☆ 4.6 Article

Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Letter Oncology

Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis

Yizhao Xie et al.

Summary: In this study, a co-culture system of mammary adipocytes and breast cancer cells was established, showing that adipocytes can protect triple-negative breast cancer cells from ferroptosis. Lipidomics analysis revealed that oleic acid secreted from adipocytes inhibits lipid peroxidation and ferroptosis of breast cancer cells through ACSL3.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

添加到收藏夹

Article Cell Biology

Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin-proteasome pathway

Cunte Chen et al.

Summary: This study found that disulfiram (DSF) promotes apoptosis and inhibits proliferation of malignant T-cell cell lines and primary T-ALL cells through targeting the NPL4-mediated ubiquitin-proteasome pathway, offering a potential therapeutic option for T-cell malignancies.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

添加到收藏夹

Review Oncology

The biology of YAP in programmed cell death

Yifan Cheng et al.

Summary: YAP plays a critical role in regulating tumor progression and is closely related to programmed cell death (PCD). YAP activity can be regulated by kinase cascade pathways and other proteins. It has been found that YAP can affect multiple forms of PCD and act as a bridge between different forms of PCD in tumor development.

BIOMARKER RESEARCH (2022)

添加到收藏夹

Review Oncology

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

Xuhui Tong et al.

Summary: This article discusses the molecular processes and effects of necroptosis, pyroptosis, ferroptosis, and cuproptosis on tumor cell proliferation and cancer metastasis, as well as the complex effects of these novel types of tumor cell death on the tumor microenvironment and regulated death of other cells in the microenvironment.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

添加到收藏夹

Article Cell Biology

BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia

Mengjun Zhong et al.

Summary: The BET inhibitor JQ1 was found to inhibit the expression of PD-1 in T cells and enhance anti-leukemia immunity. JQ1 also suppressed the growth of AML cells and prolonged survival in mouse models.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Review Oncology

Targeting metabolic reprogramming in chronic lymphocytic leukemia

Yu Nie et al.

Summary: Metabolic reprogramming plays a vital role in the initiation and progression of chronic lymphocytic leukemia (CLL). This review summarizes the critical metabolic processes in CLL and discusses the regulation of metabolism by cells in the microenvironment and oncogenes/tumor suppressor regulators. Targeting metabolic enzymes or signal pathways may impede the progression of CLL.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2022)

添加到收藏夹

Article Cell Biology

Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2

Yuying Han et al.

Summary: Ferroptosis, a regulated cell death induced by iron-dependent lipid peroxidation, is important in tumor development and drug resistance. In this study, we found that LINC00239 is significantly overexpressed in colorectal cancer (CRC) tissues and its high expression predicts poorer survival and prognosis in CRC patients. We also demonstrated that LINC00239 inhibits ferroptosis, decreasing the anti-tumor activity of certain drugs. Importantly, LINC00239 interacts with Keap1 to regulate ferroptosis, suggesting a potential therapeutic strategy for CRC patients with low LINC00239 expression.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Letter Oncology

CD7-directed CAR T-cell therapy: a potential immunotherapy strategy for relapsed/refractory acute myeloid leukemia

Xuanqi Cao et al.

Summary: CD7 CAR T-cell therapy might be a potential approach for relapsed/refractory AML patients with CD7 expression, leading to leukemia-free state.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2022)

添加到收藏夹

Review Hematology

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis

Dingrui Nie et al.

Summary: Regulated cell death (RCD) is crucial for maintaining cell homeostasis and preventing diseases. In addition to classical apoptosis, several new types of nonapoptotic RCD, including NETosis, pyroptosis, ferroptosis, and cuproptosis, have been discovered and are increasingly recognized for their roles in cancer and inflammation. Disulfiram (DSF), a long-used anti-alcoholic drug, has been found to have potent anti-inflammatory and anti-cancer effects by regulating these new forms of RCD. In this article, we summarize the mechanisms and discuss the potential application of DSF in the treatment of cancers and inflammatory diseases.

BLOOD SCIENCE (2022)

添加到收藏夹

Review Oncology

Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

Yiyi Yao et al.

Summary: Despite advances in chemotherapy and targeted therapies, AML's survival rates are still poor due to chemotherapy resistance and high relapse rates caused by leukemia stem cells. The interaction between hematopoietic cells and the bone marrow microenvironment plays a key role in AML pathogenesis and chemotherapy resistance. Targeting this interaction could be a potential therapeutic strategy to eradicate LSCs and improve AML outcomes.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Yahui Ding et al.

Summary: This study identified a novel approach to treat TNBC by inducing ferroptosis through ubiquitination of GPX4 with the compound DMOCPTL, and revealed the role of GPX4 in regulating mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Furthermore, the prodrug Compound 13 showed promising anti-tumor effects in vivo with no apparent toxicity, suggesting its potential as a lead compound for developing effective anti-TNBC drugs.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Cell Biology

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

Faisal Thayyullathil et al.

Summary: This study reveals a novel role of ASM in promoting ferroptosis through activation and ceramide generation, which are necessary for ROS and LPO induced by Era. NADPH oxidase-derived ROS regulates ASM-initiated redox signaling in a positive feedback manner, while ASM-mediated activation of autophagy plays a crucial role in GPX4 degradation and subsequent ferroptosis. Moreover, genetic activation of ASM increases ferroptosis in cancer cells induced by various FINs, suggesting ASM could be a potential target for improving pathological conditions related to ferroptosis.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Cell Biology

Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells

Haiyang Zhang et al.

