomic Changes in Patients during Post-COVID Phase: A Prospective, Observational Study

Peter Liptak et al.

Summary: This study reveals metabolic changes in COVID-19 patients during the acute infection and one month after, indicating a persistent effect of the virus on metabolism. The random forest algorithm shows great discrimination between patients and controls based on metabolite levels.

METABOLITES (2022)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Time-dependent recovery of brain hypometabolism in neuro-COVID-19 patients

Anna Lisa Martini et al.

Summary: This study evaluated brain metabolic dysfunctions in different phases of COVID-19 and found that hypometabolism in the fronto-insular cortex is associated with cognitive dysfunction, low blood oxygen levels, and high inflammation. Long-lasting brain hypermetabolism in the brainstem, cerebellum, hippocampus, and amygdala seems to reflect persistent inflammation processes.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

添加到收藏夹

Article Pathology

The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection*

Gerard J. Nuovo et al.

Summary: Pre-existing Alzheimer's disease is a risk factor for severe/fatal COVID-19, and infection by SARS-CoV2 may worsen Alzheimer's disease through multiple mechanisms. This study analyzed molecular changes in brain tissues of COVID-19 patients with and without pre-existing dementia, and found that SARS-CoV2 may amplify Alzheimer's disease by modulating protein expression and inducing microangiopathy and microglial activation.

ANNALS OF DIAGNOSTIC PATHOLOGY (2022)

添加到收藏夹

Article Immunology

Long-term cognitive performance and its relation to anti-inflammatory therapy in a cohort of survivors of severe COVID-19

Harmke B. Duindam et al.

Summary: A relevant proportion of critically ill COVID-19 patients exhibit deficits in long-term cognitive functioning. Anti-inflammatory therapy does not seem to affect long-term cognitive performance, except for more pronounced executive dysfunction. Additionally, subjective cognitive complaints are associated with patient gender and ICU stay duration.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2022)

添加到收藏夹

Article Clinical Neurology

Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double-blind, placebo-controlled, crossover study, with an open-label extension

Angela G. G. Juby et al.

Summary: This study observed the long-term use of MCT oil in Alzheimer's disease patients and found that 80% of patients had stable or improved cognition. Long-term use of MCT oil and age over 73 years had a positive effect on improving final cognitive function.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2022)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?

E. Guedj et al.

Summary: Several brain complications have been reported in COVID-19 patients, suggesting potential neurotropism and delayed outbreak of neuroinflammatory diseases. PET metabolism analysis showed hypometabolism in the olfactory/rectus gyrus and other brain regions, supporting the neurotropism hypothesis. Further post-viral cohort studies are needed to determine the exact relationship between these hypometabolisms and persistent disorders.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

添加到收藏夹

Letter Clinical Neurology

Frontal encephalopathy related to hyperinflammation in COVID-19

Ilaria Cani et al.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Assessment and characterisation of post-COVID-19 manifestations

Marwa Kamal et al.

Summary: The study found that the majority of COVID-19 survivors experience post-viral symptoms, with fatigue being the most common, and some experiencing severe complications such as stroke and myocarditis. The presence of comorbidities prior to COVID-19 infection is related to the severity of post-COVID-19 manifestations.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

添加到收藏夹

Article

SARS-CoV-2 (COVID-19) as a Predictor of Neuroinflammation and Neurodegeneration: Potential Treatment Strategies

M. V. Putilina et al.

Neuroscience and Behavioral Physiology (2021)

添加到收藏夹

Article Nutrition & Dietetics

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease

Patrycja Puchalska et al.

Annual Review of Nutrition (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

Aurelie Kas et al.