Summary: Cancer stem cells are influenced by ferroptosis, a form of cell death involving iron ions and regulated by intracellular signals. The role of ferroptosis in tumor stem cells is crucial for understanding mechanisms of recurrence and drug resistance in cancers.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Cell Biology

Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells

Chen Wang et al.

Summary: The study showed that Cdc25A regulates ferroptosis in cervical cancer cells by modulating the levels of PKM2 and ErbB2, affecting the response of cervical cancer cells to sorafenib treatment.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Cell Biology

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer

Jiawen Yang et al.

Summary: This study demonstrates that cetuximab enhances the cytotoxic effect of RSL3 on KRAS mutant CRC cells by regulating the p38/Nrf2/HO-1 axis to promote ferroptosis. These findings suggest a potential strategy to overcome drug resistance in KRAS mutant colorectal cancer.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Cell Biology

Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11

Hui Dong et al.

Summary: Nrf2 negatively regulates ferroptosis by modulating TERT and SLC7A11 levels, providing potential therapeutic targets for IIR-ALI.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Letter Oncology

Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia

Kehan Li et al.

Summary: The study identified PTK7 as a potential downstream target of BCL11B in T-ALL. Inhibition of the BCL11B pathway leads to reduced PTK7 expression, which induces growth retardation and apoptosis in T-ALL cells via up-regulation of TRAIL and p27.

BIOMARKER RESEARCH (2021)

添加到收藏夹

Article Oncology

A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990-2017

Mohammad Keykhaei et al.

Summary: This study utilized Global Burden of Disease data from 1990 to 2017 to create a Quality of Care Index (QCI) to evaluate the quality of care for hematologic malignancies in different populations. Globally, while the overall age-standardized incidence rate of HMs increased from 1990 to 2017, the age-standardized DALYs and death rates decreased during the same period. Some countries had higher QCI scores for specific HMs, while others had lower scores.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

Advances in acute myeloid leukemia

Laura F. Newell et al.

Summary: AML, a rare and potentially catastrophic diagnosis, has seen recent advancements in personalized therapy and novel treatment options due to discoveries of molecular drivers of the disease.

BMJ-BRITISH MEDICAL JOURNAL (2021)

添加到收藏夹

Review Oncology

The role of ferroptosis in lung cancer

Sikai Wu et al.

Summary: Lung cancer remains a common and deadly disease despite advancements in medical treatment. Targeting the ferroptotic pathway shows promise as a potential strategy for lung cancer therapy, as indicated by recent preclinical evidence.

BIOMARKER RESEARCH (2021)

添加到收藏夹

Article Cell Biology

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

Qiujie Wang et al.

Summary: The study revealed that GSTZ1 enhances sorafenib-induced ferroptosis by inhibiting the NRF2/GPX4 axis in HCC cells, and the combination therapy of sorafenib and GPX4 inhibitor RSL3 may be a promising strategy in HCC treatment.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Letter Oncology

NRF2 activation induced by PML-RARα promotes microRNA 125b-1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia

Xibao Yu et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines

Jiashuo Zheng et al.

Summary: Sorafenib does not induce ferroptosis and only a subset of tumor cell lines experience ferroptosis in response to system x(c)(-) inhibitors. These findings suggest that different tumor cells exhibit varying responses to ferroptosis.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Cell Biology

Differentiation agents increase the potential AraC therapy of AML by reactivating cell death pathways without enhancing ROS generation

Xuening Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Review Oncology

Advances in the Treatment of Acute Myeloid Leukemia: New Drugs and New Challenges

Nicholas J. Short et al.

CANCER DISCOVERY (2020)

添加到收藏夹

Article Oncology

Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer

Ya Cao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Oncology

The global burden and attributable risk factor analysis of acute myeloid leukemia in 195 countries and territories from 1990 to 2017: estimates based on the global burden of disease study 2017

Ming Yi et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Vaishali Aggarwal et al.

BIOMOLECULES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells

Chengwu Zeng et al.

MOLECULAR CANCER (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Kenichi Shimada et al.

NATURE CHEMICAL BIOLOGY (2016)

添加到收藏夹

Article Oncology

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

Francesca Cottini et al.

CANCER DISCOVERY (2015)

添加到收藏夹

Article Oncology

The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

Yan Yu et al.

MOLECULAR & CELLULAR ONCOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

添加到收藏夹

Article Hematology

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance

Stuart A. Rushworth et al.

BLOOD (2012)

添加到收藏夹

Article Oncology

Arsenic trioxide induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion

Bo Ra You et al.

ONCOLOGY REPORTS (2012)

添加到收藏夹

Article Oncology

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

Stuart A. Rushworth et al.

CANCER RESEARCH (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

MG132, a proteasome inhibitor-induced calf pulmonary arterial endothelial cell growth and death, are changed by MAPK inhibitors

Bo Ra You et al.

DRUG AND CHEMICAL TOXICOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. De Nicola et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

被撤回的出版物: Selective killing of cancer cells by a small molecule targeting the stress response to ROS (Retracted article. See vol. 561, pg. 420, 2018)

Lakshmi Raj et al.

NATURE (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

John D. Hayes et al.

TRENDS IN BIOCHEMICAL SCIENCES (2009)

添加到收藏夹

Review Oncology

Acute myeloid leukemia:: Epidemiology and etiology

Barbara Deschler et al.

CANCER (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Glycogen synthase kinase-3β inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2

Maria Salazar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.