Summary: This study examined the longitudinal brain metabolic pattern in COVID-19-related encephalopathy using 18F-FDG-PET/CT. It found a consistent pattern of hypometabolism in various brain regions, with patients presenting with cognitive and behavioral disorders in the acute phase and ongoing cognitive and emotional symptoms 6 months after disease onset.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDG brain PET hypometabolism in patients with long COVID

E. Guedj et al.

Summary: In long COVID patients, brain PET scans showed significant hypometabolism in areas including bilateral rectal/orbital gyrus, temporal lobe, brainstem, and cerebellum. These metabolic abnormalities were associated with more functional complaints such as hyposmia/anosmia, memory/cognitive impairment, pain, and insomnia. The study suggests a potential biomarker value in identifying and monitoring long COVID patients, with implications for the impact of ACE drugs and nasal decongestant spray on brain metabolism.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.

Etienne Myette-Cote et al.

Summary: This study found that a 6-month intervention with kMCT had minimal effect on cardiometabolic markers and peripheral inflammation in individuals with mild cognitive impairment (MCI).

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2021)

添加到收藏夹

Article Medicine, General & Internal

Obesity is associated with a greater number of long-term post-COVID symptoms and poor sleep quality: A multicentre case-control study

Cesar Fernandez-de-Las-Penas et al.

Summary: This study found that obesity was associated with a greater number of long-term post-COVID symptoms and poor sleep quality in hospitalised COVID-19 patients, but no significant difference was observed between people with and without obesity in the prevalence of fatigue, dyspnea, anxiety, depression, and limitations of daily living activities.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

添加到收藏夹

Editorial Material Medicine, Research & Experimental

Selective Neuronal Mitochondrial Targeting in SARS- CoV-2 Infection Affects Cognitive Processes to Induce 'Brain Fog' and Results in Behavioral Changes that Favor Viral Survival

George B. Stefano et al.

Summary: Alterations in brain functioning due to SARS-CoV-2 infection and COVID-19 can result in long-term mental and cognitive changes, including symptoms like "brain fog". Hypoxia in certain brain areas may benefit the virus's reproductive capacity, causing dysfunction in neurons with high oxygen demand, leading to cognitive impairment and behaviors that favor viral spread.

MEDICAL SCIENCE MONITOR (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis

Shin Jie Yong

Summary: Long-COVID is a postviral illness that can affect survivors of COVID-19, potentially caused by long-term tissue damage, viral persistence, and dysfunction of the brainstem. The brainstem plays a crucial role in manifesting symptoms, including respiratory, cardiovascular, and neurological functions, thus potentially linking it to long-COVID.

ACS CHEMICAL NEUROSCIENCE (2021)

添加到收藏夹

Article Hematology

COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies

Eleonora Calabretta et al.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study

Martina Sollini et al.

Summary: The study hypothesized that whole-body [18F]FDG-PET/CT could provide insight into the pathophysiology of long COVID. Results revealed increased [18F]FDG uptake in various organs of long COVID patients, suggesting underlying systemic inflammation. Brain hypometabolism patterns were associated with persistent symptoms, indicating different temporal sequences of brain and whole-body inflammatory changes. Whole-body [18F]FDG PET was found to hold potential value in disclosing the pathophysiology of long COVID.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

添加到收藏夹

Article Nutrition & Dietetics

ASPEN lipid injectable emulsion safety recommendations part 2: Neonate and pediatric considerations

M. Petrea Cober et al.

Summary: ILE use in neonatal and pediatric patients differs from that in adults, often requiring higher doses for growth and development. It is frequently administered separately due to compatibility issues and limited IV access. Concerns exist with in-line filters and repackaging of commercial products, and adverse effects may occur with doses exceeding recommendations.

NUTRITION IN CLINICAL PRACTICE (2021)

添加到收藏夹

Article Clinical Neurology

Cognitive impairment and a ered cerebral glucose metabolism in the subacute stage of COVID-19

Jonas A. Hosp et al.

Summary: During the COVID-19 pandemic, a prospective cohort study investigated neurological and cognitive symptoms in hospitalized patients, revealing that gustation and olfaction were commonly affected, along with cognitive impairment. Abnormalities in neuronal metabolism were associated with cognitive decline, highlighting the importance of neurological monitoring in COVID-19 patients.

BRAIN (2021)

添加到收藏夹

Letter Radiology, Nuclear Medicine & Medical Imaging

About the source and consequences of 18F-FDG brain PET hypometabolism in short and long COVID-19

Igor C. Fontana et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

添加到收藏夹

Article Clinical Neurology

Neurological update: COVID-19

A. L. Ren et al.

Summary: COVID-19 is primarily a respiratory disease, but can also lead to neurological complications. The main processes causing neurological damage include cerebrovascular disease, immunologically mediated neurological disorders, and the harmful effects of critical illness on the nervous system. While it is still uncertain if the virus directly invades the nervous system, the large number of infections at present suggests that nervous system infection may not be a significant issue.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

SARS-CoV-2-related encephalitis with prominent parkinsonism: clinical and FDG-PET correlates in two patients

Mauro Morassi et al.

Summary: This study presents the clinical and neuroimaging findings of two patients with COVID-19-related encephalopathy and prominent parkinsonism, suggesting a possible immune-mediated etiology in one case. Despite the lack of response to immunotherapy, FDG-PET/CT results displayed distinctive brain metabolic changes reminiscent of post-encephalitic parkinsonism, highlighting the neurological complications possibly triggered by SARS-CoV-2 infection.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients

Ganna Blazhenets et al.

Summary: Cognitive impairment in COVID-19 patients can be related to cortical hypometabolism, which shows reversibility after 6 months. Despite significant recovery, residual impairments remain in some patients.

JOURNAL OF NUCLEAR MEDICINE (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel

Wael Al Mahmeed et al.

Summary: Efforts in fighting against COVID-19 have shown success in many parts of the world, and a syndemic approach is needed to address this pandemic. The international CAPISCO team aims to promote this approach and facilitate collaboration between researchers and clinicians worldwide.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Article Clinical Neurology

Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 long haulers

Edith L. Graham et al.

Summary: This study investigated the neurologic manifestations in non-hospitalized Covid-19 long haulers, revealing prominent symptoms such as brain fog and fatigue which negatively affect their cognition and quality of life.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

Sherry H. -Y. Chou et al.

Summary: This study included patients with clinically diagnosed or laboratory-confirmed COVID-19 at 28 centers across 13 countries and 4 continents from March 1 to September 30, 2020. Neurological manifestations were prevalent among hospitalized patients with COVID-19 and were associated with higher in-hospital mortality. Patients with preexisting neurological disorders were at increased risk of developing neurological signs and/or syndromes in COVID-19.

JAMA NETWORK OPEN (2021)

添加到收藏夹

Review Clinical Neurology

Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies

Felicity Y. Han et al.

Summary: Impaired glucose metabolism in epileptic brain areas can lead to seizures, while using auxiliary brain fuels such as ketone bodies may be beneficial for epilepsy patients.

EPILEPSIA (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Jia Ying Brenda Tan et al.

Summary: The utilization of lipid nanoparticles to deliver fatty acids and monoglycerides for treating medical diseases shows promising potential, with a focus on understanding the relationship between nanoparticle structure and biological function. Opportunities for translation and regulatory needs are discussed, highlighting unmet clinical opportunities.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Clinical Neurology

Long-term neurological manifestations of COVID-19: prevalence and predictive factors

Andrea Pilotto et al.

Summary: Long-term neurological manifestations have been observed in both hospitalised and non-hospitalised COVID-19 patients. Factors such as age, comorbidities, and severity of SARS-CoV-2 infection are independent predictors of long-term neurological symptoms in survivors after 6 months of hospitalisation.

NEUROLOGICAL SCIENCES (2021)

添加到收藏夹

Article Clinical Neurology

K.Vita: a feasibility study of a blend of medium chain triglycerides to manage drug-resistant epilepsy

Natasha E. Schoeler et al.

Summary: This study evaluated the acceptability, tolerability, and compliance of dietary intervention with K.Vita in individuals with drug-resistant epilepsy. The results showed that K.Vita was well accepted and tolerated, and may have a beneficial effect on reducing the frequency of seizures. Further research on the effectiveness of K.Vita is warranted.

BRAIN COMMUNICATIONS (2021)

添加到收藏夹

Review Medicine, General & Internal

COVID-19 and Alzheimer's Disease: A Literature Review

Louis Hardan et al.

Summary: This article explores the link between COVID-19 and Alzheimer's disease, discussing the direct and indirect impact of COVID-19 on individuals with Alzheimer's disease.

MEDICINA-LITHUANIA (2021)

添加到收藏夹

Review Rheumatology

Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

Moon Ley Tung et al.

Summary: The COVID-19 pandemic has caused widespread mortality globally, with a high prevalence of thromboembolic events and the presence of aPLs in patients. Similarities between COVID-19 and APS suggest a potential role of therapeutic targets based on the anti-phospholipid model in managing the disease.

RHEUMATOLOGY ADVANCES IN PRACTICE (2021)

添加到收藏夹

Article Medicine, General & Internal

The COVID-19 Sequelae: A Cross-Sectional Evaluation of Post-recovery Symptoms and the Need for Rehabilitation of COVID-19 Survivors

Ayman Iqbal et al.

Summary: The study assessed the prevalence and characteristics of post-COVID-19 manifestations and their impact on the quality of life of recovered individuals. Findings showed that a vast majority experienced at least one post-COVID-19 symptom, with fatigue being the most common. There was a significant correlation between post-COVID-19 symptoms and factors like gender, age, time since recovery, and severity of COVID-19.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

添加到收藏夹

Article Clinical Neurology

Assessing the Impact of Factors that Influence the Ketogenic Response to Varying Doses of Medium Chain Triglyceride (MCT) Oil

Angela G. Juby et al.

Summary: This study found significant inter-individual variability in BHB response to MCT oil intake, influenced by various factors such as visceral fat, BMI, waist/hip ratio, and nutrient content of pre-study meals. This highlights the challenges in interpreting clinical responses to MCT intake across different age groups and health statuses.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2021)

添加到收藏夹

Article Clinical Neurology

A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT

Melanie Fortier et al.

Summary: Supplementation with ketogenic medium chain triglyceride (kMCT) drink significantly improved cognitive outcomes in mild cognitive impairment (MCI), possibly by increasing blood ketone levels. These data support further evaluation of MCI progression to Alzheimer's disease.

ALZHEIMERS & DEMENTIA (2021)

添加到收藏夹

Article Nutrition & Dietetics

Medium-chain triglycerides improved cognition and lipid metabolomics in mild to moderate Alzheimer's disease patients with APOE4-/-: A double-blind, randomized, placebo-controlled crossover trial

Qing Xu et al.

CLINICAL NUTRITION (2020)

添加到收藏夹

Review Cell Biology

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies

Konstantinos I. Avgerinos et al.

AGEING RESEARCH REVIEWS (2020)

添加到收藏夹

Review Virology

The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients

Yan-Chao Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

添加到收藏夹

Review Virology

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

Marc Desforges et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig et al.

ACS CHEMICAL NEUROSCIENCE (2020)

添加到收藏夹

Article Clinical Neurology

Steroid-Responsive Encephalitis in Coronavirus Disease 2019

Andrea Pilotto et al.

ANNALS OF NEUROLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

COVID-19 infection may cause ketosis and ketoacidosis

Juyi Li et al.

DIABETES OBESITY & METABOLISM (2020)

添加到收藏夹

Article Critical Care Medicine

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

Julie Helms et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Article Clinical Neurology

Two Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis

Guillaume Dorcet et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Article Neurosciences

The involvement of the central nervous system in patients with COVID-19

Kiarash Saleki et al.

REVIEWS IN THE NEUROSCIENCES (2020)

添加到收藏夹

Review Clinical Neurology

Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?

P. J. Serrano-Castro et al.

NEUROLOGIA (2020)

添加到收藏夹

Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

Keshav K. Singh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

添加到收藏夹

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

COVID-19 and the brain: impact on nuclear medicine in neurology

Silvia Morbelli et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

添加到收藏夹

Article Cell Biology

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Ana Campos Codo et al.

CELL METABOLISM (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study

Naomi Holman et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

Kevin E. Wu et al.

CELL SYSTEMS (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Stephen C. Cunnane et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

添加到收藏夹

Article Clinical Neurology

COVID-19-related encephalopathy: a case series with brain FDG-positron-emission tomography/computed tomography findings

C. Delorme et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

The BMJ interview: Anthony Fauci on covid-19

Fiona Godlee et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Obesity, Diabetes and COVID-19: An Infectious Disease Spreading From the East Collides With the Consequences of an Unhealthy Western Lifestyle

Jeff M. P. Holly et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Nicole Jacqueline Jensen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Clinical Neurology

COVID-19 and cerebrovascular diseases: a comprehensive overview

Georgios Tsivgoulis et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Long-Term Respiratory and Neurological Sequelae of COVID-19

Fuzhou Wang et al.

MEDICAL SCIENCE MONITOR (2020)

添加到收藏夹

Article Critical Care Medicine

Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients

Julie Helms et al.

CRITICAL CARE (2020)

添加到收藏夹

Article Medicine, General & Internal

Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy

Asia Filatov et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

添加到收藏夹

Article Nutrition & Dietetics

Medium Chain Triglycerides Modulate the Ketogenic Effect of a Metabolic Switch

Camille Vandenberghe et al.

FRONTIERS IN NUTRITION (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)

M. Caprio et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2019)

添加到收藏夹

Article Neurosciences

Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease

Miho Ota et al.

NEUROSCIENCE LETTERS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Astrocyte Biomarkers in Alzheimer's Disease

Stephen F. Carter et al.

TRENDS IN MOLECULAR MEDICINE (2019)

添加到收藏夹

Review Medicine, General & Internal

Effects of Intermittent Fasting on Health, Aging, and Disease

Rafael de Cabo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Article Nutrition & Dietetics

Plasma Ketone and Medium Chain Fatty Acid Response in Humans Consuming Different Medium Chain Triglycerides During a Metabolic Study Day

Valerie St-Pierre et al.

FRONTIERS IN NUTRITION (2019)

添加到收藏夹

Article Clinical Neurology

Evidence for brain glucose dysregulation in Alzheimer's disease

Yang An et al.

ALZHEIMERS & DEMENTIA (2018)

添加到收藏夹

Review Neurosciences

Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

Jennifer C. Felger

CURRENT NEUROPHARMACOLOGY (2018)

添加到收藏夹

Article Geriatrics & Gerontology

A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease

E. Croteau et al.

EXPERIMENTAL GERONTOLOGY (2018)

添加到收藏夹

Article Neurosciences

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer's Disease

Etienne Croteau et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

添加到收藏夹

Article Neurosciences

Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function

Shirin Hosseini et al.

JOURNAL OF NEUROSCIENCE (2018)

添加到收藏夹

Review Clinical Neurology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Steven E. Arnold et al.

NATURE REVIEWS NEUROLOGY (2018)

添加到收藏夹

Review Neurosciences

Evidence for altered insulin receptor signaling in Alzheimer's disease

Chelsea M. Griffith et al.

NEUROPHARMACOLOGY (2018)

添加到收藏夹

Review Behavioral Sciences

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure

Tamara E. Lacourt et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2018)

添加到收藏夹

Article Nutrition & Dietetics

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Lijing Xin et al.

FRONTIERS IN NUTRITION (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study

Alexandre Courchesne-Loyer et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

添加到收藏夹

Review Neurosciences

Cerebral Hypoperfusion and Glucose Hypometabolism: Key Pathophysiological Modulators Promote Neurodegeneration, Cognitive Impairment, and Alzheimer's Disease

Mak Adam Daulatzai

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

Lavanya B. Achanta et al.

NEUROCHEMICAL RESEARCH (2017)

添加到收藏夹

Article Endocrinology & Metabolism

2-18F-fluoro-2-deoxyglucose positron emission tomography in delirium

Lucy R. Haggstrom et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDG PET in Parkinsonism: Differential Diagnosis and Evaluation of Cognitive Impairment

Philipp T. Meyer et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

添加到收藏夹

Article Neurosciences

[18F]FDG PET signal is driven by astroglial glutamate transport

Eduardo R. Zimmer et al.

NATURE NEUROSCIENCE (2017)

添加到收藏夹

Editorial Material Neurosciences

Glucose utilization: still in the synapse

A. Jon Stoessl

NATURE NEUROSCIENCE (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Hepatitis C virus infection, and neurological and psychiatric disorders - A review

Lydia Yarlott et al.

JOURNAL OF ADVANCED RESEARCH (2017)

添加到收藏夹

Article Infectious Diseases

Cerebral glucose hypometabolism in Tick-Borne Encephalitis, a pilot study in 10 Patients

Anelia Dietmann et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Fatty acids and their therapeutic potential in neurological disorders

Enie Lei et al.

NEUROCHEMISTRY INTERNATIONAL (2016)

添加到收藏夹

Article Geriatrics & Gerontology

Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer's disease: a prospective, open-label pilot study

Tohru Ohnuma et al.

CLINICAL INTERVENTIONS IN AGING (2016)

添加到收藏夹

Article Neurosciences

Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease

Stephen C. Cunnane et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

添加到收藏夹

Article Clinical Neurology

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

Mary T. Newport et al.

ALZHEIMERS & DEMENTIA (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

Sean David Hughes et al.

JOURNAL OF NEUROCHEMISTRY (2014)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Ketone body metabolism and cardiovascular disease

David G. Cotter et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

添加到收藏夹

Article Geriatrics & Gerontology

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

Yoshihiro Kashiwaya et al.

NEUROBIOLOGY OF AGING (2013)

添加到收藏夹

Editorial Material Cell Biology

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

Sung Min Son et al.

AUTOPHAGY (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

Peter Wurtz et al.

DIABETES (2012)

添加到收藏夹

Article Neurosciences

Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice

Piotr Wlaz et al.

NEUROPHARMACOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

Latha Devi et al.

PLOS ONE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity

Kendra L. Puig et al.

PLOS ONE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Brain and systemic glucose metabolism in the healthy elderly following fish oil supplementation

S. Nugent et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2011)

添加到收藏夹

Review Neurosciences

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

Marwan Maalouf et al.

BRAIN RESEARCH REVIEWS (2009)

添加到收藏夹

Article Endocrinology & Metabolism

Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

Kathleen A. Page et al.

DIABETES (2009)

添加到收藏夹

Article Endocrinology & Metabolism

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

Bhumsoo Kim et al.

ENDOCRINOLOGY (2009)

添加到收藏夹

Article Nutrition & Dietetics

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

Samuel T. Henderson et al.

NUTRITION & METABOLISM (2009)

添加到收藏夹

Article Neurosciences

A functional genomic fingerprint of chronic stress in humans:: Blunted glucocorticoid and increased NF-κB signaling

Gregory E. Miller et al.

BIOLOGICAL PSYCHIATRY (2008)

添加到收藏夹

Review Clinical Neurology

Anticonvulsant mechanisms of the ketogenic diet

Kristopher J. Bough et al.

EPILEPSIA (2007)

添加到收藏夹

Article Psychiatry

Thalamic and prefrontal FDG uptake in never medicated patients with schizophrenia

DS Lehrer et al.

AMERICAN JOURNAL OF PSYCHIATRY (2005)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease - FDG-PET studies in MCI and AD

L Mosconi

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2005)

添加到收藏夹

Article Geriatrics & Gerontology

Effects of β-hydroxybutyrate on cognition in memory-impaired adults

MA Reger et al.

NEUROBIOLOGY OF AGING (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Chronic exposure to β-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes

A Tardif et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2001)

添加到收藏夹

Refueling the post COVID-19 brain: potential role of ketogenic medium chain triglyceride supplementation: an hypothesis

相关参考文献

导出引文

分享论文